TWI666019B - α-同型異構體選擇性磷脂醯肌醇3-激酶抑制劑的劑量療法 - Google Patents

α-同型異構體選擇性磷脂醯肌醇3-激酶抑制劑的劑量療法 Download PDF

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TWI666019B
TWI666019B TW103142503A TW103142503A TWI666019B TW I666019 B TWI666019 B TW I666019B TW 103142503 A TW103142503 A TW 103142503A TW 103142503 A TW103142503 A TW 103142503A TW I666019 B TWI666019 B TW I666019B
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compound
pharmaceutically acceptable
acceptable salt
administered
day
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TW103142503A
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TW201609096A (zh
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托瑪索 伊曼紐 滴
克麗絲汀 弗里奇
瑪莉 卡洛琳 爵瑪
克里斯汀 瑪莎瑟斯
克利絲汀 蕾妮 許內爾
阮加那 塔沃拉奇
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諾華公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW103142503A 2013-12-06 2014-12-05 α-同型異構體選擇性磷脂醯肌醇3-激酶抑制劑的劑量療法 TWI666019B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13306679 2013-12-06
??13306679.5 2013-12-06

Publications (2)

Publication Number Publication Date
TW201609096A TW201609096A (zh) 2016-03-16
TWI666019B true TWI666019B (zh) 2019-07-21

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TW103142503A TWI666019B (zh) 2013-12-06 2014-12-05 α-同型異構體選擇性磷脂醯肌醇3-激酶抑制劑的劑量療法

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US (4) US20170000778A1 (cg-RX-API-DMAC7.html)
EP (2) EP3076969B1 (cg-RX-API-DMAC7.html)
JP (1) JP2016539149A (cg-RX-API-DMAC7.html)
KR (1) KR20160095035A (cg-RX-API-DMAC7.html)
CN (1) CN105979947A (cg-RX-API-DMAC7.html)
AU (2) AU2014358773A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016011811A2 (cg-RX-API-DMAC7.html)
CA (1) CA2930359C (cg-RX-API-DMAC7.html)
CL (1) CL2016001361A1 (cg-RX-API-DMAC7.html)
DK (1) DK3076969T3 (cg-RX-API-DMAC7.html)
ES (1) ES2899167T3 (cg-RX-API-DMAC7.html)
HU (1) HUE057092T2 (cg-RX-API-DMAC7.html)
IL (1) IL245709B (cg-RX-API-DMAC7.html)
MX (1) MX378409B (cg-RX-API-DMAC7.html)
PH (1) PH12016501026A1 (cg-RX-API-DMAC7.html)
PL (1) PL3076969T3 (cg-RX-API-DMAC7.html)
PT (1) PT3076969T (cg-RX-API-DMAC7.html)
RU (1) RU2680246C1 (cg-RX-API-DMAC7.html)
SI (1) SI3076969T1 (cg-RX-API-DMAC7.html)
TN (1) TN2016000179A1 (cg-RX-API-DMAC7.html)
TW (1) TWI666019B (cg-RX-API-DMAC7.html)
WO (1) WO2015083101A1 (cg-RX-API-DMAC7.html)

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WO2018060833A1 (en) * 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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Also Published As

Publication number Publication date
CN105979947A (zh) 2016-09-28
US20180078540A1 (en) 2018-03-22
KR20160095035A (ko) 2016-08-10
US10434092B2 (en) 2019-10-08
ES2899167T3 (es) 2022-03-10
AU2014358773A1 (en) 2016-06-02
SI3076969T1 (sl) 2021-12-31
US20200069670A1 (en) 2020-03-05
IL245709B (en) 2021-03-25
BR112016011811A2 (pt) 2017-08-08
MX2016007376A (es) 2017-05-11
PL3076969T3 (pl) 2022-01-17
EP4000619A1 (en) 2022-05-25
TW201609096A (zh) 2016-03-16
IL245709A0 (en) 2016-07-31
CL2016001361A1 (es) 2017-02-10
US20170000778A1 (en) 2017-01-05
EP3076969B1 (en) 2021-09-01
AU2017245292A1 (en) 2017-11-02
US20210196696A1 (en) 2021-07-01
JP2016539149A (ja) 2016-12-15
MX378409B (es) 2025-03-10
HUE057092T2 (hu) 2022-04-28
RU2680246C1 (ru) 2019-02-19
DK3076969T3 (da) 2021-11-22
PH12016501026A1 (en) 2016-07-04
EP3076969A1 (en) 2016-10-12
TN2016000179A1 (en) 2017-10-06
AU2017245292B2 (en) 2018-09-27
CA2930359C (en) 2022-03-01
CA2930359A1 (en) 2015-06-11
PT3076969T (pt) 2021-11-23
HK1223549A1 (zh) 2017-08-04
WO2015083101A1 (en) 2015-06-11

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