TWI464161B - 醛去氫酶活性之調節劑及其使用方法 - Google Patents

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Publication number

TWI464161B

TWI464161B TW098130086A TW98130086A TWI464161B TW I464161 B TWI464161 B TW I464161B TW 098130086 A TW098130086 A TW 098130086A TW 98130086 A TW98130086 A TW 98130086A TW I464161 B TWI464161 B TW I464161B

Authority

TW

Taiwan

Prior art keywords

group

subject

substituted

aldehyde dehydrogenase

alkyl

Prior art date

2008-09-08

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• 108020002663 Aldehyde Dehydrogenase Proteins 0.000 title claims description 123
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• 238000000034 method Methods 0.000 title claims description 73
• 150000001875 compounds Chemical class 0.000 claims description 163
• -1 decyloxy, carboxy, oxycarboxy, protected carboxy, carboxymethyl Chemical group 0.000 claims description 101
• 230000002255 enzymatic effect Effects 0.000 claims description 76
• 125000000217 alkyl group Chemical group 0.000 claims description 51
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• 229920001184 polypeptide Polymers 0.000 claims description 39
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 39
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 39
• 125000003277 amino group Chemical group 0.000 claims description 38
• 239000008194 pharmaceutical composition Substances 0.000 claims description 37
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• 150000002367 halogens Chemical class 0.000 claims description 27
• 230000000302 ischemic effect Effects 0.000 claims description 27
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 21
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