TWI609860B - 新穎環狀酯肽(Depsipeptide)衍生物及含有其之有害生物防除劑 - Google Patents

新穎環狀酯肽(Depsipeptide)衍生物及含有其之有害生物防除劑 Download PDF

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Publication number
TWI609860B
TWI609860B TW102121044A TW102121044A TWI609860B TW I609860 B TWI609860 B TW I609860B TW 102121044 A TW102121044 A TW 102121044A TW 102121044 A TW102121044 A TW 102121044A TW I609860 B TWI609860 B TW I609860B
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TW
Taiwan
Prior art keywords
represent
same
formula
compound
group
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TW102121044A
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English (en)
Chinese (zh)
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TW201410659A (zh
Inventor
Masaaki Mitomi
Masayo Sakai
Ryo Horikoshi
Yasumichi Onozaki
Satoshi Nakamura
Satoshi Omura
Toshiaki Sunazuka
Tomoyasu Hirose
Kazuro Shiomi
Rokuro Masuma
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Meiji Seika Pharma Co Ltd
The Kitasato Inst
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Publication of TW201410659A publication Critical patent/TW201410659A/zh
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Publication of TWI609860B publication Critical patent/TWI609860B/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW102121044A 2012-06-13 2013-06-13 新穎環狀酯肽(Depsipeptide)衍生物及含有其之有害生物防除劑 TWI609860B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012134304 2012-06-13

Publications (2)

Publication Number Publication Date
TW201410659A TW201410659A (zh) 2014-03-16
TWI609860B true TWI609860B (zh) 2018-01-01

Family

ID=49758298

Family Applications (1)

Application Number Title Priority Date Filing Date
TW102121044A TWI609860B (zh) 2012-06-13 2013-06-13 新穎環狀酯肽(Depsipeptide)衍生物及含有其之有害生物防除劑

Country Status (19)

Country Link
US (2) US20150166608A1 (enExample)
EP (2) EP2862872B1 (enExample)
JP (1) JP6300207B2 (enExample)
KR (1) KR20150037766A (enExample)
CN (1) CN104540845B (enExample)
AU (2) AU2013275223A1 (enExample)
BR (1) BR112014031334A2 (enExample)
CA (1) CA2876387A1 (enExample)
ES (1) ES2702598T3 (enExample)
HU (1) HUE042661T2 (enExample)
IN (1) IN2014DN10617A (enExample)
MX (1) MX2014014838A (enExample)
NZ (1) NZ703217A (enExample)
PH (1) PH12014502752A1 (enExample)
PL (1) PL2862872T3 (enExample)
PT (1) PT2862872T (enExample)
RU (1) RU2015100521A (enExample)
TW (1) TWI609860B (enExample)
WO (1) WO2013187480A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3038640B1 (en) 2013-08-30 2019-01-02 St. Jude Children's Research Hospital Substituted urea depsipeptide analogs as activators of the clpp endopeptidase
WO2015093558A1 (ja) * 2013-12-18 2015-06-25 Meiji Seikaファルマ株式会社 環状デプシペプチド誘導体およびそれを含んでなる有害生物防除剤
EP3265083B1 (en) 2015-03-04 2022-07-06 St. Jude Children's Research Hospital Substituted urea depsipeptide analogs as activators of the clpp endopeptidase
CN107592872A (zh) 2015-05-08 2018-01-16 埃克森美孚化学专利公司 反应器系统及其相关方法
RS62130B1 (sr) * 2015-05-20 2021-08-31 Boehringer Ingelheim Animal Health Usa Inc Antihelmintička depsipeptidna jedinjenja
EP3397638B1 (en) 2015-12-28 2023-08-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
WO2018045313A1 (en) * 2016-09-02 2018-03-08 St. Jude Children's Research Hospital Substituted urea depsipeptide analogs as activators of the clpp endopeptidase
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
EP3480195A1 (en) * 2017-11-07 2019-05-08 Bayer Animal Health GmbH Method for the synthesis of cyclic depsipeptides
PL3676265T3 (pl) * 2017-11-07 2025-12-15 Elanco Animal Health Gmbh Sposób syntezy cyklicznych depsypeptydów

