TWI661837B - 包含調酸素衍生物之治療高血脂症的組成物 - Google Patents

包含調酸素衍生物之治療高血脂症的組成物 Download PDF

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Publication number
TWI661837B
TWI661837B TW102126623A TW102126623A TWI661837B TW I661837 B TWI661837 B TW I661837B TW 102126623 A TW102126623 A TW 102126623A TW 102126623 A TW102126623 A TW 102126623A TW I661837 B TWI661837 B TW I661837B
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Taiwan
Prior art keywords
derivative
artificial sequence
mod
fatty liver
res
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TW102126623A
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Chinese (zh)
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TW201416087A (zh
Inventor
鄭聖燁
Sung Youb Jung
金鎭善
Jin-Sun Kim
張明賢
Myung Hyun Jang
李相賢
Sang Hyun Lee
崔仁榮
In Young Choi
權世昌
Se Chang Kwon
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南韓商韓美藥品股份有限公司
Hanmi Pharm. Co., Ltd.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
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  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
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  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
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TW102126623A 2012-07-25 2013-07-25 包含調酸素衍生物之治療高血脂症的組成物 TWI661837B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020120081475A KR101968344B1 (ko) 2012-07-25 2012-07-25 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
??10-2012-0081475 2012-07-25

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TW201416087A TW201416087A (zh) 2014-05-01
TWI661837B true TWI661837B (zh) 2019-06-11

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TW102126623A TWI661837B (zh) 2012-07-25 2013-07-25 包含調酸素衍生物之治療高血脂症的組成物
TW106127084A TWI708614B (zh) 2012-07-25 2013-07-25 包含調酸素衍生物之治療高血脂症的組成物
TW109133876A TWI780493B (zh) 2012-07-25 2013-07-25 包含調酸素衍生物之治療高血脂症的組成物

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TW106127084A TWI708614B (zh) 2012-07-25 2013-07-25 包含調酸素衍生物之治療高血脂症的組成物
TW109133876A TWI780493B (zh) 2012-07-25 2013-07-25 包含調酸素衍生物之治療高血脂症的組成物

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US (3) US20150182593A1 (enExample)
EP (3) EP2884994B1 (enExample)
JP (4) JP2015524427A (enExample)
KR (1) KR101968344B1 (enExample)
CN (2) CN104507492B (enExample)
AR (1) AR091903A1 (enExample)
AU (2) AU2013293714B2 (enExample)
BR (2) BR122022025353B1 (enExample)
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CL (4) CL2015000177A1 (enExample)
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ES (2) ES2942187T3 (enExample)
IL (2) IL236913B (enExample)
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NZ (2) NZ731657A (enExample)
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PH (2) PH12015500158B1 (enExample)
RU (2) RU2768853C1 (enExample)
SG (2) SG11201500519UA (enExample)
TW (3) TWI661837B (enExample)
UA (2) UA118177C2 (enExample)
WO (1) WO2014017843A1 (enExample)
ZA (2) ZA201501238B (enExample)

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RU2739209C2 (ru) 2011-06-10 2020-12-21 Ханми Сайенс Ко., Лтд. Новые производные оксинтомодулина и содержащая их фармацевтическая композиция для лечения ожирения
SI2721062T1 (sl) 2011-06-17 2019-03-29 Hanmi Science Co., Ltd. Konjugat, obsegajoč oksintomodulinski in imunoglobinski fragment, in uporaba le-tega
KR20130049671A (ko) 2011-11-04 2013-05-14 한미사이언스 주식회사 생리활성 폴리펩타이드 결합체 제조 방법
AR090281A1 (es) 2012-03-08 2014-10-29 Hanmi Science Co Ltd Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo
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CL2015000177A1 (es) 2015-05-04
MY171493A (en) 2019-10-15
US10493132B2 (en) 2019-12-03
CL2017002432A1 (es) 2018-04-02
JP6903086B2 (ja) 2021-07-14
UA128812C2 (uk) 2024-10-30
US20150182593A1 (en) 2015-07-02
TW202106338A (zh) 2021-02-16
AU2018203729A1 (en) 2018-06-21
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MX360024B (es) 2018-10-18
PH12015500158A1 (en) 2015-03-16
RU2015104492A (ru) 2016-09-10
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ZA201905331B (en) 2020-05-27
CN107854691A (zh) 2018-03-30
TWI708614B (zh) 2020-11-01
TWI780493B (zh) 2022-10-11
BR122022025353B1 (pt) 2023-11-21
KR101968344B1 (ko) 2019-04-12
MY187988A (en) 2021-11-06
IL274106B2 (en) 2023-08-01
JP2019108394A (ja) 2019-07-04
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EP2884994B1 (en) 2023-01-18
RU2768853C1 (ru) 2022-03-25

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