RU2015100521A - Новые циклические депсипептидные производные и средства для борьбы с вредными организмами, включающие такие производные - Google Patents
Новые циклические депсипептидные производные и средства для борьбы с вредными организмами, включающие такие производные Download PDFInfo
- Publication number
- RU2015100521A RU2015100521A RU2015100521A RU2015100521A RU2015100521A RU 2015100521 A RU2015100521 A RU 2015100521A RU 2015100521 A RU2015100521 A RU 2015100521A RU 2015100521 A RU2015100521 A RU 2015100521A RU 2015100521 A RU2015100521 A RU 2015100521A
- Authority
- RU
- Russia
- Prior art keywords
- same meaning
- carbon atoms
- represent
- same
- different
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 43
- 150000001875 compounds Chemical class 0.000 claims abstract 35
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 32
- 125000000217 alkyl group Chemical group 0.000 claims abstract 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 20
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 12
- 239000000126 substance Substances 0.000 claims abstract 7
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims abstract 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 6
- 244000045947 parasite Species 0.000 claims 5
- 241000607479 Yersinia pestis Species 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- -1 tert-butyloxycarbonyl (Boc) Chemical class 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-134304 | 2012-06-13 | ||
| JP2012134304 | 2012-06-13 | ||
| PCT/JP2013/066360 WO2013187480A1 (ja) | 2012-06-13 | 2013-06-13 | 新規環状デプシペプチド誘導体およびそれを含んでなる有害生物防除剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015100521A true RU2015100521A (ru) | 2016-08-10 |
Family
ID=49758298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015100521A RU2015100521A (ru) | 2012-06-13 | 2013-06-13 | Новые циклические депсипептидные производные и средства для борьбы с вредными организмами, включающие такие производные |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20150166608A1 (enExample) |
| EP (2) | EP2862872B1 (enExample) |
| JP (1) | JP6300207B2 (enExample) |
| KR (1) | KR20150037766A (enExample) |
| CN (1) | CN104540845B (enExample) |
| AU (2) | AU2013275223A1 (enExample) |
| BR (1) | BR112014031334A2 (enExample) |
| CA (1) | CA2876387A1 (enExample) |
| ES (1) | ES2702598T3 (enExample) |
| HU (1) | HUE042661T2 (enExample) |
| IN (1) | IN2014DN10617A (enExample) |
| MX (1) | MX2014014838A (enExample) |
| NZ (1) | NZ703217A (enExample) |
| PH (1) | PH12014502752A1 (enExample) |
| PL (1) | PL2862872T3 (enExample) |
| PT (1) | PT2862872T (enExample) |
| RU (1) | RU2015100521A (enExample) |
| TW (1) | TWI609860B (enExample) |
| WO (1) | WO2013187480A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2817013C1 (ru) * | 2017-11-07 | 2024-04-09 | Байер Энимэл Хельс ГмбХ | Способ синтеза циклических депсипептидов |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3038640B1 (en) | 2013-08-30 | 2019-01-02 | St. Jude Children's Research Hospital | Substituted urea depsipeptide analogs as activators of the clpp endopeptidase |
| WO2015093558A1 (ja) * | 2013-12-18 | 2015-06-25 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 環状デプシペプチド誘導体およびそれを含んでなる有害生物防除剤 |
| EP3265083B1 (en) | 2015-03-04 | 2022-07-06 | St. Jude Children's Research Hospital | Substituted urea depsipeptide analogs as activators of the clpp endopeptidase |
| CN107592872A (zh) | 2015-05-08 | 2018-01-16 | 埃克森美孚化学专利公司 | 反应器系统及其相关方法 |
| RS62130B1 (sr) * | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018045313A1 (en) * | 2016-09-02 | 2018-03-08 | St. Jude Children's Research Hospital | Substituted urea depsipeptide analogs as activators of the clpp endopeptidase |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| EP3480195A1 (en) * | 2017-11-07 | 2019-05-08 | Bayer Animal Health GmbH | Method for the synthesis of cyclic depsipeptides |
| PL3676265T3 (pl) * | 2017-11-07 | 2025-12-15 | Elanco Animal Health Gmbh | Sposób syntezy cyklicznych depsypeptydów |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO176766C (no) | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
| JP3132167B2 (ja) | 1991-08-23 | 2001-02-05 | 藤沢薬品工業株式会社 | デプシペプチド誘導体の製造法 |
