UA104422C2 - Похідні індолу та їх застосування для профілактики або лікування діабету або ожиріння - Google Patents

Похідні індолу та їх застосування для профілактики або лікування діабету або ожиріння

Info

Publication number
UA104422C2
UA104422C2 UAA201013332A UAA201013332A UA104422C2 UA 104422 C2 UA104422 C2 UA 104422C2 UA A201013332 A UAA201013332 A UA A201013332A UA A201013332 A UAA201013332 A UA A201013332A UA 104422 C2 UA104422 C2 UA 104422C2
Authority
UA
Ukraine
Prior art keywords
obesity
diabetes
treatment
prevention
indole derivatives
Prior art date
Application number
UAA201013332A
Other languages
English (en)
Russian (ru)
Inventor
Цунео Ясума
Нобуюкі Такакура
Original Assignee
Такеда Фармасьютікал Компані Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Фармасьютікал Компані Лімітед filed Critical Такеда Фармасьютікал Компані Лімітед
Publication of UA104422C2 publication Critical patent/UA104422C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Представлений винахід стосується активатора глюкокінази, який корисний для профілактики або лікування діабету, ожиріння і їм подібних захворювань. Активатор глюкокінази містить сполуку, представлену формулою (І): EMBED MDLDrawOLE.MDLDrawObject.1(I), в якій кожний символ визначений в описі, або її сіль.
UAA201013332A 2008-04-10 2009-04-09 Похідні індолу та їх застосування для профілактики або лікування діабету або ожиріння UA104422C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008102691 2008-04-10
PCT/JP2009/057625 WO2009125873A1 (en) 2008-04-10 2009-04-09 Fused ring compounds and use thereof

Publications (1)

Publication Number Publication Date
UA104422C2 true UA104422C2 (uk) 2014-02-10

Family

ID=40671202

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201013332A UA104422C2 (uk) 2008-04-10 2009-04-09 Похідні індолу та їх застосування для профілактики або лікування діабету або ожиріння

Country Status (35)

Country Link
US (1) US8673942B2 (uk)
EP (1) EP2276760B1 (uk)
JP (1) JP5528348B2 (uk)
KR (1) KR20110002472A (uk)
CN (1) CN102056924B (uk)
AR (1) AR073609A1 (uk)
AU (1) AU2009234666B2 (uk)
BR (1) BRPI0910912A2 (uk)
CA (1) CA2720686A1 (uk)
CO (1) CO6321240A2 (uk)
CR (1) CR11730A (uk)
CY (1) CY1115247T1 (uk)
DK (1) DK2276760T3 (uk)
DO (1) DOP2010000301A (uk)
EA (1) EA019640B1 (uk)
EC (1) ECSP10010602A (uk)
ES (1) ES2476265T3 (uk)
GE (1) GEP20135846B (uk)
HK (1) HK1152932A1 (uk)
HR (1) HRP20140588T1 (uk)
IL (1) IL208463A (uk)
MA (1) MA32283B1 (uk)
ME (1) ME01887B (uk)
MX (1) MX2010011138A (uk)
MY (1) MY152475A (uk)
NZ (1) NZ588562A (uk)
PE (1) PE20100734A1 (uk)
PL (1) PL2276760T3 (uk)
PT (1) PT2276760E (uk)
RS (1) RS53378B (uk)
SI (1) SI2276760T1 (uk)
UA (1) UA104422C2 (uk)
UY (1) UY32131A (uk)
WO (1) WO2009125873A1 (uk)
ZA (1) ZA201007682B (uk)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2371826A4 (en) 2008-12-29 2012-06-27 Takeda Pharmaceutical NEW CONNECTION WITH CONDENSED RINGS AND ITS USE
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9719970B2 (en) 2012-11-30 2017-08-01 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin D metabolites
WO2014099578A1 (en) * 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. Novel glucokinase activator compounds, compositions containing such compounds, and methods of treatment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05505612A (ja) 1991-03-01 1993-08-19 ハー・ルンドベック・アクティーゼルスカブ 高血圧症及び末梢血管疾患の治療法
US6506901B2 (en) 2000-07-17 2003-01-14 Wyeth Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists
WO2003103648A1 (ja) 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 糖尿病治療薬
EP1532980A1 (en) 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
EP1853255A4 (en) 2005-02-22 2009-07-08 Gemin X Pharmaceuticals Canada METHODS FOR TREATING ARTHRITIS USING TRIHETEROCYCLIC COMPOUNDS
EP1873144B1 (en) * 2005-04-20 2014-07-23 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
WO2007037534A1 (ja) * 2005-09-30 2007-04-05 Banyu Pharmaceutical Co., Ltd. ２－へテロアリール置換インドール誘導体
US8410087B2 (en) 2006-10-19 2013-04-02 Takeda Pharmaceutical Company Limited Indole compound
JP5323834B2 (ja) * 2007-08-17 2013-10-23 エルジー・ライフ・サイエンシーズ・リミテッド 細胞壊死阻害剤としてのインドール化合物
EP2220081A4 (en) * 2007-12-20 2011-08-24 Lg Life Sciences Ltd GLUCCOAINEACTIVATORS AND THESE PHARMACEUTICAL COMPOSITIONS CONTAINING ACTIVE SUBSTANCES
KR101098583B1 (ko) * 2008-01-04 2011-12-26 주식회사 엘지생명과학 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체
EP2371826A4 (en) * 2008-12-29 2012-06-27 Takeda Pharmaceutical NEW CONNECTION WITH CONDENSED RINGS AND ITS USE

Also Published As

Publication number Publication date
AU2009234666B2 (en) 2014-02-20
HK1152932A1 (en) 2012-03-16
ZA201007682B (en) 2011-12-28
EA201071180A1 (ru) 2011-04-29
CA2720686A1 (en) 2009-10-15
CN102056924B (zh) 2014-05-21
DOP2010000301A (es) 2010-12-31
CY1115247T1 (el) 2017-01-04
JP5528348B2 (ja) 2014-06-25
ECSP10010602A (es) 2011-03-31
AU2009234666A1 (en) 2009-10-15
AR073609A1 (es) 2010-11-17
EA019640B1 (ru) 2014-05-30
RS53378B (en) 2014-10-31
WO2009125873A1 (en) 2009-10-15
EP2276760B1 (en) 2014-04-09
ES2476265T3 (es) 2014-07-14
US20110098297A1 (en) 2011-04-28
CR11730A (es) 2010-12-08
SI2276760T1 (sl) 2014-05-30
MX2010011138A (es) 2010-11-12
DK2276760T3 (da) 2014-05-26
IL208463A0 (en) 2010-12-30
PT2276760E (pt) 2014-05-28
BRPI0910912A2 (pt) 2015-08-11
ME01887B (me) 2014-12-20
CN102056924A (zh) 2011-05-11
IL208463A (en) 2015-07-30
PL2276760T3 (pl) 2014-09-30
US8673942B2 (en) 2014-03-18
MA32283B1 (fr) 2011-05-02
NZ588562A (en) 2012-07-27
JP2011516403A (ja) 2011-05-26
GEP20135846B (en) 2013-06-10
HRP20140588T1 (hr) 2014-08-01
UY32131A (es) 2010-11-30
KR20110002472A (ko) 2011-01-07
EP2276760A1 (en) 2011-01-26
PE20100734A1 (es) 2010-11-18
MY152475A (en) 2014-10-15
CO6321240A2 (es) 2011-09-20

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