ES2478518T3 - Compuesto derivado de ciclohexano - Google Patents

Compuesto derivado de ciclohexano Download PDF

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Publication number
ES2478518T3
ES2478518T3 ES11828999.0T ES11828999T ES2478518T3 ES 2478518 T3 ES2478518 T3 ES 2478518T3 ES 11828999 T ES11828999 T ES 11828999T ES 2478518 T3 ES2478518 T3 ES 2478518T3
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group
alkyl group
optionally substituted
alkyl
groups selected
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Inventor
Narihiro Toda
Rieko Takano
Takeshi Shida
Takahiro Katagiri
Mitsuhiro Iwamoto
Shinji Ashida
Mami Yamazaki
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto representado por la siguiente fórmula general (I) o una sal farmacéuticamente aceptable del mismo: en la que A representa un grupo fenileno (el grupo fenileno puede estar opcionalmente sustituido con 1 a 3 grupos seleccionados de un grupo alquilo C1-C3, un grupo alcoxi C1-C3, y un átomo de halógeno); B representa un grupo heterocíclico de 4 a 10 miembros que contiene 1 a 4 heteroátomos que pueden ser iguales o distintos y están seleccionados de nitrógeno, oxígeno y azufre (el grupo heterocíclico puede estar opcionalmente sustituido con 1 a 5 grupos seleccionados del grupo sustituyente α), un grupo arilo C6-C10 (el grupo arilo puede estar opcionalmente sustituido con 1 a 5 grupos seleccionados del grupo sustituyente α), o un grupo cicloalquilo C3- C10 (el grupo cicloalquilo puede estar opcionalmente sustituido con 1 a 5 grupos seleccionados del grupo sustituyente α); R1 representa un átomo de hidrógeno o un grupo alquilo C1-C3; R2 representa un átomo de hidrógeno o un grupo alquilo C1-C3; R3 representa un grupo alquilo C1-C6, un grupo cicloalquilo C3-C10, un grupo alcoxi C1-C3-alquilo C1-C3, o un grupo hidroxi-alquilo C1-C3; R4 representa un átomo de hidrógeno, un grupo alquilo C1-C6, o un átomo de halógeno; n representa un número entero de 1 a 4; X representa metileno, - O-, -NH-, -N(alquilo C1-C3)-, -C(>=O)-, -S-, -S(O)-, -S(O2)- o un enlace sencillo.

Description

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Claims (1)

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ES11828999.0T 2010-09-27 2011-09-26 Compuesto derivado de ciclohexano Active ES2478518T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010215403 2010-09-27
JP2010215403 2010-09-27
PCT/JP2011/071830 WO2012043445A1 (ja) 2010-09-27 2011-09-26 シクロヘキサン誘導体化合物

Publications (1)

Publication Number Publication Date
ES2478518T3 true ES2478518T3 (es) 2014-07-22

Family

ID=45892891

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11828999.0T Active ES2478518T3 (es) 2010-09-27 2011-09-26 Compuesto derivado de ciclohexano

Country Status (29)

Country Link
US (3) US8710060B2 (es)
EP (1) EP2623492B1 (es)
JP (1) JP5753179B2 (es)
KR (1) KR20130109124A (es)
CN (1) CN103108866B (es)
AU (1) AU2011309212B2 (es)
BR (1) BR112013007145A2 (es)
CA (1) CA2812898C (es)
CO (1) CO6690804A2 (es)
CY (1) CY1115450T1 (es)
DK (1) DK2623492T3 (es)
ES (1) ES2478518T3 (es)
HK (1) HK1185081A1 (es)
HR (1) HRP20140720T1 (es)
IL (1) IL225440A (es)
IN (1) IN2013MN00506A (es)
MX (1) MX2013003219A (es)
MY (1) MY157542A (es)
NZ (1) NZ609596A (es)
PL (1) PL2623492T3 (es)
PT (1) PT2623492E (es)
RS (1) RS53447B (es)
RU (1) RU2013119603A (es)
SG (1) SG188415A1 (es)
SI (1) SI2623492T1 (es)
SM (1) SMT201400109B (es)
TW (1) TWI501953B (es)
WO (1) WO2012043445A1 (es)
ZA (1) ZA201301652B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2812898C (en) * 2010-09-27 2015-11-17 Daiichi Sankyo Company, Limited Cyclohexane derivative compound
US11318350B2 (en) 2016-12-29 2022-05-03 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US10973439B2 (en) 2016-12-29 2021-04-13 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US9773330B1 (en) 2016-12-29 2017-09-26 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis, and feedback
US10352962B2 (en) 2016-12-29 2019-07-16 BioMech Sensor LLC Systems and methods for real-time data quantification, acquisition, analysis and feedback

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511980B2 (en) * 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US7262195B2 (en) * 2003-09-17 2007-08-28 Bristol-Myers Squibb Company Compounds useful as motilin agonists and method
GB0611907D0 (en) * 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
GB0515381D0 (en) * 2005-07-26 2005-08-31 Glaxo Group Ltd Compounds
TWI391386B (zh) 2006-06-28 2013-04-01 Glaxo Group Ltd 化合物
GB0612844D0 (en) * 2006-06-28 2006-08-09 Glaxo Group Ltd Compounds
GB0723317D0 (en) * 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
CA2812898C (en) * 2010-09-27 2015-11-17 Daiichi Sankyo Company, Limited Cyclohexane derivative compound

Also Published As

Publication number Publication date
PL2623492T3 (pl) 2014-09-30
HK1185081A1 (en) 2014-02-07
ZA201301652B (en) 2014-04-30
US20140221391A1 (en) 2014-08-07
TW201217342A (en) 2012-05-01
SMT201400109B (it) 2014-09-08
JPWO2012043445A1 (ja) 2014-02-06
MX2013003219A (es) 2013-06-18
EP2623492B1 (en) 2014-05-14
CN103108866A (zh) 2013-05-15
EP2623492A4 (en) 2013-09-25
MY157542A (en) 2016-06-15
RS53447B (en) 2014-12-31
DK2623492T3 (da) 2014-08-11
NZ609596A (en) 2013-12-20
SG188415A1 (en) 2013-04-30
IN2013MN00506A (es) 2015-05-29
EP2623492A1 (en) 2013-08-07
US20140221392A1 (en) 2014-08-07
US8710060B2 (en) 2014-04-29
CY1115450T1 (el) 2017-01-04
SI2623492T1 (sl) 2014-09-30
CA2812898C (en) 2015-11-17
US20130289048A1 (en) 2013-10-31
KR20130109124A (ko) 2013-10-07
PT2623492E (pt) 2014-08-29
RU2013119603A (ru) 2014-11-10
JP5753179B2 (ja) 2015-07-22
CA2812898A1 (en) 2012-04-05
HRP20140720T1 (hr) 2014-08-29
AU2011309212A1 (en) 2013-03-21
WO2012043445A1 (ja) 2012-04-05
CN103108866B (zh) 2015-09-09
US9051255B2 (en) 2015-06-09
BR112013007145A2 (pt) 2016-06-14
CO6690804A2 (es) 2013-06-17
TWI501953B (zh) 2015-10-01
IL225440A0 (en) 2013-06-27
IL225440A (en) 2015-11-30
AU2011309212B2 (en) 2014-06-19

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