TWI711463B - 用於癌症之組合療法 - Google Patents

用於癌症之組合療法 Download PDF

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Publication number
TWI711463B
TWI711463B TW104135474A TW104135474A TWI711463B TW I711463 B TWI711463 B TW I711463B TW 104135474 A TW104135474 A TW 104135474A TW 104135474 A TW104135474 A TW 104135474A TW I711463 B TWI711463 B TW I711463B
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Taiwan
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antibody
csf1r
cancer
dose
heavy chain
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TW104135474A
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Chinese (zh)
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TW201628653A (zh
Inventor
布萊恩 王
茱莉 漢柏利頓
羅柏特 席科斯奇
艾瑪 馬斯特勒
凱文 海斯堤爾
大衛 畢洛維恩
凱薩琳Ｅ 路易斯
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美商戊瑞治療有限公司
美商必治妥美亞史谷比公司
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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TW104135474A 2014-10-29 2015-10-28 用於癌症之組合療法 TWI711463B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462072035P 2014-10-29 2014-10-29
US62/072,035 2014-10-29
US201562157368P 2015-05-05 2015-05-05
US62/157,368 2015-05-05
US201562192025P 2015-07-13 2015-07-13
US62/192,025 2015-07-13

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TW201628653A TW201628653A (zh) 2016-08-16
TWI711463B true TWI711463B (zh) 2020-12-01

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US (5) US9765147B2 (show.php)
EP (2) EP3212670B1 (show.php)
JP (3) JP6920989B2 (show.php)
KR (1) KR102636539B1 (show.php)
CN (1) CN107567336B (show.php)
AU (1) AU2015339306B2 (show.php)
BR (1) BR112017008914A2 (show.php)
CA (1) CA2963147A1 (show.php)
CY (1) CY1123957T1 (show.php)
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PT (1) PT3212670T (show.php)
RS (1) RS61602B1 (show.php)
SG (1) SG11201702723VA (show.php)
SI (1) SI3212670T1 (show.php)
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TW (1) TWI711463B (show.php)
WO (1) WO2016069727A1 (show.php)
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