TWI608019B - 多黏菌素衍生物 - Google Patents
多黏菌素衍生物 Download PDFInfo
- Publication number
- TWI608019B TWI608019B TW101142961A TW101142961A TWI608019B TW I608019 B TWI608019 B TW I608019B TW 101142961 A TW101142961 A TW 101142961A TW 101142961 A TW101142961 A TW 101142961A TW I608019 B TWI608019 B TW I608019B
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- Taiwan
- Prior art keywords
- group
- polymyxin
- nonapeptide
- compound
- alkyl
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US201161561361P | 2011-11-18 | 2011-11-18 |
Publications (2)
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|---|---|
| TW201326215A TW201326215A (zh) | 2013-07-01 |
| TWI608019B true TWI608019B (zh) | 2017-12-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101142961A TWI608019B (zh) | 2011-11-18 | 2012-11-16 | 多黏菌素衍生物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9234006B2 (enExample) |
| EP (1) | EP2780357A1 (enExample) |
| JP (1) | JP6185920B2 (enExample) |
| KR (1) | KR20140091724A (enExample) |
| CN (1) | CN103946233A (enExample) |
| AU (1) | AU2012338571B2 (enExample) |
| BR (1) | BR112014012016A2 (enExample) |
| CA (1) | CA2855916A1 (enExample) |
| CO (1) | CO7061068A2 (enExample) |
| EA (1) | EA024792B1 (enExample) |
| IL (1) | IL232278A0 (enExample) |
| MX (1) | MX355217B (enExample) |
| SG (1) | SG11201402390PA (enExample) |
| TW (1) | TWI608019B (enExample) |
| WO (1) | WO2013072695A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX355217B (es) | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| HUE059544T2 (hu) * | 2013-05-22 | 2022-11-28 | Spero Therapeutics Inc | Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal |
| KR20160135739A (ko) * | 2014-03-11 | 2016-11-28 | 뉴 파마 라이센스 홀딩스 리미티드 | 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 |
| US10047126B2 (en) | 2014-04-01 | 2018-08-14 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| CN107108699A (zh) * | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| EP3233889B1 (en) * | 2014-12-16 | 2022-07-06 | Shanghai MicuRx Pharmaceutical Co., Ltd. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| US10322187B2 (en) | 2015-08-10 | 2019-06-18 | Lehigh University | Reduced toxicity molecular conjugates of anti-fungal agents |
| JP7367950B2 (ja) | 2015-09-29 | 2023-10-24 | モナッシュ ユニバーシティ | 抗菌性ポリミキシン誘導体化合物 |
| BR112019004877A2 (pt) * | 2016-09-13 | 2019-06-11 | Centauri Therapeutics Limited | novos compostos e usos terapêuticos dos mesmos |
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| US9234006B2 (en) | 2016-01-12 |
| CO7061068A2 (es) | 2014-09-19 |
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| WO2013072695A1 (en) | 2013-05-23 |
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| JP2014533678A (ja) | 2014-12-15 |
| AU2012338571B2 (en) | 2016-06-16 |
| MX355217B (es) | 2018-04-10 |
| SG11201402390PA (en) | 2014-06-27 |
| KR20140091724A (ko) | 2014-07-22 |
| MX2014005542A (es) | 2014-10-24 |
| JP6185920B2 (ja) | 2017-08-23 |
| AU2012338571A1 (en) | 2014-05-22 |
| IL232278A0 (en) | 2014-06-30 |
| EA024792B1 (ru) | 2016-10-31 |
| CA2855916A1 (en) | 2013-05-23 |
| EP2780357A1 (en) | 2014-09-24 |
| BR112014012016A2 (pt) | 2017-05-16 |
| CN103946233A (zh) | 2014-07-23 |
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