AU2015298858A1 - Adjunctive therapy with 25-hydroxyvitamin D - Google Patents

Adjunctive therapy with 25-hydroxyvitamin D Download PDF

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Publication number
AU2015298858A1
AU2015298858A1 AU2015298858A AU2015298858A AU2015298858A1 AU 2015298858 A1 AU2015298858 A1 AU 2015298858A1 AU 2015298858 A AU2015298858 A AU 2015298858A AU 2015298858 A AU2015298858 A AU 2015298858A AU 2015298858 A1 AU2015298858 A1 AU 2015298858A1
Authority
AU
Australia
Prior art keywords
hydroxyvitamin
patient
agent
composition
hypocalcemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2015298858A
Other languages
English (en)
Inventor
Charles W. Bishop
Joel Z Melnick
Susan H. Peers
P. Martin Petkovich
Stephen A. Strugnell
Samir P. Tabash
Jay A White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Opko Ireland Global Holdings Ltd
Original Assignee
Opko Ireland Global Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53783233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2015298858(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Ireland Global Holdings Ltd filed Critical Opko Ireland Global Holdings Ltd
Publication of AU2015298858A1 publication Critical patent/AU2015298858A1/en
Priority to AU2020267276A priority Critical patent/AU2020267276B2/en
Abandoned legal-status Critical Current

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    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015298858A 2014-08-07 2015-08-06 Adjunctive therapy with 25-hydroxyvitamin D Abandoned AU2015298858A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020267276A AU2020267276B2 (en) 2014-08-07 2020-11-13 Adjunctive therapy with 25-hydroxyvitamin d

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034604P 2014-08-07 2014-08-07
US62/034,604 2014-08-07
PCT/EP2015/068219 WO2016020508A2 (en) 2014-08-07 2015-08-06 Adjunctive therapy with 25-hydroxyvitamin d

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020267276A Division AU2020267276B2 (en) 2014-08-07 2020-11-13 Adjunctive therapy with 25-hydroxyvitamin d

Publications (1)

Publication Number Publication Date
AU2015298858A1 true AU2015298858A1 (en) 2017-03-02

Family

ID=53783233

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015298858A Abandoned AU2015298858A1 (en) 2014-08-07 2015-08-06 Adjunctive therapy with 25-hydroxyvitamin D
AU2020267276A Active AU2020267276B2 (en) 2014-08-07 2020-11-13 Adjunctive therapy with 25-hydroxyvitamin d

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020267276A Active AU2020267276B2 (en) 2014-08-07 2020-11-13 Adjunctive therapy with 25-hydroxyvitamin d

Country Status (21)

Country Link
US (2) US20180085381A1 (enExample)
EP (1) EP3193925A2 (enExample)
JP (5) JP2017523220A (enExample)
KR (2) KR20170047265A (enExample)
CN (2) CN114681468A (enExample)
AU (2) AU2015298858A1 (enExample)
BR (1) BR112017002526A2 (enExample)
CA (1) CA2957240A1 (enExample)
CL (1) CL2017000317A1 (enExample)
CO (2) CO2018004206A2 (enExample)
CR (2) CR20170085A (enExample)
EA (1) EA201790332A1 (enExample)
EC (1) ECSP17014159A (enExample)
IL (1) IL250462A0 (enExample)
MX (1) MX2017001751A (enExample)
MY (1) MY203284A (enExample)
PE (1) PE20170392A1 (enExample)
PH (2) PH12017500228A1 (enExample)
SG (2) SG11201700858RA (enExample)
TW (2) TWI778934B (enExample)
WO (1) WO2016020508A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1993559B1 (en) 2006-02-03 2016-06-22 OPKO Renal, LLC Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
ES2670029T3 (es) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D
CA2683628C (en) 2007-04-25 2018-03-06 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
HRP20231142T3 (hr) 2007-04-25 2024-01-05 Eirgen Pharma Ltd. Kontrolirano oslobađanje 25-hidroksivitamina d
WO2011123476A1 (en) 2010-03-29 2011-10-06 Cytochroma Inc. Methods and compositions for reducing parathyroid levels
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) * 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
CN108883120A (zh) 2016-03-28 2018-11-23 欧普科爱尔兰环球控股有限公司 维生素d治疗方法
US20190290756A1 (en) * 2016-05-20 2019-09-26 Christoph Karl Pharmaceutical compositions with anti-rankl antibodies, calcium and vitamin d
EP3246032B1 (de) * 2016-05-20 2021-08-11 Christoph Karl Pharmazeutische zusammensetzungen mit zoledronsaeure, kalzium und vitamin d, geeignet zur behandlung und/oder prophylaxe von erkrankungen des knochenstoffwechsels und von therapiebedingten nebenwirkungen wie hypokalzaemien
CN108519448B (zh) * 2018-04-04 2021-04-13 北京市心肺血管疾病研究所 25-羟基维生素d在制备大动脉炎患者疾病活动性评判试剂盒中的应用
CN120154576A (zh) 2018-08-31 2025-06-17 欧普科爱尔兰环球控股有限公司 儿童剂型、制造和使用方法
TW202203936A (zh) * 2020-04-06 2022-02-01 愛爾蘭商艾爾根製藥有限公司 啟動內源性抗菌藥物治療ｓａｒｓ－ｃｏｖ－２感染
WO2025094144A1 (en) 2023-11-02 2025-05-08 Eirgen Pharma Ltd. Controlling loss of kidney function

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2845342B2 (ja) * 1990-04-28 1999-01-13 大正製薬株式会社 ビタミンｄ▲下３▼誘導体含有固形製剤組成物
JP2005531532A (ja) * 2002-04-05 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド アレンドロナートおよびビタミンｄ製剤を用いる骨吸収阻害法
EP1499303A4 (en) * 2002-04-10 2007-07-25 Fred H Miller MULTIPHASE MULTI-COMPONENT CAPSULE SYSTEM
TWI336260B (en) * 2002-07-25 2011-01-21 Glaxo Group Ltd Dosage form suitable for retaining drug substance
DE20321698U1 (de) * 2002-12-16 2008-12-24 Teva Pharmaceutical Industries Ltd. Medikament zur Erhöhung der Bioverfügbarkeit von Alendronat oder einem anderen Bisphosphonat durch Verabreichen einer Vordosis eines Vitamin-D-Derivats
EP2136814A4 (en) * 2007-03-21 2012-05-30 Univ Duke MEDICAL KITS AND FORMULATIONS FOR PREVENTING, TREATING OR REDUCING SECONDARY FRACTURES FROM A PREVIOUS FRACTURE
CA2684778C (en) * 2007-04-25 2017-09-05 Cytochroma Inc. Methods and compounds for vitamin d therapy
CA2683628C (en) * 2007-04-25 2018-03-06 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
HRP20231142T3 (hr) * 2007-04-25 2024-01-05 Eirgen Pharma Ltd. Kontrolirano oslobađanje 25-hidroksivitamina d
JP2010525080A (ja) * 2007-04-25 2010-07-22 プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法
KR20100126376A (ko) * 2008-02-13 2010-12-01 디에스엠 아이피 어셋츠 비.브이. 골 무기질 밀도를 개선시키고 골다공증을 치료하기 위한 25-하이드록시-비타민 ｄ3과 비타민 ｄ3의 조합된 용도
KR20120005228A (ko) * 2010-07-08 2012-01-16 주식회사 네비팜 골다공증 치료용 비스포스폰산 함유 장용 약학조성물 및 그의 제조방법
US20130085121A1 (en) * 2011-09-30 2013-04-04 Jianguo Wang Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d
KR101847947B1 (ko) * 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형

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