DK2279187T3 - Spirocykliske derivater som histondeacetylaseinhibitorer - Google Patents
Spirocykliske derivater som histondeacetylaseinhibitorerInfo
- Publication number
- DK2279187T3 DK2279187T3 DK09732840T DK09732840T DK2279187T3 DK 2279187 T3 DK2279187 T3 DK 2279187T3 DK 09732840 T DK09732840 T DK 09732840T DK 09732840 T DK09732840 T DK 09732840T DK 2279187 T3 DK2279187 T3 DK 2279187T3
- Authority
- DK
- Denmark
- Prior art keywords
- heteroaryl
- aryl
- histone deacetylase
- deacetylase inhibitors
- spirocyclic derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20080154528 EP2110377A1 (en) | 2008-04-15 | 2008-04-15 | Spirocyclic derivatives as histone deacetylase inhibitors |
PCT/EP2009/054376 WO2009127609A1 (en) | 2008-04-15 | 2009-04-14 | Spirocyclic derivatives as histone deacetylase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2279187T3 true DK2279187T3 (da) | 2012-08-06 |
Family
ID=39699884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09732840T DK2279187T3 (da) | 2008-04-15 | 2009-04-14 | Spirocykliske derivater som histondeacetylaseinhibitorer |
Country Status (21)
Country | Link |
---|---|
US (2) | US8592444B2 (da) |
EP (2) | EP2110377A1 (da) |
JP (1) | JP5564036B2 (da) |
KR (1) | KR20110019730A (da) |
CN (1) | CN102026998B (da) |
AT (1) | ATE555113T1 (da) |
AU (1) | AU2009237675B2 (da) |
BR (1) | BRPI0910871A2 (da) |
CA (1) | CA2721467A1 (da) |
DK (1) | DK2279187T3 (da) |
ES (1) | ES2386406T3 (da) |
HK (1) | HK1153739A1 (da) |
IL (1) | IL208636A (da) |
MX (1) | MX2010010494A (da) |
NZ (1) | NZ589240A (da) |
PL (1) | PL2279187T3 (da) |
PT (1) | PT2279187E (da) |
RU (1) | RU2010146193A (da) |
SI (1) | SI2279187T1 (da) |
WO (1) | WO2009127609A1 (da) |
ZA (1) | ZA201008012B (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ542445A (en) | 2003-04-07 | 2008-03-28 | Pharmacyclics Inc | Hydroxamates as therapeutic agents |
AU2007340129B2 (en) | 2006-12-26 | 2012-02-02 | Pharmacyclics Llc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
US8980877B2 (en) | 2008-04-15 | 2015-03-17 | Dac S.R.L. | Spirocyclic derivatives as histone deacetylase inhibitors |
EP2110377A1 (en) * | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
EP2311840A1 (en) | 2009-10-13 | 2011-04-20 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
WO2010103381A1 (en) * | 2009-03-13 | 2010-09-16 | Glenmark Pharmaceuticals S.A. | Spirocyclic piperidine derivatives as trpm 8 modulators |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
US8999889B2 (en) | 2010-02-01 | 2015-04-07 | Basf Se | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests |
HUE056525T2 (hu) | 2010-04-07 | 2022-02-28 | Vertex Pharma | 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)ciklopropánkarboxamido)-3-metilpiridin-2-il)benzoesav gyógyszerészeti készítményei és azok adagolása |
EP2595989B1 (en) | 2010-05-06 | 2016-07-13 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
PT2670752E (pt) | 2011-02-02 | 2016-06-14 | Vertex Pharma | Piperidinamidas pirrolopirazina-espirocíclicas como moduladores de canais iónicos |
US10385070B2 (en) | 2011-02-18 | 2019-08-20 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
CN103517910B (zh) | 2011-03-14 | 2016-12-14 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吗啉-螺环哌啶酰胺 |
SG2014014419A (en) | 2011-09-13 | 2014-07-30 | Pharmacyclics Inc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
CA2868302A1 (en) | 2012-03-23 | 2013-09-26 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
WO2014004376A2 (en) | 2012-06-26 | 2014-01-03 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
CN104955826B (zh) | 2013-02-04 | 2019-05-31 | 默克专利股份公司 | 可用于治疗神经学疾病和病症的螺-喹唑酮衍生物 |
WO2014168986A1 (en) | 2013-04-08 | 2014-10-16 | Brown Dennis M | Therapeutic benefit of suboptimally administered chemical compounds |
TWI649081B (zh) | 2013-08-02 | 2019-02-01 | 製藥公司 | 治療固態腫瘤之方法 |
