TWI655179B - 胺基羰基胺基甲酸酯化合物 - Google Patents

胺基羰基胺基甲酸酯化合物 Download PDF

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Publication number
TWI655179B
TWI655179B TW104106005A TW104106005A TWI655179B TW I655179 B TWI655179 B TW I655179B TW 104106005 A TW104106005 A TW 104106005A TW 104106005 A TW104106005 A TW 104106005A TW I655179 B TWI655179 B TW I655179B
Authority
TW
Taiwan
Prior art keywords
aminocarbonyl
amino
propyl
carbamate
compound
Prior art date
Application number
TW104106005A
Other languages
English (en)
Chinese (zh)
Other versions
TW201623224A (zh
Inventor
康永順
Young-Soon Kang
鄭鎭龍
Jin-Yong Chung
孟哲永
Cheol-Young Maeng
李翰柱
Han-Ju Yi
李基好
Ki-Ho Lee
許晙
Joon Heo
蔡銀熙
Eun-Hee Chae
申惟軫
Yu-Jin Shin
Original Assignee
南韓商愛思開生物製藥股份有限公司
Sk Biopharmaceuticals Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南韓商愛思開生物製藥股份有限公司, Sk Biopharmaceuticals Co., Ltd. filed Critical 南韓商愛思開生物製藥股份有限公司
Publication of TW201623224A publication Critical patent/TW201623224A/zh
Application granted granted Critical
Publication of TWI655179B publication Critical patent/TWI655179B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/58—Y being a hetero atom
    • C07C275/60—Y being an oxygen atom, e.g. allophanic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW104106005A 2014-02-28 2015-02-25 胺基羰基胺基甲酸酯化合物 TWI655179B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461946142P 2014-02-28 2014-02-28
US61/946,142 2014-02-28

Publications (2)

Publication Number Publication Date
TW201623224A TW201623224A (zh) 2016-07-01
TWI655179B true TWI655179B (zh) 2019-04-01

Family

ID=54006446

Family Applications (2)

Application Number Title Priority Date Filing Date
TW104106005A TWI655179B (zh) 2014-02-28 2015-02-25 胺基羰基胺基甲酸酯化合物
TW108106172A TWI698415B (zh) 2014-02-28 2015-02-25 胺基羰基胺基甲酸酯化合物

Family Applications After (1)

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TW108106172A TWI698415B (zh) 2014-02-28 2015-02-25 胺基羰基胺基甲酸酯化合物

Country Status (15)

Country Link
US (4) US9403761B2 (enExample)
EP (2) EP3587394B1 (enExample)
JP (2) JP6452731B2 (enExample)
KR (2) KR102487051B1 (enExample)
CN (2) CN109627186B (enExample)
AR (1) AR099581A1 (enExample)
AU (2) AU2015223579B2 (enExample)
CA (1) CA2939835C (enExample)
CL (1) CL2016002165A1 (enExample)
ES (2) ES2968840T3 (enExample)
MX (2) MX2016010973A (enExample)
PL (1) PL3110792T3 (enExample)
RU (1) RU2688673C2 (enExample)
TW (2) TWI655179B (enExample)
WO (1) WO2015130121A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10888542B2 (en) 2014-02-28 2021-01-12 Sk Biopharmaceuticals Co., Ltd. Aminocarbonylcarbamate compounds
TWI655179B (zh) * 2014-02-28 2019-04-01 南韓商愛思開生物製藥股份有限公司 胺基羰基胺基甲酸酯化合物
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
CN120574152A (zh) 2016-09-06 2025-09-02 爱尔兰贾兹制药有限公司 (r)-2-氨基-3-苯丙基氨基甲酸酯盐酸盐的溶剂化物形式的晶体、其制备方法、组合物及用途
MY202185A (en) * 2016-10-06 2024-04-15 Jazz Pharmaceuticals Ireland Ltd Carbamoyl phenylalaninol compounds and uses therof
EP3630072A4 (en) 2017-06-02 2021-03-10 Jazz Pharmaceuticals Ireland Limited METHODS AND COMPOSITIONS FOR TREATMENT OF EXCESSIVE Drowsiness
CN111153863A (zh) * 2019-12-13 2020-05-15 浙江工业大学 一种合成动物用抗球虫药物妥曲珠利的方法
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function
KR102390194B1 (ko) 2020-08-03 2022-04-25 셀라이온바이오메드 주식회사 페닐알킬 카바메이트 화합물을 포함하는 Kca3.1채널 매개질환 치료용 조성물

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0430201A2 (en) * 1989-11-30 1991-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
CN102762201A (zh) * 2009-11-06 2012-10-31 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法

