TWI696633B - 用於T細胞活化之突觸(synTac)多肽類及彼等之用途 - Google Patents

用於T細胞活化之突觸(synTac)多肽類及彼等之用途 Download PDF

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TWI696633B
TWI696633B TW104119612A TW104119612A TWI696633B TW I696633 B TWI696633 B TW I696633B TW 104119612 A TW104119612 A TW 104119612A TW 104119612 A TW104119612 A TW 104119612A TW I696633 B TWI696633 B TW I696633B
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polypeptide
mhc
cases
multimeric
terminus
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TW201613966A (en
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羅納德 西德爾三世
羅多弗 加帕洛
布蘭登 席勒瑞奇
史考特 加佛士
史蒂芬 艾爾莫
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耶奇華大學艾柏特艾因斯坦醫學院
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Transplantation (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW104119612A 2014-06-18 2015-06-17 用於T細胞活化之突觸(synTac)多肽類及彼等之用途 TWI696633B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462013715P 2014-06-18 2014-06-18
US62/013,715 2014-06-18
PCT/US2015/035777 WO2015195531A2 (en) 2014-06-18 2015-06-15 Syntac polypeptides and uses thereof
WOPCT/US15/35777 2015-06-15

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TW201613966A TW201613966A (en) 2016-04-16
TWI696633B true TWI696633B (zh) 2020-06-21

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TW104119612A TWI696633B (zh) 2014-06-18 2015-06-17 用於T細胞活化之突觸(synTac)多肽類及彼等之用途
TW110108178A TWI795740B (zh) 2014-06-18 2015-06-17 用於T細胞活化之突觸(synTac)多肽類及彼等之用途
TW108133859A TWI722576B (zh) 2014-06-18 2015-06-17 用於T細胞活化之突觸(synTac)多肽類及彼等之用途

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TW108133859A TWI722576B (zh) 2014-06-18 2015-06-17 用於T細胞活化之突觸(synTac)多肽類及彼等之用途

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US (5) US20170058015A1 (enExample)
EP (3) EP3480213B1 (enExample)
JP (4) JP6652932B2 (enExample)
KR (1) KR102252119B1 (enExample)
CN (3) CN113248623A (enExample)
AU (3) AU2015277460B2 (enExample)
CA (1) CA2947489A1 (enExample)
DK (2) DK3480213T3 (enExample)
ES (2) ES2767259T3 (enExample)
HU (2) HUE047255T2 (enExample)
IL (3) IL248979B (enExample)
PL (2) PL3480213T3 (enExample)
PT (2) PT3480213T (enExample)
SG (2) SG10202006338UA (enExample)
TW (3) TWI696633B (enExample)
WO (1) WO2015195531A2 (enExample)

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EP3483179B1 (en) 2020-09-16
IL275307A (en) 2020-07-30
EP3480213A1 (en) 2019-05-08
PT3480213T (pt) 2020-02-04
EP3157552B1 (en) 2019-10-23
US20210047384A1 (en) 2021-02-18
CA2947489A1 (en) 2015-12-23
EP3157552A2 (en) 2017-04-26
TW201613966A (en) 2016-04-16
JP6995151B2 (ja) 2022-02-21
PL3480213T3 (pl) 2020-05-18
HUE047255T2 (hu) 2020-04-28
AU2015277460A1 (en) 2016-11-24
CN113248623A (zh) 2021-08-13
ES2770330T3 (es) 2020-07-01
TWI722576B (zh) 2021-03-21
JP6652680B2 (ja) 2020-02-26
JP2017519491A (ja) 2017-07-20
PT3157552T (pt) 2020-01-22
US20170058015A1 (en) 2017-03-02
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CN106456733A (zh) 2017-02-22
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DK3480213T3 (da) 2020-02-17
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DK3157552T3 (da) 2020-01-13
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