AU2016215432B2 (en) | 2015-02-02 | 2020-07-30 | Valo Early Discovery, Inc. | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
AR103598A1 (es) | 2015-02-02 | 2017-05-24 | Forma Therapeutics Inc | Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac |
TW201643138A (zh) * | 2015-04-17 | 2016-12-16 | 佛瑪治療公司 | 作為組蛋白脫乙醯基酶(hdac)抑制劑之3-螺-7-異羥肟酸四氫萘 |
US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
WO2018213442A1 (en) * | 2017-05-16 | 2018-11-22 | The University Of Chicago | Highly diastereoselective construction of the 4,5-spirocycle via palladium-catalyzed intramolecular alkenylation |
HU231333B1 (hu) * | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004113336A1 (en) * | 2003-06-16 | 2004-12-29 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
ITMI20060621A1 (it) * | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
CA2651681A1 (en) * | 2006-05-18 | 2007-11-29 | Merck & Co., Inc. | Aryl-fused spirocyclic compounds |
EP2110377A1 (en) * | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
US8980877B2 (en) * | 2008-04-15 | 2015-03-17 | Dac S.R.L. | Spirocyclic derivatives as histone deacetylase inhibitors |
-
2008
- 2008-04-15 EP EP20080154528 patent/EP2110377A1/en not_active Withdrawn
-
2009
- 2009-04-14 EP EP20090732840 patent/EP2279187B9/en not_active Not-in-force
- 2009-04-14 US US12/988,197 patent/US8592444B2/en active Active
- 2009-04-14 PL PL09732840T patent/PL2279187T3/pl unknown
- 2009-04-14 SI SI200930287T patent/SI2279187T1/sl unknown
- 2009-04-14 BR BRPI0910871A patent/BRPI0910871A2/pt not_active IP Right Cessation
- 2009-04-14 RU RU2010146193/04A patent/RU2010146193A/ru not_active Application Discontinuation
- 2009-04-14 AT AT09732840T patent/ATE555113T1/de active
- 2009-04-14 DK DK09732840T patent/DK2279187T3/da active
- 2009-04-14 PT PT09732840T patent/PT2279187E/pt unknown
- 2009-04-14 WO PCT/EP2009/054376 patent/WO2009127609A1/en active Application Filing
- 2009-04-14 AU AU2009237675A patent/AU2009237675B2/en not_active Ceased
- 2009-04-14 MX MX2010010494A patent/MX2010010494A/es active IP Right Grant
- 2009-04-14 JP JP2011504434A patent/JP5564036B2/ja not_active Expired - Fee Related
- 2009-04-14 CA CA 2721467 patent/CA2721467A1/en not_active Abandoned
- 2009-04-14 KR KR20107025354A patent/KR20110019730A/ko not_active Application Discontinuation
- 2009-04-14 ES ES09732840T patent/ES2386406T3/es active Active
- 2009-04-14 CN CN2009801133135A patent/CN102026998B/zh not_active Expired - Fee Related
- 2009-04-14 NZ NZ589240A patent/NZ589240A/en not_active IP Right Cessation
-
2010
- 2010-10-11 IL IL208636A patent/IL208636A/en not_active IP Right Cessation
- 2010-11-09 ZA ZA2010/08012A patent/ZA201008012B/en unknown
-
2011
- 2011-07-28 HK HK11107831A patent/HK1153739A1/xx not_active IP Right Cessation
-
2013
- 2013-11-22 US US14/088,061 patent/US9115148B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE555113T1 (de) | 2012-05-15 |
US8592444B2 (en) | 2013-11-26 |
EP2279187B9 (en) | 2012-12-12 |
CN102026998A (zh) | 2011-04-20 |
HK1153739A1 (en) | 2012-04-05 |
US9115148B2 (en) | 2015-08-25 |
EP2279187B1 (en) | 2012-04-25 |
KR20110019730A (ko) | 2011-02-28 |
ES2386406T3 (es) | 2012-08-20 |
CN102026998B (zh) | 2013-05-22 |
SI2279187T1 (sl) | 2012-09-28 |
JP2011516594A (ja) | 2011-05-26 |
WO2009127609A1 (en) | 2009-10-22 |
US20110039840A1 (en) | 2011-02-17 |
IL208636A0 (en) | 2010-12-30 |
EP2279187A1 (en) | 2011-02-02 |
PL2279187T3 (pl) | 2012-09-28 |
US20140080823A1 (en) | 2014-03-20 |
BRPI0910871A2 (pt) | 2015-10-06 |
PT2279187E (pt) | 2012-08-02 |
JP5564036B2 (ja) | 2014-07-30 |
IL208636A (en) | 2014-04-30 |
MX2010010494A (es) | 2010-11-04 |
ZA201008012B (en) | 2011-07-27 |
EP2110377A1 (en) | 2009-10-21 |
RU2010146193A (ru) | 2012-05-20 |
AU2009237675B2 (en) | 2013-05-02 |
NZ589240A (en) | 2011-06-30 |
AU2009237675A1 (en) | 2009-10-22 |
CA2721467A1 (en) | 2009-10-22 |
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