| DK0634408T3 (da) | 1992-03-17 | 2002-04-22 | Fujisawa Pharmaceutical Co | Depsipeptidderivater, fremstilling og anvendelse deraf |
| JPH05271013A (ja) | 1992-03-27 | 1993-10-19 | Meiji Seika Kaisha Ltd | 環状デプシペプチド物質を有効成分とする害虫防除剤 |
| CN1073560C (zh) * | 1993-02-19 | 2001-10-24 | 明治制果株式会社 | 环缩酚酸肽pf1022衍生物 |
| DE4317432A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| DE4317457A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| WO1998037088A1 (en) * | 1997-02-19 | 1998-08-27 | Meiji Seika Kaisha Ltd. | Derivatives of cyclodepsipeptide, pf1022 substance |
| DE19828043A1 (de) * | 1998-06-24 | 1999-12-30 | Bayer Ag | Ektoparasitizide Mittel |
| DE19840320A1 (de) * | 1998-09-04 | 2000-03-09 | Bayer Ag | Aza-Cyclodepsipeptide |
| DE19962145A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Ag | Schädlingsbekämpfungsmittel/Depsipeptide |
| ES2318053T3 (es) * | 2002-11-12 | 2009-05-01 | The Kitasato Institute | Sustancia antihelmintica fki-1033 y procedimiento para la produccion de la misma. |
| JP4734656B2 (ja) * | 2007-03-30 | 2011-07-27 | 国立大学法人群馬大学 | Ｐｆ１０２２類の製造法 |
| WO2011069995A1 (en) | 2009-12-11 | 2011-06-16 | Bayer Animal Health Gmbh | Novel 24-membered cyclooctadepsipeptides from fungal strains and their use as anthelmintics or endoparasiticides |
| JP2014037351A (ja) * | 2010-12-10 | 2014-02-27 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 新規デプシペプチドｐｆ１４４２物質およびその製造法 |
-
2013
- 2013-06-13 CA CA 2876387 patent/CA2876387A1/en not_active Abandoned
- 2013-06-13 PL PL13804000T patent/PL2862872T3/pl unknown
- 2013-06-13 CN CN201380031538.2A patent/CN104540845B/zh not_active Expired - Fee Related
- 2013-06-13 RU RU2015100521A patent/RU2015100521A/ru not_active Application Discontinuation
- 2013-06-13 KR KR20147036738A patent/KR20150037766A/ko not_active Ceased
- 2013-06-13 IN IN10617DEN2014 patent/IN2014DN10617A/en unknown
- 2013-06-13 EP EP13804000.1A patent/EP2862872B1/en not_active Not-in-force
- 2013-06-13 EP EP18194117.0A patent/EP3441399A1/en not_active Withdrawn
- 2013-06-13 ES ES13804000T patent/ES2702598T3/es active Active
- 2013-06-13 TW TW102121044A patent/TWI609860B/zh not_active IP Right Cessation
- 2013-06-13 WO PCT/JP2013/066360 patent/WO2013187480A1/ja not_active Ceased
- 2013-06-13 JP JP2014521405A patent/JP6300207B2/ja not_active Expired - Fee Related
- 2013-06-13 MX MX2014014838A patent/MX2014014838A/es unknown
- 2013-06-13 BR BR112014031334A patent/BR112014031334A2/pt not_active Application Discontinuation
- 2013-06-13 HU HUE13804000A patent/HUE042661T2/hu unknown
- 2013-06-13 PT PT13804000T patent/PT2862872T/pt unknown
- 2013-06-13 US US14/406,318 patent/US20150166608A1/en not_active Abandoned
- 2013-06-13 NZ NZ703217A patent/NZ703217A/en not_active IP Right Cessation
- 2013-06-13 AU AU2013275223A patent/AU2013275223A1/en not_active Abandoned
-
2014
- 2014-12-09 PH PH12014502752A patent/PH12014502752A1/en unknown
-
2017
- 2017-04-17 US US15/488,944 patent/US20170215422A1/en not_active Abandoned
-
2018
- 2018-02-15 AU AU2018201101A patent/AU2018201101A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2817013C1 (ru) * | 2017-11-07 | 2024-04-09 | Байер Энимэл Хельс ГмбХ | Способ синтеза циклических депсипептидов |
Also Published As
| Publication number | Publication date |
|---|---|
| PL2862872T3 (pl) | 2019-03-29 |
| IN2014DN10617A (enExample) | 2015-09-11 |
| BR112014031334A2 (pt) | 2017-06-27 |
| EP3441399A1 (en) | 2019-02-13 |
| PT2862872T (pt) | 2018-12-17 |
| US20150166608A1 (en) | 2015-06-18 |
| TW201410659A (zh) | 2014-03-16 |
| ES2702598T3 (es) | 2019-03-04 |
| TWI609860B (zh) | 2018-01-01 |
| KR20150037766A (ko) | 2015-04-08 |
| WO2013187480A1 (ja) | 2013-12-19 |
| CA2876387A1 (en) | 2013-12-19 |
| CN104540845A (zh) | 2015-04-22 |
| HUE042661T2 (hu) | 2019-07-29 |
| PH12014502752A1 (en) | 2015-02-23 |
| EP2862872A4 (en) | 2015-10-28 |
| AU2013275223A1 (en) | 2015-01-22 |
| JPWO2013187480A1 (ja) | 2016-02-08 |
| JP6300207B2 (ja) | 2018-03-28 |
| NZ703217A (en) | 2016-11-25 |
| AU2018201101A1 (en) | 2018-03-08 |
| US20170215422A1 (en) | 2017-08-03 |
| MX2014014838A (es) | 2015-02-12 |
| EP2862872B1 (en) | 2018-09-19 |
| EP2862872A1 (en) | 2015-04-22 |
| CN104540845B (zh) | 2018-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190621 |