TWI878203B - 包含pedf-衍生之短肽之組合物及其用途 - Google Patents

包含pedf-衍生之短肽之組合物及其用途 Download PDF

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Publication number
TWI878203B
TWI878203B TW106133749A TW106133749A TWI878203B TW I878203 B TWI878203 B TW I878203B TW 106133749 A TW106133749 A TW 106133749A TW 106133749 A TW106133749 A TW 106133749A TW I878203 B TWI878203 B TW I878203B
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Taiwan
Prior art keywords
pdsp
peptide
seq
pharmaceutical composition
cells
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TW106133749A
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English (en)
Chinese (zh)
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TW201822785A (zh
Inventor
文機 李
林冠吟
曹友平
何宗權
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全福生物科技股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
TW106133749A 2016-10-07 2017-09-29 包含pedf-衍生之短肽之組合物及其用途 TWI878203B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662405522P 2016-10-07 2016-10-07
US62/405,522 2016-10-07

Publications (2)

Publication Number Publication Date
TW201822785A TW201822785A (zh) 2018-07-01
TWI878203B true TWI878203B (zh) 2025-04-01

Family

ID=61831898

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106133749A TWI878203B (zh) 2016-10-07 2017-09-29 包含pedf-衍生之短肽之組合物及其用途

Country Status (10)

Country Link
US (1) US11760784B2 (cg-RX-API-DMAC7.html)
EP (1) EP3596104A4 (cg-RX-API-DMAC7.html)
JP (2) JP7573967B2 (cg-RX-API-DMAC7.html)
KR (2) KR20230169375A (cg-RX-API-DMAC7.html)
CN (1) CN110312732A (cg-RX-API-DMAC7.html)
AU (2) AU2017340245B2 (cg-RX-API-DMAC7.html)
EA (1) EA037698B1 (cg-RX-API-DMAC7.html)
IL (1) IL265796B2 (cg-RX-API-DMAC7.html)
TW (1) TWI878203B (cg-RX-API-DMAC7.html)
WO (2) WO2018067244A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210221862A1 (en) * 2018-04-08 2021-07-22 Brim Biotechnology, Inc. Application of pedf-derived short peptides in the treatment of osteoarthritis
EP3761959A4 (en) * 2018-04-08 2022-03-02 Brim Biotechnology, Inc. APPLICATION OF PEDF DERIVED SHORT PEPTIDES IN TENDON HEALING
KR20210005696A (ko) * 2018-05-04 2021-01-14 브림 바이오테크놀로지, 인코퍼레이티드 마이봄 샘 재생을 촉진하기 위한 pedf-유래 펩타이드 및 그것의 사용
CN111632128B (zh) * 2019-02-14 2022-07-05 三凡生技研发股份有限公司 短链胜肽组合物在预防或治疗干眼症的应用
TWI759610B (zh) * 2019-06-27 2022-04-01 晶碩光學股份有限公司 具有角膜修護功能的眼用產品
EP4021917A4 (en) * 2019-08-27 2023-05-24 Yeou-Ping Tsao SHORT SYNTHETIC PEPTIDES AND THEIR USES FOR TREATING DEGENERATIVE RETINA DISEASES AND/OR TISSUE DAMAGE
TWI744683B (zh) * 2019-08-27 2021-11-01 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 短合成胜肽及其治療視網膜退化性疾病和/或組織損傷的用途
JP2022550907A (ja) * 2019-10-06 2022-12-05 ブリム バイオテクノロジー インク Ｐｅｄｆ由来短ペプチド（ｐｄｓｐ）を含む組成物及びその使用
CN112206312A (zh) * 2020-11-19 2021-01-12 北京大学第三医院（北京大学第三临床医学院） 一种包含pedf的用于治疗干眼的药物组合物
CN115364199A (zh) * 2021-05-19 2022-11-22 远大医药（中国）有限公司 包含pedf衍生的短肽的组合物及其制备方法和用途
KR20250023387A (ko) * 2022-06-13 2025-02-18 브림 바이오테크놀로지, 인코퍼레이티드 안구 건조증 질환 치료를 위한 pedf 유래 짧은 펩타이드를 포함하는 조성물
TW202400628A (zh) * 2022-06-24 2024-01-01 全福生物科技股份有限公司 用於治療神經營養性角膜炎疾病之包含pedf衍生短肽之組合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508196A1 (en) * 2011-03-23 2012-10-10 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
US20150079094A1 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional Peptide Analogs of PEDF

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451763B1 (en) * 1992-06-04 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Retinal pigmented epithelium derived neurotrophic factor and methods of use
US6797691B1 (en) * 1997-07-23 2004-09-28 Northwestern University Methods and compositions for inhibiting angiogenesis
EP1684692A2 (en) * 2003-10-29 2006-08-02 The Johns Hopkins University Pigment epithelium-derived factor, novel biological activity and methods of use
EP1740218A1 (en) * 2004-03-12 2007-01-10 Genvec, Inc. Materials for treating vascular leakage in the eye
EP1986676A4 (en) * 2006-02-15 2009-11-04 Univ Yale Inc COMPOSITIONS AND METHODS FOR USE OF PEDF (PIGMENT-BASED EPITHELIC DERIVED FACTOR) PEPTIDE FRAGMENTS
EP2716763A3 (en) * 2008-04-29 2014-07-02 Monsanto Technology LLC Genes and uses for plant enhancement
JP2013507373A (ja) * 2009-10-08 2013-03-04 ニューロテック ユーエスエー， インコーポレイテッド 被包された細胞ベースの送達系におけるｐｅｄｆの使用
TWI554521B (zh) * 2011-10-19 2016-10-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 色素上皮衍生因子衍生之多胜肽於治療禿髮和／或毛髮脫色之用途
EP3339317A1 (en) * 2012-08-09 2018-06-27 MacKay Memorial Hospital Use of pedf-derived polypeptides for promoting muscle regeneration
US9815878B2 (en) * 2012-09-19 2017-11-14 Mackay Memorial Hospital Use of PEDF-derived polypeptides for preventing and/or ameliorating skin aging
AU2012390210B2 (en) * 2012-09-20 2017-06-29 Mackay Memorial Hospital Use of PEDF-derived polypeptides for treating osteoarthritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508196A1 (en) * 2011-03-23 2012-10-10 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
US20150079094A1 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional Peptide Analogs of PEDF

Also Published As

Publication number Publication date
JP2022185042A (ja) 2022-12-13
AU2022204557A1 (en) 2022-07-21
WO2018067244A1 (en) 2018-04-12
EP3596104A4 (en) 2021-02-17
TW201822785A (zh) 2018-07-01
AU2017340245A1 (en) 2019-05-23
KR20230169375A (ko) 2023-12-15
EP3596104A1 (en) 2020-01-22
WO2018067217A2 (en) 2018-04-12
CN110312732A (zh) 2019-10-08
IL265796B1 (en) 2024-10-01
IL265796B2 (en) 2025-02-01
EA201990885A1 (ru) 2019-08-30
US11760784B2 (en) 2023-09-19
WO2018067217A3 (en) 2019-05-02
KR20190066030A (ko) 2019-06-12
JP7573967B2 (ja) 2024-10-28
EA037698B1 (ru) 2021-05-12
AU2017340245B2 (en) 2022-07-21
US20190248859A1 (en) 2019-08-15
JP2019533722A (ja) 2019-11-21
IL265796A (en) 2019-06-30

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