JP7406488B2 - 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 - Google Patents

抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 Download PDF

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JP7406488B2
JP7406488B2 JP2020532495A JP2020532495A JP7406488B2 JP 7406488 B2 JP7406488 B2 JP 7406488B2 JP 2020532495 A JP2020532495 A JP 2020532495A JP 2020532495 A JP2020532495 A JP 2020532495A JP 7406488 B2 JP7406488 B2 JP 7406488B2
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amino acid
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JPWO2020022475A5 (enExample
JPWO2020022475A1 (ja
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雅子 相馬
洋 久我
剛 益田
淳子 河村
裕美 石橋
哲 安田
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Daiichi Sankyo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07—ORGANIC CHEMISTRY
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JP2020532495A 2018-07-27 2019-07-26 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 Active JP7406488B2 (ja)

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JP2023212198A JP7502549B2 (ja) 2018-07-27 2023-12-15 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質
JP2024092086A JP7761704B2 (ja) 2018-07-27 2024-06-06 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質

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JP2018140912 2018-07-27
JP2018140912 2018-07-27
PCT/JP2019/029379 WO2020022475A1 (ja) 2018-07-27 2019-07-26 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質

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JP2023212198A Active JP7502549B2 (ja) 2018-07-27 2023-12-15 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質
JP2024092086A Active JP7761704B2 (ja) 2018-07-27 2024-06-06 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質

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JP2024092086A Active JP7761704B2 (ja) 2018-07-27 2024-06-06 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質

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US (1) US12358999B2 (enExample)
EP (1) EP3831853A4 (enExample)
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KR (1) KR102899298B1 (enExample)
CN (1) CN112533958B (enExample)
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018210081A1 (en) * 2017-01-17 2019-08-08 Daiichi Sankyo Company, Limited Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate
AU2020285681A1 (en) * 2019-05-29 2022-01-27 Daiichi Sankyo Company, Limited Dosage of an antibody-drug conjugate
CN113274507B (zh) * 2020-02-20 2025-02-28 亚飞（上海）生物医药科技有限公司 靶向递送和激活的免疫刺激性偶联复合物的制备和用途
US20250276078A1 (en) * 2020-10-12 2025-09-04 Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. Camptothecin Derivative And Ligand-drug Conjugate Thereof
IL309884A (en) * 2021-07-19 2024-03-01 Zeno Man Inc Immunoconjugates and methods
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
US20250161473A1 (en) * 2022-01-18 2025-05-22 Gan & Lee Pharmaceuticals Co., Ltd. Exatecan derivative-antibody conjugate and medical use thereof
AU2023274540A1 (en) * 2022-05-24 2024-12-12 Daiichi Sankyo Company, Limited Dosage regimen of an anti-cdh6 antibody-drug conjugate
WO2024175069A1 (zh) 2023-02-23 2024-08-29 一线医药（杭州）有限公司 喜树碱衍生物及其偶联物以及其制备方法和医药用途
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