CA2936350C - Cpmv enhancer elements - Google Patents

Cpmv enhancer elements Download PDF

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Publication number
CA2936350C
CA2936350C CA2936350A CA2936350A CA2936350C CA 2936350 C CA2936350 C CA 2936350C CA 2936350 A CA2936350 A CA 2936350A CA 2936350 A CA2936350 A CA 2936350A CA 2936350 C CA2936350 C CA 2936350C
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CA
Canada
Prior art keywords
sequence
seq
plant
construct
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2936350A
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English (en)
French (fr)
Other versions
CA2936350A1 (en
Inventor
Pierre-Olivier Lavoie
Marc-Andre D'aoust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicago Inc
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53523412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2936350(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/CA2014/050326 external-priority patent/WO2014153674A1/en
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of CA2936350A1 publication Critical patent/CA2936350A1/en
Application granted granted Critical
Publication of CA2936350C publication Critical patent/CA2936350C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8251Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • C12N7/045Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2936350A 2014-01-10 2015-01-08 Cpmv enhancer elements Active CA2936350C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461925852P 2014-01-10 2014-01-10
US61/925,852 2014-01-10
PCT/CA2014/050326 WO2014153674A1 (en) 2013-03-28 2014-03-28 Influenza virus-like particle production in plants
CAPCT/CA2014/050326 2014-03-28
PCT/CA2015/050009 WO2015103704A1 (en) 2014-01-10 2015-01-08 Cpmv enhancer elements

Publications (2)

Publication Number Publication Date
CA2936350A1 CA2936350A1 (en) 2015-07-16
CA2936350C true CA2936350C (en) 2023-01-31

Family

ID=53523412

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2936350A Active CA2936350C (en) 2014-01-10 2015-01-08 Cpmv enhancer elements

Country Status (12)

Country Link
US (2) US11441150B2 (cg-RX-API-DMAC7.html)
EP (1) EP3092309B1 (cg-RX-API-DMAC7.html)
JP (1) JP6518257B2 (cg-RX-API-DMAC7.html)
CN (1) CN105980561B (cg-RX-API-DMAC7.html)
AU (1) AU2015205805B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016015875A2 (cg-RX-API-DMAC7.html)
CA (1) CA2936350C (cg-RX-API-DMAC7.html)
DK (1) DK3092309T3 (cg-RX-API-DMAC7.html)
ES (1) ES2864081T3 (cg-RX-API-DMAC7.html)
RU (1) RU2699982C2 (cg-RX-API-DMAC7.html)
TW (1) TWI714522B (cg-RX-API-DMAC7.html)
WO (1) WO2015103704A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
DK3092309T3 (da) * 2014-01-10 2021-04-12 Medicago Inc Cpmv-forstærkerelementer
EP3765618A4 (en) 2018-03-14 2022-01-05 Medicago Inc. PLANT EXPRESSION ACTIVATOR
BR112021017899A2 (pt) * 2019-03-14 2021-12-21 Medicago Inc Intensificador de expressão vegetal endógeno

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* Cited by examiner, † Cited by third party
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US20010006950A1 (en) 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6489537B1 (en) 1998-08-07 2002-12-03 The Trustees Of The University Of Pennsylvania Phytochelatin synthases and uses therefor
US6287570B1 (en) 1998-11-23 2001-09-11 Patricia L. Foley Vaccine against swine influenza virus
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
MXPA02005559A (es) 1999-12-06 2004-09-10 Univ Illinois Proteinas de tcr de alta afinidad y metodos.
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
US20060277628A1 (en) * 2002-12-27 2006-12-07 Centro De Ingenieria Genetica Y Biotecnologia Artificial promoter for the expression of dna sequences in vegetal cells
US20040268442A1 (en) 2003-05-05 2004-12-30 Dow Agrosciences Llc Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production
NZ543348A (en) 2003-05-05 2008-08-29 Thompson Boyce Plant Res Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
CA2529647C (en) 2003-06-16 2013-08-13 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US8080255B2 (en) 2003-07-11 2011-12-20 Novavax Inc. Functional influenza virus like particles (VLPs)
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
PT2374892T (pt) 2005-04-29 2018-03-29 Univ Cape Town Expressão de proteínas virais em plantas
CN101227920A (zh) 2005-07-19 2008-07-23 陶氏环球技术公司 重组流感疫苗
AU2006304640B2 (en) 2005-10-18 2012-10-11 Novavax, Inc. Functional influenza virus like particles (VLPs)
CA2642054C (en) 2006-02-13 2017-11-21 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
EP2476432B1 (en) 2006-03-07 2015-08-19 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
US7618815B2 (en) 2006-03-08 2009-11-17 University Of Kentucky Research Foundation Viral vectors useful in soybean and methods of use
WO2007135480A1 (en) * 2006-05-22 2007-11-29 Plant Bioscience Limited Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants
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JP2012521786A (ja) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
JP5871796B2 (ja) * 2009-06-24 2016-03-01 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
JP2013503640A (ja) 2009-09-04 2013-02-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 植物におけるポリペプチドの発現を増加させるための翻訳エンハンサー要素のスタッキング
RU2579903C2 (ru) 2009-09-22 2016-04-10 Медикаго Инк. Способ получения вирусоподобных частиц растений
SG189236A1 (en) 2010-10-04 2013-05-31 Massachusetts Inst Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
CA2815887C (en) * 2010-11-04 2013-12-10 Medicago Inc. Plant expression system
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
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JP6390846B2 (ja) * 2011-11-11 2018-09-19 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ニコチアナタバカムにおいて生成される血球凝集素を含むインフルエンザウイルス様粒子(vlp)
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CN106460005B (zh) * 2014-03-27 2020-01-03 莫迪卡戈公司 修饰的cpmv增强子元件

Also Published As

Publication number Publication date
ES2864081T3 (es) 2021-10-13
DK3092309T3 (da) 2021-04-12
EP3092309A4 (en) 2017-06-28
TWI714522B (zh) 2021-01-01
JP6518257B2 (ja) 2019-05-22
US11884929B2 (en) 2024-01-30
US11441150B2 (en) 2022-09-13
BR112016015875A2 (pt) 2017-09-19
RU2699982C2 (ru) 2019-09-11
JP2017501738A (ja) 2017-01-19
AU2015205805B2 (en) 2020-11-12
RU2016132865A3 (cg-RX-API-DMAC7.html) 2018-08-28
CN105980561B (zh) 2020-06-02
CN105980561A (zh) 2016-09-28
WO2015103704A1 (en) 2015-07-16
TW201610154A (zh) 2016-03-16
US20170029832A1 (en) 2017-02-02
CA2936350A1 (en) 2015-07-16
AU2015205805A1 (en) 2016-08-04
EP3092309A1 (en) 2016-11-16
RU2016132865A (ru) 2018-02-14
US20200283784A1 (en) 2020-09-10
EP3092309B1 (en) 2021-02-24

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Effective date: 20191218

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EEER Examination request

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