UA101602C2 - Производные бензамидов как антагонисты брадикининовых рецепторов - Google Patents
Производные бензамидов как антагонисты брадикининовых рецепторовInfo
- Publication number
- UA101602C2 UA101602C2 UAA200905339A UAA200905339A UA101602C2 UA 101602 C2 UA101602 C2 UA 101602C2 UA A200905339 A UAA200905339 A UA A200905339A UA A200905339 A UAA200905339 A UA A200905339A UA 101602 C2 UA101602 C2 UA 101602C2
- Authority
- UA
- Ukraine
- Prior art keywords
- antagonists
- benzamide derivatives
- bradykinin receptors
- bradykinin
- receptors
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000010183 Bradykinin receptor Human genes 0.000 title 1
- 108050001736 Bradykinin receptor Proteins 0.000 title 1
- 150000003936 benzamides Chemical class 0.000 title 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- BVFMYNNAEUPDCO-UHFFFAOYSA-N n-(phenylsulfamoyl)benzamide Chemical class C=1C=CC=CC=1C(=O)NS(=O)(=O)NC1=CC=CC=C1 BVFMYNNAEUPDCO-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract
Данное изобретение касается новых производных фенилсульфамоилбензамида формулы (I), где R-Rи Ζ отвечают значениям, указанным в формуле изобретения, и их оптических антиподов или рацематов и/или солей, и/или гидратов, и/или сольватов, которые являются селективными антагонистами брадикинина В1, способа получения таких соединений, фармакологических композиций, которые их содержат, и их применения в лечении и профилактике болевых и воспалительных состояний.
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HU0600808A HUP0600808A3 (en) | 2006-10-27 | 2006-10-27 | New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them |
PCT/HU2007/000102 WO2008068540A1 (en) | 2006-10-27 | 2007-10-27 | New benzamide derivatives as bradykinin antagonists |
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HUP0600809A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
HUP0600810A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
NZ584912A (en) * | 2007-10-27 | 2012-04-27 | Richter Gedeon Nyrt | New non-peptide derivatives as bradykinin b1 antagonists |
EA201170352A1 (ru) * | 2008-08-21 | 2011-08-30 | Рихтер Гедеон Нирт. | Способы лечения расстройств цнс |
CN102159077A (zh) * | 2008-08-21 | 2011-08-17 | 吉瑞工厂 | 用于治疗神经性疼痛的方法 |
NZ594674A (en) * | 2009-02-26 | 2013-12-20 | Boehringer Ingelheim Int | Compounds as bradykinin b1 antagonists |
ES2350077B1 (es) * | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
WO2015175171A1 (en) * | 2014-04-23 | 2015-11-19 | X-Rx Discovery, Inc. | Substituted n-(2-(amino)-2-oxoethyl)benzamide inhibitors of autotaxin and their preparation and use in the treatment of lpa-dependent or lpa-mediated diseases |
KR101676850B1 (ko) | 2015-04-23 | 2016-11-18 | 한일화섬 주식회사 | 내구성이 우수한 스피커용 댐퍼 및 그 제조 방법 |
TW202202495A (zh) | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | 作為gamma-胺基丁酸A受體次單元alpha 5受體調節劑之㖠啶及吡啶并〔3,4-c〕嗒𠯤衍生物 |
HUP2100338A1 (hu) | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
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GB1279843A (en) | 1969-05-23 | 1972-06-28 | Science Union & Cie | Benzamidoethyl-piperazines and process for their preparation |
US5714497A (en) | 1993-02-15 | 1998-02-03 | Sanofi | Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them |
US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
GB9804885D0 (en) | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
GB9913079D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
US6017961A (en) | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
AU2001268607A1 (en) | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Company | Piperidine amides as modulators of chemokine receptor activity |
FR2822827B1 (fr) | 2001-03-28 | 2003-05-16 | Sanofi Synthelabo | Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant |
AU2002346048A1 (en) | 2001-06-07 | 2002-12-16 | Merck And Co., Inc. | Benzodiazepine bradykinin antagonists |
CZ2004233A3 (cs) | 2001-07-24 | 2004-12-15 | Richter Gedeon Vegyészeti Gyár Rt. | Nové amidové sloučeniny karboxylové kyseliny |
US7183281B2 (en) | 2002-05-03 | 2007-02-27 | Elan Pharmaceuticals, Inc. | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists |
US6908921B2 (en) | 2002-12-13 | 2005-06-21 | Merck & Co., Inc. | Quinoxalinone derivatives as bradykinin B1 antagonists |
EP1643960A2 (en) | 2003-07-02 | 2006-04-12 | Merck & Co., Inc. | Arylsulfonamide derivatives |
EP1684759A4 (en) | 2003-11-12 | 2009-06-10 | Merck & Co Inc | INHIBITORS OF 4-PHENYL PIPERIDINE SULFONYL GLYCIN CARRIER |
HU230518B1 (hu) | 2005-12-20 | 2016-10-28 | Richter Gedeon Nyrt. | Bradykinin B1 receptor szelektív antagonista hatással rendelkező új fenatridin származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények |
HUP0600809A3 (en) | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
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NZ584912A (en) | 2007-10-27 | 2012-04-27 | Richter Gedeon Nyrt | New non-peptide derivatives as bradykinin b1 antagonists |
US20110245092A1 (en) | 2008-03-04 | 2011-10-06 | John Bilello | Diagnosing and monitoring depression disorders based on multiple serum biomarker panels |
CN102159077A (zh) | 2008-08-21 | 2011-08-17 | 吉瑞工厂 | 用于治疗神经性疼痛的方法 |
EA201170352A1 (ru) | 2008-08-21 | 2011-08-30 | Рихтер Гедеон Нирт. | Способы лечения расстройств цнс |
WO2011094308A2 (en) | 2010-01-26 | 2011-08-04 | Ridge Diagnostics, Inc. | Multiple biomarker panels to stratify disease severity and monitor treatment of depression |
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