TWI501953B - 環己烷衍生物化合物 - Google Patents

環己烷衍生物化合物 Download PDF

Info

Publication number
TWI501953B
TWI501953B TW100134525A TW100134525A TWI501953B TW I501953 B TWI501953 B TW I501953B TW 100134525 A TW100134525 A TW 100134525A TW 100134525 A TW100134525 A TW 100134525A TW I501953 B TWI501953 B TW I501953B
Authority
TW
Taiwan
Prior art keywords
group
methyl
phenyl
trans
substituted
Prior art date
Application number
TW100134525A
Other languages
English (en)
Chinese (zh)
Other versions
TW201217342A (en
Inventor
Narihiro Toda
Rieko Takano
Takeshi Shida
Takahiro Katagiri
Mitsuhiro Iwamoto
Shinji Ashida
Mami Yamazaki
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of TW201217342A publication Critical patent/TW201217342A/zh
Application granted granted Critical
Publication of TWI501953B publication Critical patent/TWI501953B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
TW100134525A 2010-09-27 2011-09-26 環己烷衍生物化合物 TWI501953B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010215403 2010-09-27

Publications (2)

Publication Number Publication Date
TW201217342A TW201217342A (en) 2012-05-01
TWI501953B true TWI501953B (zh) 2015-10-01

Family

ID=45892891

Family Applications (1)

Application Number Title Priority Date Filing Date
TW100134525A TWI501953B (zh) 2010-09-27 2011-09-26 環己烷衍生物化合物

Country Status (29)

Country Link
US (3) US8710060B2 (OSRAM)
EP (1) EP2623492B1 (OSRAM)
JP (1) JP5753179B2 (OSRAM)
KR (1) KR20130109124A (OSRAM)
CN (1) CN103108866B (OSRAM)
AU (1) AU2011309212B2 (OSRAM)
BR (1) BR112013007145A2 (OSRAM)
CA (1) CA2812898C (OSRAM)
CO (1) CO6690804A2 (OSRAM)
CY (1) CY1115450T1 (OSRAM)
DK (1) DK2623492T3 (OSRAM)
ES (1) ES2478518T3 (OSRAM)
HR (1) HRP20140720T1 (OSRAM)
IL (1) IL225440A (OSRAM)
IN (1) IN2013MN00506A (OSRAM)
MX (1) MX2013003219A (OSRAM)
MY (1) MY157542A (OSRAM)
NZ (1) NZ609596A (OSRAM)
PH (1) PH12013500583A1 (OSRAM)
PL (1) PL2623492T3 (OSRAM)
PT (1) PT2623492E (OSRAM)
RS (1) RS53447B (OSRAM)
RU (1) RU2013119603A (OSRAM)
SG (1) SG188415A1 (OSRAM)
SI (1) SI2623492T1 (OSRAM)
SM (1) SMT201400109B (OSRAM)
TW (1) TWI501953B (OSRAM)
WO (1) WO2012043445A1 (OSRAM)
ZA (1) ZA201301652B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12013500583A1 (en) * 2010-09-27 2013-05-20 Daiichi Sankyo Co Ltd Cyclohexane derivative compound
US10352962B2 (en) 2016-12-29 2019-07-16 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis and feedback
US11318350B2 (en) 2016-12-29 2022-05-03 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US9773330B1 (en) 2016-12-29 2017-09-26 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US10973439B2 (en) 2016-12-29 2021-04-13 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008000729A1 (en) * 2006-06-28 2008-01-03 Glaxo Group Limited Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511980B2 (en) * 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US7262195B2 (en) * 2003-09-17 2007-08-28 Bristol-Myers Squibb Company Compounds useful as motilin agonists and method
GB0611907D0 (en) * 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
GB0515381D0 (en) * 2005-07-26 2005-08-31 Glaxo Group Ltd Compounds
GB0612844D0 (en) * 2006-06-28 2006-08-09 Glaxo Group Ltd Compounds
GB0723317D0 (en) 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
PH12013500583A1 (en) * 2010-09-27 2013-05-20 Daiichi Sankyo Co Ltd Cyclohexane derivative compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008000729A1 (en) * 2006-06-28 2008-01-03 Glaxo Group Limited Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases

