TWI674261B - Nlrp3 調節劑 - Google Patents

Info

Publication number

TWI674261B

TWI674261B TW107105417A TW107105417A TWI674261B TW I674261 B TWI674261 B TW I674261B TW 107105417 A TW107105417 A TW 107105417A TW 107105417 A TW107105417 A TW 107105417A TW I674261 B TWI674261 B TW I674261B

Authority

TW

Taiwan

Prior art keywords

cancer

alkyl

independently selected

compound

ring atoms

Prior art date

2017-02-17

Links

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• 101150061038 NLRP3 gene Proteins 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 188
• 150000003839 salts Chemical class 0.000 claims abstract description 88
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 77
• 201000011510 cancer Diseases 0.000 claims abstract description 56
• 125000000217 alkyl group Chemical group 0.000 claims description 184
• -1 cyclophosphamide Amine Chemical class 0.000 claims description 153
• 229910052757 nitrogen Inorganic materials 0.000 claims description 153
• 125000006413 ring segment Chemical group 0.000 claims description 131
• 125000002947 alkylene group Chemical group 0.000 claims description 99
• 229910052760 oxygen Inorganic materials 0.000 claims description 94
• 229910052717 sulfur Inorganic materials 0.000 claims description 81
• 125000001072 heteroaryl group Chemical group 0.000 claims description 75
• 125000003545 alkoxy group Chemical group 0.000 claims description 40
• 125000003118 aryl group Chemical group 0.000 claims description 39
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 39
• 125000000623 heterocyclic group Chemical group 0.000 claims description 39
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 31
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 29
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 28
• 239000003814 drug Substances 0.000 claims description 28
• 229910052739 hydrogen Inorganic materials 0.000 claims description 23
• 125000001424 substituent group Chemical group 0.000 claims description 21
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 20
• 229910052799 carbon Inorganic materials 0.000 claims description 18
• 125000000392 cycloalkenyl group Chemical group 0.000 claims description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims description 15
• 229910052731 fluorine Inorganic materials 0.000 claims description 13
• 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims description 13
• 206010009944 Colon cancer Diseases 0.000 claims description 12
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 12
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• 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 claims description 12
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 11
• 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 11
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
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• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 5
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• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims description 5
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