TWI842707B - 最佳化抗-tl1a抗體 - Google Patents
最佳化抗-tl1a抗體 Download PDFInfo
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- TWI842707B TWI842707B TW108114566A TW108114566A TWI842707B TW I842707 B TWI842707 B TW I842707B TW 108114566 A TW108114566 A TW 108114566A TW 108114566 A TW108114566 A TW 108114566A TW I842707 B TWI842707 B TW I842707B
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07—ORGANIC CHEMISTRY
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| BR112014007426B1 (pt) | 2011-09-30 | 2023-01-03 | Teva Pharmaceuticals Australia Pty Ltd | Anticorpos contra tl1a e seus usos |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| KR20240128132A (ko) * | 2016-10-26 | 2024-08-23 | 세다르스-신나이 메디칼 센터 | 중화 항-tl1a 단일 클론 항체 |
| KR20250024101A (ko) | 2018-04-25 | 2025-02-18 | 프로메테우스 바이오사이언시즈, 인크. | 최적화된 항tl1a 항체 |
| WO2020112890A1 (en) * | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| KR20220088529A (ko) | 2019-05-14 | 2022-06-27 | 프로메테우스 바이오사이언시즈, 인크. | Tl1a 환자 선택 방법, 시스템 및 장치 |
| TWI871367B (zh) * | 2019-10-24 | 2025-02-01 | 美商普羅米修斯生物科學股份有限公司 | 針對類-tnf配體1a(tl1a)之人類化抗體及其用途 |
| IL292419A (en) * | 2019-10-24 | 2022-06-01 | Prometheus Biosciences Inc | Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof |
| BR112022022020A2 (pt) * | 2020-04-29 | 2023-01-31 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Proteína bifuncional contra pd-1 e tgf-ss |
| CA3187966A1 (en) * | 2020-06-26 | 2021-12-30 | Pfizer Inc. | Methods of treating inflammatory bowel disease with tl1a antibodies |
| MX2023005688A (es) * | 2020-11-13 | 2023-07-18 | Prometheus Biosciences Inc | Metodos, sistemas y equipos para el tratamiento de enfermedades inflamatorias dirigidas al tl1a. |
| EP4294444A4 (en) * | 2021-02-18 | 2025-04-16 | Prometheus Biosciences, Inc. | Compositions containing humanized antibodies against TNF-like ligand 1A (TL1A) and uses thereof |
| JP2025528015A (ja) * | 2022-08-19 | 2025-08-26 | スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド | Ｐｔｋ７結合タンパク質及びその用途 |
| WO2024239006A1 (en) | 2023-05-17 | 2024-11-21 | Genentech, Inc. | Anti-tl1a antibody therapeutic methods |
| CN119306830B (zh) * | 2023-07-11 | 2025-06-20 | 东莞市朋志生物科技有限公司 | 抗皮质醇抗体、检测皮质醇的试剂和试剂盒 |
| WO2025038473A1 (en) | 2023-08-11 | 2025-02-20 | Paragon Therapeutics, Inc. | Tl1a binding antibodies and methods of use |
| US20250109209A1 (en) | 2023-10-03 | 2025-04-03 | Absci Corporation | Tl1a associated antibody compositions and methods of use |
| WO2025137344A1 (en) | 2023-12-20 | 2025-06-26 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rβ) and related methods |
| WO2025140188A1 (zh) * | 2023-12-29 | 2025-07-03 | 成都优洛生物科技有限公司 | 抗tl1a抗体或其抗原结合片段及应用 |
| US12319742B1 (en) | 2024-01-24 | 2025-06-03 | Shattuck Labs, Inc. | Antibodies that bind TNFRSF25 |
| EP4592319A1 (en) | 2024-01-26 | 2025-07-30 | Futuregen Biopharmaceutical (Beijing) Co., Ltd. | Antibodies capable of specifically binding tnf-like ligand 1a and use thereof |
| CN120424214A (zh) * | 2024-02-05 | 2025-08-05 | 三生国健药业（上海）股份有限公司 | 一种抗tl1a抗体及其制备方法和用途 |
| WO2025240922A1 (en) | 2024-05-17 | 2025-11-20 | Genentech, Inc. | Methods for treatment of inflammatory bowel disease with an anti-tl1a antibody |
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