IL232278A0 - History of polymyxin - Google Patents

History of polymyxin

Info

Publication number
IL232278A0
IL232278A0 IL232278A IL23227814A IL232278A0 IL 232278 A0 IL232278 A0 IL 232278A0 IL 232278 A IL232278 A IL 232278A IL 23227814 A IL23227814 A IL 23227814A IL 232278 A0 IL232278 A0 IL 232278A0
Authority
IL
Israel
Prior art keywords
polymyxin derivatives
polymyxin
derivatives
Prior art date
Application number
IL232278A
Other languages
English (en)
Hebrew (he)
Original Assignee
Novacta Biosystems Ltd
Cantab Anti Infectives Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacta Biosystems Ltd, Cantab Anti Infectives Ltd filed Critical Novacta Biosystems Ltd
Publication of IL232278A0 publication Critical patent/IL232278A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL232278A 2011-11-18 2014-04-28 History of polymyxin IL232278A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561361P 2011-11-18 2011-11-18
PCT/GB2012/052844 WO2013072695A1 (en) 2011-11-18 2012-11-16 Polymyxin derivatives

Publications (1)

Publication Number Publication Date
IL232278A0 true IL232278A0 (en) 2014-06-30

Family

ID=47297320

Family Applications (1)

Application Number Title Priority Date Filing Date
IL232278A IL232278A0 (en) 2011-11-18 2014-04-28 History of polymyxin

Country Status (15)

Country Link
US (1) US9234006B2 (enExample)
EP (1) EP2780357A1 (enExample)
JP (1) JP6185920B2 (enExample)
KR (1) KR20140091724A (enExample)
CN (1) CN103946233A (enExample)
AU (1) AU2012338571B2 (enExample)
BR (1) BR112014012016A2 (enExample)
CA (1) CA2855916A1 (enExample)
CO (1) CO7061068A2 (enExample)
EA (1) EA024792B1 (enExample)
IL (1) IL232278A0 (enExample)
MX (1) MX355217B (enExample)
SG (1) SG11201402390PA (enExample)
TW (1) TWI608019B (enExample)
WO (1) WO2013072695A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX355217B (es) 2011-11-18 2018-04-10 New Pharma Licence Holdings Ltd Derivados de polimixina.
HUE059544T2 (hu) * 2013-05-22 2022-11-28 Spero Therapeutics Inc Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal
KR20160135739A (ko) * 2014-03-11 2016-11-28 뉴 파마 라이센스 홀딩스 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
US10047126B2 (en) 2014-04-01 2018-08-14 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
EP3233889B1 (en) * 2014-12-16 2022-07-06 Shanghai MicuRx Pharmaceutical Co., Ltd. Antimicrobial polymyxins for treatment of bacterial infections
FI126143B (en) 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
US10322187B2 (en) 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
JP7367950B2 (ja) 2015-09-29 2023-10-24 モナッシュ ユニバーシティ 抗菌性ポリミキシン誘導体化合物
BR112019004877A2 (pt) * 2016-09-13 2019-06-11 Centauri Therapeutics Limited novos compostos e usos terapêuticos dos mesmos
CN108226315B (zh) * 2016-12-15 2022-04-12 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
WO2019084628A1 (en) * 2017-11-02 2019-05-09 The University Of Queensland Peptide antibiotics
DK3810633T3 (da) 2018-06-25 2024-01-15 Spero Therapeutics Inc Forbindelser
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
CN111072757B (zh) * 2020-01-02 2021-10-15 上海上药第一生化药业有限公司 多黏菌素b组分或其盐及其制备方法和应用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
CN112755174B (zh) * 2021-02-26 2022-11-18 沈阳药科大学 多粘菌素衍生物及其制备方法和应用
WO2022262823A1 (zh) * 2021-06-18 2022-12-22 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
NL2030897B1 (en) * 2022-02-11 2023-08-18 Univ Leiden Antibiotic compounds, formulations and methods of use

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
AU7753787A (en) 1986-08-06 1988-02-24 Jean-Luc Fauchere Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b
US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (enExample) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
JP2007507512A (ja) 2003-09-30 2007-03-29 コーヒ コーポレーション 熱傷を治療するための組成物および方法
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
BRPI0715095B8 (pt) * 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
US8329645B2 (en) 2008-02-08 2012-12-11 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
ES2334547B1 (es) 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.
WO2010075416A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN101851270A (zh) 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
MX355217B (es) 2011-11-18 2018-04-10 New Pharma Licence Holdings Ltd Derivados de polimixina.
HUE059544T2 (hu) * 2013-05-22 2022-11-28 Spero Therapeutics Inc Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal
KR20160135739A (ko) * 2014-03-11 2016-11-28 뉴 파마 라이센스 홀딩스 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Also Published As

Publication number Publication date
EA201490634A1 (ru) 2014-12-30
US9234006B2 (en) 2016-01-12
CO7061068A2 (es) 2014-09-19
TWI608019B (zh) 2017-12-11
US20150031602A1 (en) 2015-01-29
WO2013072695A1 (en) 2013-05-23
TW201326215A (zh) 2013-07-01
JP2014533678A (ja) 2014-12-15
AU2012338571B2 (en) 2016-06-16
MX355217B (es) 2018-04-10
SG11201402390PA (en) 2014-06-27
KR20140091724A (ko) 2014-07-22
MX2014005542A (es) 2014-10-24
JP6185920B2 (ja) 2017-08-23
AU2012338571A1 (en) 2014-05-22
EA024792B1 (ru) 2016-10-31
CA2855916A1 (en) 2013-05-23
EP2780357A1 (en) 2014-09-24
BR112014012016A2 (pt) 2017-05-16
CN103946233A (zh) 2014-07-23

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