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0685469A1 (en) * 1993-02-19 1995-12-06 Meiji Seika Kaisha Ltd. Pf1022 derivative, cyclic depsipeptide
JP2008247806A (ja) * 2007-03-30 2008-10-16 Gunma Univ Pf1022類の製造法
WO2011069995A1 (en) * 2009-12-11 2011-06-16 Bayer Animal Health Gmbh Novel 24-membered cyclooctadepsipeptides from fungal strains and their use as anthelmintics or endoparasiticides
TW201306746A (zh) * 2010-12-10 2013-02-16 Meiji Seika Pharma Co Ltd 新穎縮酚酸肽pf1442物質及其製造法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO176766C (no) 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
JP3132167B2 (ja) 1991-08-23 2001-02-05 藤沢薬品工業株式会社 デプシペプチド誘導体の製造法
DK0634408T3 (da) 1992-03-17 2002-04-22 Fujisawa Pharmaceutical Co Depsipeptidderivater, fremstilling og anvendelse deraf
JPH05271013A (ja) 1992-03-27 1993-10-19 Meiji Seika Kaisha Ltd 環状デプシペプチド物質を有効成分とする害虫防除剤
DE4317432A1 (de) 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4317457A1 (de) 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
WO1998037088A1 (en) * 1997-02-19 1998-08-27 Meiji Seika Kaisha Ltd. Derivatives of cyclodepsipeptide, pf1022 substance
DE19828043A1 (de) * 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
DE19840320A1 (de) * 1998-09-04 2000-03-09 Bayer Ag Aza-Cyclodepsipeptide
DE19962145A1 (de) * 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel/Depsipeptide
ES2318053T3 (es) * 2002-11-12 2009-05-01 The Kitasato Institute Sustancia antihelmintica fki-1033 y procedimiento para la produccion de la misma.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0685469A1 (en) * 1993-02-19 1995-12-06 Meiji Seika Kaisha Ltd. Pf1022 derivative, cyclic depsipeptide
JP2008247806A (ja) * 2007-03-30 2008-10-16 Gunma Univ Pf1022類の製造法
WO2011069995A1 (en) * 2009-12-11 2011-06-16 Bayer Animal Health Gmbh Novel 24-membered cyclooctadepsipeptides from fungal strains and their use as anthelmintics or endoparasiticides
TW201306746A (zh) * 2010-12-10 2013-02-16 Meiji Seika Pharma Co Ltd 新穎縮酚酸肽pf1442物質及其製造法

Also Published As

Publication number Publication date
PL2862872T3 (pl) 2019-03-29
IN2014DN10617A (enExample) 2015-09-11
BR112014031334A2 (pt) 2017-06-27
EP3441399A1 (en) 2019-02-13
PT2862872T (pt) 2018-12-17
US20150166608A1 (en) 2015-06-18
TW201410659A (zh) 2014-03-16
ES2702598T3 (es) 2019-03-04
KR20150037766A (ko) 2015-04-08
WO2013187480A1 (ja) 2013-12-19
RU2015100521A (ru) 2016-08-10
CA2876387A1 (en) 2013-12-19
CN104540845A (zh) 2015-04-22
HUE042661T2 (hu) 2019-07-29
PH12014502752A1 (en) 2015-02-23
EP2862872A4 (en) 2015-10-28
AU2013275223A1 (en) 2015-01-22
JPWO2013187480A1 (ja) 2016-02-08
JP6300207B2 (ja) 2018-03-28
NZ703217A (en) 2016-11-25
AU2018201101A1 (en) 2018-03-08
US20170215422A1 (en) 2017-08-03
MX2014014838A (es) 2015-02-12
EP2862872B1 (en) 2018-09-19
EP2862872A1 (en) 2015-04-22
CN104540845B (zh) 2018-01-26

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