Also Published As

Publication number Publication date
IN2013MN00506A (OSRAM) 2015-05-29
JP5753179B2 (ja) 2015-07-22
BR112013007145A2 (pt) 2016-06-14
CO6690804A2 (es) 2013-06-17
HK1185081A1 (en) 2014-02-07
KR20130109124A (ko) 2013-10-07
ES2478518T3 (es) 2014-07-22
SG188415A1 (en) 2013-04-30
EP2623492A4 (en) 2013-09-25
RS53447B (sr) 2014-12-31
HRP20140720T1 (hr) 2014-08-29
CA2812898A1 (en) 2012-04-05
PL2623492T3 (pl) 2014-09-30
US8710060B2 (en) 2014-04-29
IL225440A0 (en) 2013-06-27
WO2012043445A1 (ja) 2012-04-05
AU2011309212A1 (en) 2013-03-21
DK2623492T3 (da) 2014-08-11
US20140221392A1 (en) 2014-08-07
TW201217342A (en) 2012-05-01
US20130289048A1 (en) 2013-10-31
SI2623492T1 (sl) 2014-09-30
RU2013119603A (ru) 2014-11-10
CY1115450T1 (el) 2017-01-04
JPWO2012043445A1 (ja) 2014-02-06
PH12013500583A1 (en) 2013-05-20
US9051255B2 (en) 2015-06-09
PT2623492E (pt) 2014-08-29
ZA201301652B (en) 2014-04-30
SMT201400109B (it) 2014-09-08
CA2812898C (en) 2015-11-17
AU2011309212B2 (en) 2014-06-19
MY157542A (en) 2016-06-15
CN103108866A (zh) 2013-05-15
IL225440A (en) 2015-11-30
CN103108866B (zh) 2015-09-09
US20140221391A1 (en) 2014-08-07
EP2623492B1 (en) 2014-05-14
MX2013003219A (es) 2013-06-18
NZ609596A (en) 2013-12-20
EP2623492A1 (en) 2013-08-07

Similar Documents

Publication Publication Date Title
TWI839461B (zh) Il-17a調節物及其用途
JP6301842B2 (ja) 複素環アミド誘導体及びそれを含有する医薬
CA2787248C (en) Piperazine compound having a pgds inhibitory effect
RU2662817C2 (ru) Соединение дикарбоновой кислоты
JP2011514364A (ja) 置換されたピロリジン及びピペリジン化合物、その誘導体、並びに疼痛を治療するための方法
TWI616435B (zh) 苯基衍生物
CN103108866B (zh) 环己烷衍生物化合物
JP3231775B2 (ja) 心循環器系に作用する２−アミノ−１，２，３，４−テトラヒドロナフタレン誘導体、それらを製造する方法、及びそれらを含む医薬組成物
JP2018138566A (ja) 組成物、合成およびフェニルシクロアルキルメチルアミン誘導体を使用する方法
AU2023395547A1 (en) 2-azabicyclo[3.1.1]heptane compound
EA015600B1 (ru) Агенты, усиливающие действие амра-рецепторов
CA3045887A1 (en) Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
CN115806503A (zh) 一种选择性组蛋白去乙酰化酶抑制剂及其制备方法和应用
CA2603030C (en) Benzyloxypropylamine derivative
HK1185081B (en) Cyclohexane derivative compound
TW202604893A (zh) 經取代吡啶及苯基化合物
RU2778771C2 (ru) Ингибитор ассоциированного с функцией лимфоцитов антигена-1 (lfa-1), способы его получения и его полиморф
BR122025005591B1 (pt) Uso de e processo para preparação de derivados de ciclobutila 1,3- substituída, combinação farmacêutica, e kit
JP2012067054A (ja) スルホンアミド誘導体化合物
MX2011006655A (es) Compuestos de anima ciclica.
HK1201518B (en) Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees