TWI714522B - Cpmv強化子元件 - Google Patents

Cpmv強化子元件 Download PDF

Info

Publication number
TWI714522B
TWI714522B TW104100482A TW104100482A TWI714522B TW I714522 B TWI714522 B TW I714522B TW 104100482 A TW104100482 A TW 104100482A TW 104100482 A TW104100482 A TW 104100482A TW I714522 B TWI714522 B TW I714522B
Authority
TW
Taiwan
Prior art keywords
sequence
plant
seq
interest
construct
Prior art date
Application number
TW104100482A
Other languages
English (en)
Chinese (zh)
Other versions
TW201610154A (zh
Inventor
皮埃爾-奧利維爾 拉沃伊
馬克－安德烈 德奧斯特
Original Assignee
加拿大商苜蓿股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53523412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI714522(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 加拿大商苜蓿股份有限公司 filed Critical 加拿大商苜蓿股份有限公司
Publication of TW201610154A publication Critical patent/TW201610154A/zh
Application granted granted Critical
Publication of TWI714522B publication Critical patent/TWI714522B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW104100482A 2014-01-10 2015-01-08 Cpmv強化子元件 TWI714522B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461925852P 2014-01-10 2014-01-10
US61/925,852 2014-01-10

Publications (2)

Publication Number Publication Date
TW201610154A TW201610154A (zh) 2016-03-16
TWI714522B true TWI714522B (zh) 2021-01-01

Family

ID=53523412

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104100482A TWI714522B (zh) 2014-01-10 2015-01-08 Cpmv強化子元件

Country Status (12)

Country Link
US (2) US11441150B2 (cg-RX-API-DMAC7.html)
EP (1) EP3092309B1 (cg-RX-API-DMAC7.html)
JP (1) JP6518257B2 (cg-RX-API-DMAC7.html)
CN (1) CN105980561B (cg-RX-API-DMAC7.html)
AU (1) AU2015205805B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016015875A2 (cg-RX-API-DMAC7.html)
CA (1) CA2936350C (cg-RX-API-DMAC7.html)
DK (1) DK3092309T3 (cg-RX-API-DMAC7.html)
ES (1) ES2864081T3 (cg-RX-API-DMAC7.html)
RU (1) RU2699982C2 (cg-RX-API-DMAC7.html)
TW (1) TWI714522B (cg-RX-API-DMAC7.html)
WO (1) WO2015103704A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
DK3092309T3 (da) * 2014-01-10 2021-04-12 Medicago Inc Cpmv-forstærkerelementer
EP3765618A4 (en) 2018-03-14 2022-01-05 Medicago Inc. PLANT EXPRESSION ACTIVATOR
BR112021017899A2 (pt) * 2019-03-14 2021-12-21 Medicago Inc Intensificador de expressão vegetal endógeno

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103282501A (zh) * 2010-11-04 2013-09-04 麦迪卡格公司 植物表达系统

