TWI690511B - 用於治療疾病之葡萄糖苷基腦醯胺(glucosylceramide)合成酶抑制劑 - Google Patents
用於治療疾病之葡萄糖苷基腦醯胺(glucosylceramide)合成酶抑制劑 Download PDFInfo
- Publication number
- TWI690511B TWI690511B TW103132529A TW103132529A TWI690511B TW I690511 B TWI690511 B TW I690511B TW 103132529 A TW103132529 A TW 103132529A TW 103132529 A TW103132529 A TW 103132529A TW I690511 B TWI690511 B TW I690511B
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- TW
- Taiwan
- Prior art keywords
- chloro
- hydroxy
- pyrrolidin
- cyclopropoxyphenyl
- compound
- Prior art date
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- IWMBLWFHLHFCFP-OAHLLOKOSA-N O[C@H](CCN1CCCC1)c(cc1Cl)ccc1OC1CC1 Chemical compound O[C@H](CCN1CCCC1)c(cc1Cl)ccc1OC1CC1 IWMBLWFHLHFCFP-OAHLLOKOSA-N 0.000 description 1
- PDPGERGWEOJVDC-UHFFFAOYSA-N Oc(c(C(F)(F)F)c1)ccc1Br Chemical compound Oc(c(C(F)(F)F)c1)ccc1Br PDPGERGWEOJVDC-UHFFFAOYSA-N 0.000 description 1
- HFZWRUODUSTPEG-UHFFFAOYSA-N Oc(c(Cl)c1)ccc1Cl Chemical compound Oc(c(Cl)c1)ccc1Cl HFZWRUODUSTPEG-UHFFFAOYSA-N 0.000 description 1
- RHMPLDJJXGPMEX-UHFFFAOYSA-N Oc(cc1)ccc1F Chemical compound Oc(cc1)ccc1F RHMPLDJJXGPMEX-UHFFFAOYSA-N 0.000 description 1
- NWDHTEIVMDYWQJ-UHFFFAOYSA-N Oc1c(C=O)cccc1F Chemical compound Oc1c(C=O)cccc1F NWDHTEIVMDYWQJ-UHFFFAOYSA-N 0.000 description 1
- BAYGVMXZJBFEMB-UHFFFAOYSA-N Oc1ccc(C(F)(F)F)cc1 Chemical compound Oc1ccc(C(F)(F)F)cc1 BAYGVMXZJBFEMB-UHFFFAOYSA-N 0.000 description 1
- YCGDBERFNQCDOM-UHFFFAOYSA-N [NH-]C(CN1CCCC1)C(c(cc1)cc(Cl)c1OC1CC1)O Chemical compound [NH-]C(CN1CCCC1)C(c(cc1)cc(Cl)c1OC1CC1)O YCGDBERFNQCDOM-UHFFFAOYSA-N 0.000 description 1
- RZKKOBGFCAHLCZ-UHFFFAOYSA-N [O-][N+](c1cc(Cl)ccc1Cl)=O Chemical compound [O-][N+](c1cc(Cl)ccc1Cl)=O RZKKOBGFCAHLCZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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| EP3046920B1 (en) | 2021-08-04 |
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| IL244628A0 (en) | 2016-04-21 |
| IL268340A (en) | 2019-09-26 |
| EP3912977A1 (en) | 2021-11-24 |
| WO2015042397A1 (en) | 2015-03-26 |
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