TWI572608B - 雙環雜環衍生物、其製備方法及醫療用途 - Google Patents

雙環雜環衍生物、其製備方法及醫療用途 Download PDF

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Publication number
TWI572608B
TWI572608B TW102102986A TW102102986A TWI572608B TW I572608 B TWI572608 B TW I572608B TW 102102986 A TW102102986 A TW 102102986A TW 102102986 A TW102102986 A TW 102102986A TW I572608 B TWI572608 B TW I572608B
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Taiwan
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group
compound
oxa
formula
mmol
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TW102102986A
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English (en)
Chinese (zh)
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TW201333016A (zh
Inventor
艾倫 布朗恩
奧利維亞 克瑞斯比
揚恩 佛瑞切
吉爾伯特 馬森納克
尼可拉斯 莫茲特
艾力克 尼古拉
賽西爾 派斯寇
柏特恩德 維韋特
法布瑞斯 薇薇安
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賽諾菲公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW102102986A 2012-01-26 2013-01-25 雙環雜環衍生物、其製備方法及醫療用途 TWI572608B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1250768A FR2986232B1 (fr) 2012-01-26 2012-01-26 Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
TW201333016A TW201333016A (zh) 2013-08-16
TWI572608B true TWI572608B (zh) 2017-03-01

Family

ID=47997597

Family Applications (1)

Application Number Title Priority Date Filing Date
TW102102986A TWI572608B (zh) 2012-01-26 2013-01-25 雙環雜環衍生物、其製備方法及醫療用途

Country Status (26)

Country Link
US (1) US9120812B2 (pl)
EP (1) EP2807172B1 (pl)
JP (1) JP6068508B2 (pl)
KR (1) KR20140125389A (pl)
CN (1) CN104203958B (pl)
AR (1) AR089782A1 (pl)
AU (1) AU2013213261B2 (pl)
BR (1) BR112014018226A8 (pl)
CA (1) CA2862747A1 (pl)
CY (1) CY1118852T1 (pl)
DK (1) DK2807172T3 (pl)
ES (1) ES2617880T3 (pl)
FR (1) FR2986232B1 (pl)
HR (1) HRP20170288T1 (pl)
HU (1) HUE031917T2 (pl)
IL (1) IL233774A (pl)
LT (1) LT2807172T (pl)
MX (1) MX348841B (pl)
PL (1) PL2807172T3 (pl)
PT (1) PT2807172T (pl)
RU (1) RU2627269C2 (pl)
SG (1) SG11201404325VA (pl)
SI (1) SI2807172T1 (pl)
TW (1) TWI572608B (pl)
UY (1) UY34594A (pl)
WO (1) WO2013111106A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6139789B2 (ja) * 2013-10-16 2017-05-31 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合複素環化合物、その調製方法、医薬組成物及びその使用
CN107001317B (zh) * 2014-09-29 2019-05-24 山东轩竹医药科技有限公司 高选择性取代嘧啶类pi3k抑制剂
US10307707B2 (en) * 2017-05-17 2019-06-04 Thomas P. Daly 1-amino-2-methyl-2-propanol derivatives
EP3849535A4 (en) 2018-09-10 2022-06-29 Mirati Therapeutics, Inc. Combination therapies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1620459A (zh) * 2002-01-18 2005-05-25 杏林制药株式会社 稠合双环嘧啶衍生物
WO2010138487A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2514473C (en) * 2002-11-22 2008-05-27 Japan Tobacco Inc. Fused bicyclic nitrogen-containing heterocycles
EP2382207B1 (en) * 2008-11-11 2015-04-29 Xcovery Holding Company LLC Pi3k/mtor kinase inhibitors
CA2799764A1 (en) * 2010-05-19 2011-11-24 Xcovery Holding Company, Llc. Mtor selective kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1620459A (zh) * 2002-01-18 2005-05-25 杏林制药株式会社 稠合双环嘧啶衍生物
WO2010138487A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE

Also Published As

Publication number Publication date
PT2807172T (pt) 2017-03-06
ES2617880T3 (es) 2017-06-20
SG11201404325VA (en) 2014-08-28
MX2014009084A (es) 2015-02-05
US20140378433A1 (en) 2014-12-25
HRP20170288T1 (hr) 2017-04-21
AU2013213261B2 (en) 2017-07-20
WO2013111106A1 (en) 2013-08-01
RU2627269C2 (ru) 2017-08-04
DK2807172T3 (en) 2017-03-06
JP6068508B2 (ja) 2017-01-25
HUE031917T2 (en) 2017-08-28
SI2807172T1 (sl) 2017-03-31
US9120812B2 (en) 2015-09-01
CA2862747A1 (en) 2013-08-01
BR112014018226A2 (pl) 2017-06-20
MX348841B (es) 2017-06-30
CN104203958B (zh) 2017-05-31
JP2015504914A (ja) 2015-02-16
FR2986232A1 (fr) 2013-08-02
AR089782A1 (es) 2014-09-17
EP2807172A1 (en) 2014-12-03
KR20140125389A (ko) 2014-10-28
PL2807172T3 (pl) 2017-05-31
FR2986232B1 (fr) 2014-02-14
TW201333016A (zh) 2013-08-16
CN104203958A (zh) 2014-12-10
LT2807172T (lt) 2017-03-27
CY1118852T1 (el) 2018-01-10
RU2014134640A (ru) 2016-03-27
UY34594A (es) 2013-09-02
IL233774A (en) 2016-06-30
AU2013213261A1 (en) 2014-08-21
BR112014018226A8 (pt) 2017-07-11
EP2807172B1 (en) 2016-11-30

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