EA201170352A1 - Способы лечения расстройств цнс - Google Patents

Способы лечения расстройств цнс

Info

Publication number
EA201170352A1
EA201170352A1 EA201170352A EA201170352A EA201170352A1 EA 201170352 A1 EA201170352 A1 EA 201170352A1 EA 201170352 A EA201170352 A EA 201170352A EA 201170352 A EA201170352 A EA 201170352A EA 201170352 A1 EA201170352 A1 EA 201170352A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
treatment
cns disorders
oxo
dihydrobenzoxazol
Prior art date
Application number
EA201170352A
Other languages
English (en)
Inventor
Прадип Банерджи
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA201170352A1 publication Critical patent/EA201170352A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение имеет отношение к способам лечения расстройств центральной нервной системы, таких как болезнь Альцгеймера, беспокойство и большое депрессивное расстройство, при помощи введения производных пиперидина, например 2-[4-(4-фторбензил)пиперидин-1-ил]-2-оксо-N-(2-оксо-2,3-дигидробензоксазол-6-ил)ацетамида, и их фармацевтически приемлемых солей.
EA201170352A 2008-08-21 2009-08-21 Способы лечения расстройств цнс EA201170352A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9063008P 2008-08-21 2008-08-21
PCT/US2009/054569 WO2010022304A1 (en) 2008-08-21 2009-08-21 Methods for treating cns disorders

Publications (1)

Publication Number Publication Date
EA201170352A1 true EA201170352A1 (ru) 2011-08-30

Family

ID=41696962

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170352A EA201170352A1 (ru) 2008-08-21 2009-08-21 Способы лечения расстройств цнс

Country Status (8)

Country Link
US (2) US20110190348A1 (ru)
EP (1) EP2331097A4 (ru)
JP (1) JP2012500801A (ru)
CN (1) CN102159210A (ru)
AU (1) AU2009282822A1 (ru)
CA (1) CA2734859A1 (ru)
EA (1) EA201170352A1 (ru)
WO (1) WO2010022304A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP1000312A3 (en) * 2007-10-27 2011-03-28 Richter Gedeon Nyrt New non peptide derivatives as bradykinin bl antagonists
JP2012500800A (ja) * 2008-08-21 2012-01-12 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ 神経因性疼痛の治療法
JP6042968B2 (ja) * 2012-04-20 2016-12-14 ユセベ ファルマ ソシエテ アノニム パーキンソン病の処置方法
JP2015524474A (ja) * 2012-08-06 2015-08-24 エスワン バイオファーマ インコーポレイテッド 治療レジメン
WO2014127256A1 (en) * 2013-02-18 2014-08-21 The Trustees Of Columbia University In The City Of New York Kappa opioid receptor selective compounds
KR20240052765A (ko) * 2021-08-06 2024-04-23 그린 테라퓨틱스 인코포레이티드 라디프로딜의 제형

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714497A (en) * 1993-02-15 1998-02-03 Sanofi Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them
US6451816B1 (en) * 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
GB9804885D0 (en) * 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
US6017961A (en) * 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO
CA2413418A1 (en) * 2000-06-21 2001-12-27 Joseph B. Santella Piperidine amides as modulators of chemokine receptor activity
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
RS50767B (sr) * 2001-07-24 2010-08-31 Richter Gedeon Vegyeszeti Gyar Rt. Piperidinski derivati kao antagonisti nmda receptora
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
WO2005004810A2 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Arylsulfonamide derivatives
CA2544981A1 (en) * 2003-11-12 2005-05-26 Merck & Co., Inc. 4-phenyl piperidine sulfonyl glycine transporter inhibitors
ES2367525T3 (es) * 2005-12-13 2011-11-04 Kyoto University Factor de reprogramación celular.
HU230518B1 (hu) * 2005-12-20 2016-10-28 Richter Gedeon Nyrt. Bradykinin B1 receptor szelektív antagonista hatással rendelkező új fenatridin származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
HUP1000312A3 (en) * 2007-10-27 2011-03-28 Richter Gedeon Nyrt New non peptide derivatives as bradykinin bl antagonists
JP2012500800A (ja) * 2008-08-21 2012-01-12 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ 神経因性疼痛の治療法

Also Published As

Publication number Publication date
EP2331097A4 (en) 2011-12-28
CA2734859A1 (en) 2010-02-25
AU2009282822A1 (en) 2010-02-25
CN102159210A (zh) 2011-08-17
JP2012500801A (ja) 2012-01-12
US20110190348A1 (en) 2011-08-04
EP2331097A1 (en) 2011-06-15
WO2010022304A1 (en) 2010-02-25
US20100048630A1 (en) 2010-02-25

Similar Documents

Publication Publication Date Title
EA201170352A1 (ru) Способы лечения расстройств цнс
EA201200686A1 (ru) Новые терапевтические подходы для лечения болезни альцгеймера
EA201170705A1 (ru) Арилметилбензохиназолиноны в качестве позитивных аллостерических модуляторов рецептора м1
CY1115621T1 (el) Βενζοϊμιδαζολια ως αναστολεις προλυλ υδροξυλασης
NO20090166L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
NO20082481L (no) Nye 2-aminoheterosykluser som er nyttige ved behandling av ABETA-relaterte patologier
NO20090755L (no) Amino-imidazoloner og deres anvendelse som et medikament for behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerering og demens
BRPI0905849A2 (pt) Composto, composição farmacêutica e método
NO20064726L (no) Imidazolforbindelser for behandling av neurodegenerative forstyrrelser
EA201290519A1 (ru) Положительные аллостерические модуляторы рецептора хинолин амида m1
ATE484501T1 (de) Als protein-kinase-inhibitoren nutzbare benzimidazole
EA201390971A1 (ru) ИМИДАЗО[5,1-f][1,2,4]ТРИАЗИНЫ ДЛЯ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ РАССТРОЙСТВ
EA201000331A1 (ru) 1',3-двузамещенные 4-(арил-х-фенил)-1h-пиридин-2-оны
NO20090246L (no) Substituerte isoindoler som bace-inhibitorer og deres anvendelse
CY1113561T1 (el) (2s,3r)-ν-(2-((3-πυριδινυλ)μεθυλ)-1-αζαδικυκλο[2.2.2]οκτ-3-υλ)βενζοφουραν-2-καρβοξαμιδιο, νεες μορφες αλατων και μεθοδοι χρησεως αυτων
EA201000332A1 (ru) 1,3-двузамещенные 4-фенил-1н-пиридин-2-оны
BRPI0811842A2 (pt) Composto, composição farmacêutica, uso de um composto, e, métodos para aumentar a qualidade do sono em um paciente mamífero, para tratar a insônia em um paciente mamífero, e para tratar ou controlar a obesidade em um paciente mamífero
EA201000314A1 (ru) 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2h,1'h-[1,4']бипиридинил-2'-оны
NZ601508A (en) Substituted naphthalenyl-pyrimidine compounds and the use thereof in the treatment of cancer
JO2629B1 (en) Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
EA200801302A1 (ru) Композиции и способы лечения нарушений цнс
EA201990621A1 (ru) Кристаллические формы ингибитора лизилоксидаза-подобного белка 2 и способы получения
ATE396970T1 (de) 2-(1h-indolylsulfanyl)-benzylaminderivate als ssri
MX2022014071A (es) Metodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificacion que comprenden el mismo.
EA200701758A1 (ru) Замещённые арильные производные 1,4-пиразина