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WO1994010158A1 (fr) * 1992-10-28 1994-05-11 Toyama Chemical Co., Ltd. Nouveaux derives de 1,2-benzisoxazole ou sel dudit derive, et agent de protection cerebrale contenant ce derive
KR100197892B1 (ko) 1994-09-09 1999-06-15 남창우 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법
KR0173862B1 (ko) * 1995-02-11 1999-04-01 조규향 O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
US5756817C1 (en) 1995-02-11 2001-04-17 Sk Corp O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same
KR0173863B1 (ko) 1995-04-10 1999-04-01 조규향 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
EP1636188A1 (en) * 2003-06-12 2006-03-22 Novo Nordisk A/S Para-substituted phenyl carbamates as inhibitors of hormone sensitive lipase
US20050080268A1 (en) 2003-10-08 2005-04-14 Yong-Moon Choi Process of preparing O-carbamoyl compounds in the presence of active amine group
JP4676961B2 (ja) * 2003-10-21 2011-04-27 コルシド・ファーマシューティカルズ・インコーポレイテッド コリンエステラーゼを阻害し、薬理活性物質を放出するカルバモイルエステル類
KR20070083826A (ko) 2004-10-28 2007-08-24 에스케이 주식회사 우울증을 위한 부가 요법
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AU2006254899B2 (en) * 2005-06-08 2011-11-24 Sk Biopharmaceuticals Co., Ltd. Treatment of sleep-wake disorders
DE602006012670D1 (de) 2005-06-22 2010-04-15 Sk Holdings Co Ltd Behandlung der sexuellen dysfunktion
US7531572B2 (en) * 2006-07-28 2009-05-12 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
CN101631770A (zh) * 2007-02-02 2010-01-20 科露西德医药品公司 抑制胆碱酯酶的化合物
RU2567801C2 (ru) 2009-06-22 2015-11-10 Ск Биофармасъютиклс Ко., Лтд. Способы лечения и профилактики усталости
US8232315B2 (en) * 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
WO2011055944A2 (en) 2009-11-06 2011-05-12 Sk Holdings Co., Ltd. Methods for treating fibromyalgia syndrome
US8623913B2 (en) * 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
PL3021838T3 (pl) * 2013-07-18 2021-03-08 Jazz Pharmaceuticals Ireland Limited Leczenie otyłości
TWI655179B (zh) 2014-02-28 2019-04-01 南韓商愛思開生物製藥股份有限公司 胺基羰基胺基甲酸酯化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0430201A2 (en) * 1989-11-30 1991-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
CN102762201A (zh) * 2009-11-06 2012-10-31 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法

Also Published As

Publication number Publication date
ES2759312T3 (es) 2020-05-08
RU2016136193A (ru) 2018-03-30
TW201920086A (zh) 2019-06-01
CN109627186B (zh) 2021-10-29
JP2017512211A (ja) 2017-05-18
AU2019236666B2 (en) 2021-03-25
US20160303067A1 (en) 2016-10-20
TWI698415B (zh) 2020-07-11
EP3110792A1 (en) 2017-01-04
CA2939835A1 (en) 2015-09-03
RU2019113158A (ru) 2019-06-25
PL3110792T3 (pl) 2020-02-28
EP3110792A4 (en) 2017-09-27
KR20210124520A (ko) 2021-10-14
JP6595078B2 (ja) 2019-10-23
CL2016002165A1 (es) 2017-06-09
CN109627186A (zh) 2019-04-16
EP3110792B1 (en) 2019-09-04
US20190247356A1 (en) 2019-08-15
CN106458866B (zh) 2018-12-07
KR102309903B1 (ko) 2021-10-06
AU2019236666A1 (en) 2019-10-17
ES2968840T3 (es) 2024-05-14
EP3587394A1 (en) 2020-01-01
RU2688673C2 (ru) 2019-05-22
CN106458866A (zh) 2017-02-22
KR102487051B1 (ko) 2023-01-09
US10485781B2 (en) 2019-11-26
MX2020003020A (es) 2021-11-11
TW201623224A (zh) 2016-07-01
AR099581A1 (es) 2016-08-03
AU2015223579B2 (en) 2019-06-27
KR20160126988A (ko) 2016-11-02
US20180085337A1 (en) 2018-03-29
US9833432B2 (en) 2017-12-05
JP2019059764A (ja) 2019-04-18
US10314808B2 (en) 2019-06-11
RU2016136193A3 (enExample) 2018-10-29
US9403761B2 (en) 2016-08-02
WO2015130121A1 (en) 2015-09-03
CA2939835C (en) 2022-11-01
EP3587394B1 (en) 2023-11-01
MX387796B (es) 2025-03-19
JP6452731B2 (ja) 2019-01-16
MX2016010973A (es) 2016-11-29
US20150246874A1 (en) 2015-09-03
AU2015223579A1 (en) 2016-08-25

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