TWI846717B - 辨識抗體-藥物結合物之藥物部位的蛋白質 - Google Patents

辨識抗體-藥物結合物之藥物部位的蛋白質 Download PDF

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TWI846717B
TWI846717B TW108126606A TW108126606A TWI846717B TW I846717 B TWI846717 B TW I846717B TW 108126606 A TW108126606 A TW 108126606A TW 108126606 A TW108126606 A TW 108126606A TW I846717 B TWI846717 B TW I846717B
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antibody
amino acid
acid sequence
protein
heavy chain
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TW108126606A
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TW202019973A (zh
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相馬雅子
久我洋
益田剛
河村淳子
石橋裕美
安田哲
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日商第一三共股份有限公司
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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TW108126606A 2018-07-27 2019-07-26 辨識抗體-藥物結合物之藥物部位的蛋白質 TWI846717B (zh)

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JP2018-140912 2018-07-27
JP2018140912 2018-07-27

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TW202019973A TW202019973A (zh) 2020-06-01
TWI846717B true TWI846717B (zh) 2024-07-01

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US (1) US12358999B2 (enExample)
EP (1) EP3831853A4 (enExample)
JP (3) JP7406488B2 (enExample)
KR (1) KR102899298B1 (enExample)
CN (1) CN112533958B (enExample)
AU (1) AU2019311596A1 (enExample)
IL (1) IL280296B2 (enExample)
TW (1) TWI846717B (enExample)
WO (1) WO2020022475A1 (enExample)

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CN113274507B (zh) * 2020-02-20 2025-02-28 亚飞（上海）生物医药科技有限公司 靶向递送和激活的免疫刺激性偶联复合物的制备和用途
US20250276078A1 (en) * 2020-10-12 2025-09-04 Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. Camptothecin Derivative And Ligand-drug Conjugate Thereof
IL309884A (en) * 2021-07-19 2024-03-01 Zeno Man Inc Immunoconjugates and methods
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US20250161473A1 (en) * 2022-01-18 2025-05-22 Gan & Lee Pharmaceuticals Co., Ltd. Exatecan derivative-antibody conjugate and medical use thereof
AU2023274540A1 (en) * 2022-05-24 2024-12-12 Daiichi Sankyo Company, Limited Dosage regimen of an anti-cdh6 antibody-drug conjugate
WO2024175069A1 (zh) 2023-02-23 2024-08-29 一线医药（杭州）有限公司 喜树碱衍生物及其偶联物以及其制备方法和医药用途
TW202444430A (zh) * 2023-04-14 2024-11-16 大陸商山東先聲生物製藥有限公司 抗cdh6抗體藥物偶聯物及其用途
WO2025002310A1 (zh) * 2023-06-29 2025-01-02 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途
WO2025031286A1 (zh) * 2023-08-04 2025-02-13 映恩生物制药（苏州）有限公司 抗体药物偶联物的识别抗体及其应用
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
TW202529818A (zh) * 2024-01-17 2025-08-01 中國商北京泰德製藥股份有限公司 含有噻唑[5,4-b]吡啶結構的抗體偶聯藥物及其用途
WO2025155943A1 (en) * 2024-01-18 2025-07-24 Joinn Biologics Us Inc. Immunoconjugates comprising camptothecin analogs and methods of use thereof
WO2025207828A1 (en) * 2024-03-26 2025-10-02 Fulgent Pharma Llc Nanocomposition comprising modified exatecan and use thereof
WO2025252189A1 (zh) * 2024-06-06 2025-12-11 海思科医药集团股份有限公司 喜树碱类衍生物及其用途

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