AU2011309212B2 - Cyclohexane derivative compound - Google Patents

Cyclohexane derivative compound Download PDF

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Publication number
AU2011309212B2
AU2011309212B2 AU2011309212A AU2011309212A AU2011309212B2 AU 2011309212 B2 AU2011309212 B2 AU 2011309212B2 AU 2011309212 A AU2011309212 A AU 2011309212A AU 2011309212 A AU2011309212 A AU 2011309212A AU 2011309212 B2 AU2011309212 B2 AU 2011309212B2
Authority
AU
Australia
Prior art keywords
group
methyl
trans
optionally substituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011309212A
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English (en)
Other versions
AU2011309212A1 (en
Inventor
Shinji Ashida
Mitsuhiro Iwamoto
Takahiro Katagiri
Takeshi Shida
Rieko Takano
Narihiro Toda
Mami Yamazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of AU2011309212A1 publication Critical patent/AU2011309212A1/en
Application granted granted Critical
Publication of AU2011309212B2 publication Critical patent/AU2011309212B2/en
Assigned to DAIICHI SANKYO COMPANY, LIMITED reassignment DAIICHI SANKYO COMPANY, LIMITED Amend patent request/document other than specification (104) Assignors: DAIICHI SANKYO COMPANY,LIMITED
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2011309212A 2010-09-27 2011-09-26 Cyclohexane derivative compound Ceased AU2011309212B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010-215403 2010-09-27
JP2010215403 2010-09-27
PCT/JP2011/071830 WO2012043445A1 (ja) 2010-09-27 2011-09-26 シクロヘキサン誘導体化合物

Publications (2)

Publication Number Publication Date
AU2011309212A1 AU2011309212A1 (en) 2013-03-21
AU2011309212B2 true AU2011309212B2 (en) 2014-06-19

Family

ID=45892891

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011309212A Ceased AU2011309212B2 (en) 2010-09-27 2011-09-26 Cyclohexane derivative compound

Country Status (29)

Country Link
US (3) US8710060B2 (OSRAM)
EP (1) EP2623492B1 (OSRAM)
JP (1) JP5753179B2 (OSRAM)
KR (1) KR20130109124A (OSRAM)
CN (1) CN103108866B (OSRAM)
AU (1) AU2011309212B2 (OSRAM)
BR (1) BR112013007145A2 (OSRAM)
CA (1) CA2812898C (OSRAM)
CO (1) CO6690804A2 (OSRAM)
CY (1) CY1115450T1 (OSRAM)
DK (1) DK2623492T3 (OSRAM)
ES (1) ES2478518T3 (OSRAM)
HR (1) HRP20140720T1 (OSRAM)
IL (1) IL225440A (OSRAM)
IN (1) IN2013MN00506A (OSRAM)
MX (1) MX2013003219A (OSRAM)
MY (1) MY157542A (OSRAM)
NZ (1) NZ609596A (OSRAM)
PH (1) PH12013500583A1 (OSRAM)
PL (1) PL2623492T3 (OSRAM)
PT (1) PT2623492E (OSRAM)
RS (1) RS53447B (OSRAM)
RU (1) RU2013119603A (OSRAM)
SG (1) SG188415A1 (OSRAM)
SI (1) SI2623492T1 (OSRAM)
SM (1) SMT201400109B (OSRAM)
TW (1) TWI501953B (OSRAM)
WO (1) WO2012043445A1 (OSRAM)
ZA (1) ZA201301652B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12013500583A1 (en) * 2010-09-27 2013-05-20 Daiichi Sankyo Co Ltd Cyclohexane derivative compound
US10352962B2 (en) 2016-12-29 2019-07-16 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis and feedback
US11318350B2 (en) 2016-12-29 2022-05-03 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US9773330B1 (en) 2016-12-29 2017-09-26 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US10973439B2 (en) 2016-12-29 2021-04-13 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007144400A1 (en) * 2006-06-15 2007-12-21 Glaxo Group Limited Benzylpiperazine derivatives as motilin receptor antagonists
WO2008000729A1 (en) * 2006-06-28 2008-01-03 Glaxo Group Limited Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
WO2009068552A1 (en) * 2007-11-28 2009-06-04 Glaxo Group Limited Piperazinyl-sulfonamide derivatives useful in the treatment of gpr38 receptor mediated diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511980B2 (en) * 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US7262195B2 (en) * 2003-09-17 2007-08-28 Bristol-Myers Squibb Company Compounds useful as motilin agonists and method
GB0515381D0 (en) * 2005-07-26 2005-08-31 Glaxo Group Ltd Compounds
GB0612844D0 (en) * 2006-06-28 2006-08-09 Glaxo Group Ltd Compounds
PH12013500583A1 (en) * 2010-09-27 2013-05-20 Daiichi Sankyo Co Ltd Cyclohexane derivative compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007144400A1 (en) * 2006-06-15 2007-12-21 Glaxo Group Limited Benzylpiperazine derivatives as motilin receptor antagonists
WO2008000729A1 (en) * 2006-06-28 2008-01-03 Glaxo Group Limited Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
WO2009068552A1 (en) * 2007-11-28 2009-06-04 Glaxo Group Limited Piperazinyl-sulfonamide derivatives useful in the treatment of gpr38 receptor mediated diseases

Also Published As

Publication number Publication date
IN2013MN00506A (OSRAM) 2015-05-29
JP5753179B2 (ja) 2015-07-22
BR112013007145A2 (pt) 2016-06-14
CO6690804A2 (es) 2013-06-17
HK1185081A1 (en) 2014-02-07
KR20130109124A (ko) 2013-10-07
ES2478518T3 (es) 2014-07-22
SG188415A1 (en) 2013-04-30
EP2623492A4 (en) 2013-09-25
RS53447B (sr) 2014-12-31
HRP20140720T1 (hr) 2014-08-29
CA2812898A1 (en) 2012-04-05
PL2623492T3 (pl) 2014-09-30
US8710060B2 (en) 2014-04-29
IL225440A0 (en) 2013-06-27
WO2012043445A1 (ja) 2012-04-05
AU2011309212A1 (en) 2013-03-21
DK2623492T3 (da) 2014-08-11
US20140221392A1 (en) 2014-08-07
TW201217342A (en) 2012-05-01
US20130289048A1 (en) 2013-10-31
SI2623492T1 (sl) 2014-09-30
RU2013119603A (ru) 2014-11-10
CY1115450T1 (el) 2017-01-04
JPWO2012043445A1 (ja) 2014-02-06
PH12013500583A1 (en) 2013-05-20
US9051255B2 (en) 2015-06-09
PT2623492E (pt) 2014-08-29
ZA201301652B (en) 2014-04-30
SMT201400109B (it) 2014-09-08
CA2812898C (en) 2015-11-17
MY157542A (en) 2016-06-15
CN103108866A (zh) 2013-05-15
IL225440A (en) 2015-11-30
CN103108866B (zh) 2015-09-09
US20140221391A1 (en) 2014-08-07
EP2623492B1 (en) 2014-05-14
MX2013003219A (es) 2013-06-18
TWI501953B (zh) 2015-10-01
NZ609596A (en) 2013-12-20
EP2623492A1 (en) 2013-08-07

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