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9414118D0 (en) 1994-07-13 1994-08-31 Axis Genetics Ltd Modified plant viruses as vectors of heterologous peptides
US6042832A (en) 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins
US20010006950A1 (en) 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6489537B1 (en) 1998-08-07 2002-12-03 The Trustees Of The University Of Pennsylvania Phytochelatin synthases and uses therefor
US6287570B1 (en) 1998-11-23 2001-09-11 Patricia L. Foley Vaccine against swine influenza virus
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
MXPA02005559A (es) 1999-12-06 2004-09-10 Univ Illinois Proteinas de tcr de alta afinidad y metodos.
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
US20060277628A1 (en) * 2002-12-27 2006-12-07 Centro De Ingenieria Genetica Y Biotecnologia Artificial promoter for the expression of dna sequences in vegetal cells
US20040268442A1 (en) 2003-05-05 2004-12-30 Dow Agrosciences Llc Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production
NZ543348A (en) 2003-05-05 2008-08-29 Thompson Boyce Plant Res Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
CA2529647C (en) 2003-06-16 2013-08-13 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US8080255B2 (en) 2003-07-11 2011-12-20 Novavax Inc. Functional influenza virus like particles (VLPs)
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
PT2374892T (pt) 2005-04-29 2018-03-29 Univ Cape Town Expressão de proteínas virais em plantas
CN101227920A (zh) 2005-07-19 2008-07-23 陶氏环球技术公司 重组流感疫苗
AU2006304640B2 (en) 2005-10-18 2012-10-11 Novavax, Inc. Functional influenza virus like particles (VLPs)
CA2642054C (en) 2006-02-13 2017-11-21 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
EP2476432B1 (en) 2006-03-07 2015-08-19 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
US7618815B2 (en) 2006-03-08 2009-11-17 University Of Kentucky Research Foundation Viral vectors useful in soybean and methods of use
WO2007135480A1 (en) * 2006-05-22 2007-11-29 Plant Bioscience Limited Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants
US8697088B2 (en) 2007-05-25 2014-04-15 Novavax, Inc. VLPs derived from cells that do not express a viral matrix or core protein
NZ587108A (en) * 2007-11-27 2013-04-26 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
GB0724752D0 (en) * 2007-12-19 2008-01-30 Bari Mazhar A Method for producing a thermoelectric material
GB0800272D0 (en) * 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
KR101956910B1 (ko) * 2008-01-21 2019-03-12 메디카고 인코포레이티드 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ)
JP2012521786A (ja) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
JP5871796B2 (ja) * 2009-06-24 2016-03-01 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
JP2013503640A (ja) 2009-09-04 2013-02-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 植物におけるポリペプチドの発現を増加させるための翻訳エンハンサー要素のスタッキング
RU2579903C2 (ru) 2009-09-22 2016-04-10 Медикаго Инк. Способ получения вирусоподобных частиц растений
SG189236A1 (en) 2010-10-04 2013-05-31 Massachusetts Inst Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
AU2012269684B2 (en) 2011-06-13 2017-06-22 Medicago Inc. Rabies virus like particle production in plants
PL220281B1 (pl) 2011-09-23 2015-09-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
IN2014CN03077A (cg-RX-API-DMAC7.html) 2011-09-30 2015-07-03 Medicago Inc
JP6390846B2 (ja) * 2011-11-11 2018-09-19 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ニコチアナタバカムにおいて生成される血球凝集素を含むインフルエンザウイルス様粒子（ｖｌｐ）
US9555094B2 (en) 2012-07-23 2017-01-31 The Institute Of Biological Resources Isolated nucleic acid for the production of a vaccine against virus
AU2014245779B2 (en) 2013-03-28 2020-02-06 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
DK3092309T3 (da) * 2014-01-10 2021-04-12 Medicago Inc Cpmv-forstærkerelementer
CN106460005B (zh) * 2014-03-27 2020-01-03 莫迪卡戈公司 修饰的cpmv增强子元件

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103282501A (zh) * 2010-11-04 2013-09-04 麦迪卡格公司 植物表达系统

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Sainsbury F et al., "Extremely High-Level and Rapid Transient Protein Production in Plants without the Use of Viral Replication", Plant Physiology, 148(3):1212-1218, 2008/11 *

Also Published As

Publication number Publication date
ES2864081T3 (es) 2021-10-13
DK3092309T3 (da) 2021-04-12
EP3092309A4 (en) 2017-06-28
JP6518257B2 (ja) 2019-05-22
US11884929B2 (en) 2024-01-30
US11441150B2 (en) 2022-09-13
BR112016015875A2 (pt) 2017-09-19
CA2936350C (en) 2023-01-31
RU2699982C2 (ru) 2019-09-11
JP2017501738A (ja) 2017-01-19
AU2015205805B2 (en) 2020-11-12
RU2016132865A3 (cg-RX-API-DMAC7.html) 2018-08-28
CN105980561B (zh) 2020-06-02
CN105980561A (zh) 2016-09-28
WO2015103704A1 (en) 2015-07-16
TW201610154A (zh) 2016-03-16
US20170029832A1 (en) 2017-02-02
CA2936350A1 (en) 2015-07-16
AU2015205805A1 (en) 2016-08-04
EP3092309A1 (en) 2016-11-16
RU2016132865A (ru) 2018-02-14
US20200283784A1 (en) 2020-09-10
EP3092309B1 (en) 2021-02-24

Similar Documents

Publication Publication Date Title
JP6025214B2 (ja) 植物発現系
JP6599354B2 (ja) 改変されたｃｐｍｖエンハンサーエレメント
US11884929B2 (en) CPMV enhancer elements
US20250207144A1 (en) Endogenous plant expression enhancer

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees