TWI778934B - 利用25-羥維生素d之輔助療法 - Google Patents

利用25-羥維生素d之輔助療法 Download PDF

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Publication number
TWI778934B
TWI778934B TW104125843A TW104125843A TWI778934B TW I778934 B TWI778934 B TW I778934B TW 104125843 A TW104125843 A TW 104125843A TW 104125843 A TW104125843 A TW 104125843A TW I778934 B TWI778934 B TW I778934B
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Taiwan
Prior art keywords
hydroxyvitamin
bone
hypocalcemia
cancer
patient
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TW104125843A
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English (en)
Chinese (zh)
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TW201613607A (en
Inventor
P 馬汀 沛特考維奇
喬爾Z 梅爾尼克
杰A 懷特
薩米爾P 塔巴區
查爾斯W 畢夏普
蘇珊H 皮爾斯
史蒂芬A 史特拉格奈爾
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愛爾蘭商歐科愛爾蘭全球控股股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/0012Galenical forms characterised by the site of application
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    • AHUMAN NECESSITIES
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4875Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
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    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Diabetes (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
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  • Biochemistry (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW104125843A 2014-08-07 2015-08-07 利用25-羥維生素d之輔助療法 TWI778934B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462034604P 2014-08-07 2014-08-07
US62/034,604 2014-08-07

Publications (2)

Publication Number Publication Date
TW201613607A TW201613607A (en) 2016-04-16
TWI778934B true TWI778934B (zh) 2022-10-01

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ID=53783233

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TW104125843A TWI778934B (zh) 2014-08-07 2015-08-07 利用25-羥維生素d之輔助療法
TW110148546A TW202241453A (zh) 2014-08-07 2015-08-07 利用25-羥維生素d之輔助療法

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US (2) US20180085381A1 (enExample)
EP (1) EP3193925A2 (enExample)
JP (5) JP2017523220A (enExample)
KR (2) KR20170047265A (enExample)
CN (2) CN106604733A (enExample)
AU (2) AU2015298858A1 (enExample)
BR (1) BR112017002526A2 (enExample)
CA (1) CA2957240A1 (enExample)
CL (1) CL2017000317A1 (enExample)
CO (2) CO2018004206A2 (enExample)
CR (2) CR20210577A (enExample)
EA (1) EA201790332A1 (enExample)
EC (1) ECSP17014159A (enExample)
IL (1) IL250462A0 (enExample)
MX (1) MX2017001751A (enExample)
MY (1) MY203284A (enExample)
PE (1) PE20170392A1 (enExample)
PH (2) PH12017500228A1 (enExample)
SG (2) SG10201911274TA (enExample)
TW (2) TWI778934B (enExample)
WO (1) WO2016020508A2 (enExample)

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SI1993559T1 (sl) 2006-02-03 2017-01-31 Opko Renal, Llc Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3
DK3357496T3 (da) 2006-06-21 2020-05-11 Opko Ireland Global Holdings Ltd Terapi ved brug af vitamin d-repletteringsmiddel og vitamin d-hormonsubstitutionsmiddel
PT2148684E (pt) 2007-04-25 2013-04-19 Cytochroma Inc Método de tratamento para a insuficiência e deficiência de vitamina d
PT2148661E (pt) 2007-04-25 2013-03-06 Proventiv Therapeutics Llc Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso
US11672809B2 (en) 2010-03-29 2023-06-13 Eirgen Pharma Ltd. Methods and compositions for reducing parathyroid levels
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 d 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
WO2017182237A1 (en) 2016-03-28 2017-10-26 Opko Ireland Global Holdings, Limited Methods of vitamin d treatment
DK3246032T3 (da) * 2016-05-20 2021-10-11 Christoph Karl Farmaceutiske præparater med zoledronsyre, kalcium og d-vitamin, egnede til behandling og/eller profylakse af sygdomme i knoglestofskiftet og af terapibetingede bivirkninger såsom hypokalcæmier
EP3458093A1 (de) * 2016-05-20 2019-03-27 Christoph Karl Pharmazeutische zusammensetzungen mit anti-rankl-antikörpern, kalzium und vitamin d, geeignet zur behandlung und/oder prophylaxe von erkrankungen des knochenstoffwechsels und von therapiebedingten nebenwirkungen wie hypokalzämien
CN108519448B (zh) * 2018-04-04 2021-04-13 北京市心肺血管疾病研究所 25-羟基维生素d在制备大动脉炎患者疾病活动性评判试剂盒中的应用
PE20211489A1 (es) 2018-08-31 2021-08-11 Opko Ireland Global Holdings Ltd Formas de dosificacion pediatricas de vitamina d, metodos de elaboracion y uso
TW202203936A (zh) * 2020-04-06 2022-02-01 愛爾蘭商艾爾根製藥有限公司 啟動內源性抗菌藥物治療sars-cov-2感染
WO2025094144A1 (en) 2023-11-02 2025-05-08 Eirgen Pharma Ltd. Controlling loss of kidney function

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EP2136814A4 (en) * 2007-03-21 2012-05-30 Univ Duke MEDICAL KITS AND FORMULATIONS FOR PREVENTING, TREATING OR REDUCING SECONDARY FRACTURES FROM A PREVIOUS FRACTURE
PT2148661E (pt) * 2007-04-25 2013-03-06 Proventiv Therapeutics Llc Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso
ES3047207T3 (en) * 2007-04-25 2025-12-03 Opko Renal Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
PT2148684E (pt) * 2007-04-25 2013-04-19 Cytochroma Inc Método de tratamento para a insuficiência e deficiência de vitamina d
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US20110039809A1 (en) * 2008-02-13 2011-02-17 Neil Robert Buck Combined use of 25-hydroxy-vitamin d3 and vitamin d3 for improving bone mineral density and for treating osteoporisis
KR20120005228A (ko) * 2010-07-08 2012-01-16 주식회사 네비팜 골다공증 치료용 비스포스폰산 함유 장용 약학조성물 및 그의 제조방법
US20130085121A1 (en) * 2011-09-30 2013-04-04 Jianguo Wang Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d
KR101847947B1 (ko) * 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 d 방출 제형

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