CL2019002324A1 - Imidazo-quinolinas sustituidas como moduladores de receptores tipo dominio de oligomerización de fijación a nucleótidos p3 (nlrp3). - Google Patents

Imidazo-quinolinas sustituidas como moduladores de receptores tipo dominio de oligomerización de fijación a nucleótidos p3 (nlrp3).

Info

Publication number
CL2019002324A1
CL2019002324A1 CL2019002324A CL2019002324A CL2019002324A1 CL 2019002324 A1 CL2019002324 A1 CL 2019002324A1 CL 2019002324 A CL2019002324 A CL 2019002324A CL 2019002324 A CL2019002324 A CL 2019002324A CL 2019002324 A1 CL2019002324 A1 CL 2019002324A1
Authority
CL
Chile
Prior art keywords
disease
nlrp3
quinolines
receptor modulators
nucleotide binding
Prior art date
Application number
CL2019002324A
Other languages
English (en)
Spanish (es)
Inventor
Glick Gary
Ghosh Shomir
R Roush William
James Olhava Edward
Danielo'malley
Original Assignee
Innate Tumor Immunity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61283434&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019002324(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innate Tumor Immunity Inc filed Critical Innate Tumor Immunity Inc
Publication of CL2019002324A1 publication Critical patent/CL2019002324A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Optical Communication System (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Transducers For Ultrasonic Waves (AREA)
CL2019002324A 2017-02-17 2019-08-16 Imidazo-quinolinas sustituidas como moduladores de receptores tipo dominio de oligomerización de fijación a nucleótidos p3 (nlrp3). CL2019002324A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762460677P 2017-02-17 2017-02-17
US201762490881P 2017-04-27 2017-04-27
US201762573991P 2017-10-18 2017-10-18

Publications (1)

Publication Number Publication Date
CL2019002324A1 true CL2019002324A1 (es) 2019-11-29

Family

ID=61283434

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019002324A CL2019002324A1 (es) 2017-02-17 2019-08-16 Imidazo-quinolinas sustituidas como moduladores de receptores tipo dominio de oligomerización de fijación a nucleótidos p3 (nlrp3).

Country Status (29)

Country Link
US (4) US10533005B2 (enExample)
EP (2) EP3510034B1 (enExample)
JP (1) JP7003143B6 (enExample)
KR (1) KR102329062B1 (enExample)
CN (1) CN110325534B (enExample)
AU (1) AU2018221076B2 (enExample)
CA (1) CA3053949A1 (enExample)
CL (1) CL2019002324A1 (enExample)
CO (1) CO2019008932A2 (enExample)
CY (1) CY1123305T1 (enExample)
DK (1) DK3510034T3 (enExample)
ES (2) ES2799900T3 (enExample)
HR (1) HRP20201087T1 (enExample)
HU (1) HUE050965T2 (enExample)
IL (1) IL268640B (enExample)
LT (1) LT3510034T (enExample)
ME (1) ME03801B (enExample)
MX (1) MX390065B (enExample)
MY (1) MY194054A (enExample)
PE (1) PE20191552A1 (enExample)
PL (1) PL3510034T3 (enExample)
PT (1) PT3510034T (enExample)
RS (1) RS60548B1 (enExample)
SG (1) SG11201907451XA (enExample)
SI (1) SI3510034T1 (enExample)
SM (1) SMT202000375T1 (enExample)
TW (1) TWI674261B (enExample)
WO (1) WO2018152396A1 (enExample)
ZA (1) ZA201906104B (enExample)

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US11225486B2 (en) 2017-10-18 2022-01-18 Incyte Corporation Tertiary alcohols as PI3K-γ inhibitors
US12173006B2 (en) 2018-09-05 2024-12-24 Incyte Corporation Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor

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IL263616B2 (en) 2016-07-07 2025-01-01 Univ Leland Stanford Junior Antibody-adjuvant conjugates
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
SG11202000248UA (en) 2017-07-14 2020-02-27 Innate Tumor Immunity Inc Nlrp3 modulators
EP3658539B1 (en) 2017-07-24 2024-02-21 Novartis AG Compounds and compositions for treating conditions associated with nlrp activity
JP2020531453A (ja) 2017-08-15 2020-11-05 インフレイゾーム リミテッド Ｎｌｒｐ３阻害剤としてのスルホニルウレアおよびスルホニルチオウレア
WO2019034692A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
JP2021502364A (ja) 2017-11-09 2021-01-28 インフレイゾーム リミテッド 新規なスルホンアミドカルボキサミド化合物
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WO2019209896A1 (en) 2018-04-25 2019-10-31 Innate Tumor Immunity, Inc. Nlrp3 modulators
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EP3837014B1 (en) 2018-08-16 2022-10-19 Innate Tumor Immunity, Inc. Imidazo[4,5-c]quinoline derived nlrp3-modulators
JP7433291B2 (ja) * 2018-08-16 2024-02-19 イネイト・テューマー・イミュニティ・インコーポレイテッド イミダゾ［４，５－ｃ］キノリン誘導体のＮＬＲＰ３モジュレーター
CN111253390B (zh) * 2018-11-30 2023-10-03 四川科伦博泰生物医药股份有限公司 并环化合物、其制备方法及用途
EP3911641A1 (en) * 2019-01-14 2021-11-24 Innate Tumor Immunity, Inc. Nlrp3 modulators
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UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
AU2020407871A1 (en) 2019-12-20 2022-06-30 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing toll-like receptor ("TLR") agonist prodrugs useful in the treatment of cancer and methods thereof
KR20220127848A (ko) * 2020-01-10 2022-09-20 인네이트 튜머 이뮤니티, 인코포레이티드 Nlrp3 조정제
KR102409345B1 (ko) * 2020-09-22 2022-06-16 가톨릭대학교 산학협력단 Nlrp3 인플라마좀 억제제 및 이의 용도
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11225486B2 (en) 2017-10-18 2022-01-18 Incyte Corporation Tertiary alcohols as PI3K-γ inhibitors
US11926630B2 (en) 2017-10-18 2024-03-12 Incyte Corporation Tertiary alcohols as PI3K-γ inhibitors
US12173006B2 (en) 2018-09-05 2024-12-24 Incyte Corporation Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor

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Publication number Publication date
JP7003143B2 (ja) 2022-01-20
CN110325534B (zh) 2024-04-05
IL268640A (en) 2019-10-31
US10533005B2 (en) 2020-01-14
ZA201906104B (en) 2021-05-26
SMT202000375T1 (it) 2020-09-10
AU2018221076A1 (en) 2019-10-03
HRP20201087T1 (hr) 2020-10-30
DK3510034T3 (da) 2020-07-27
EP3510034B1 (en) 2020-04-22
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