ES2477552T3 - Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos - Google Patents

Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos Download PDF

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Publication number
ES2477552T3
ES2477552T3 ES09812233.6T ES09812233T ES2477552T3 ES 2477552 T3 ES2477552 T3 ES 2477552T3 ES 09812233 T ES09812233 T ES 09812233T ES 2477552 T3 ES2477552 T3 ES 2477552T3
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approximately
substituted
group
subject
amino
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ES09812233.6T
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English (en)
Spanish (es)
Inventor
Wenjin Yang
Che-Hong Chen
Daria Mochly-Rosen
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
ES09812233.6T 2008-09-08 2009-09-03 Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos Active ES2477552T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9522708P 2008-09-08 2008-09-08
US95227P 2008-09-08
PCT/US2009/055927 WO2010028175A1 (en) 2008-09-08 2009-09-03 Modulators of aldehyde dehydrogenase activity and methods of use thereof

Publications (1)

Publication Number Publication Date
ES2477552T3 true ES2477552T3 (es) 2014-07-17

Family

ID=41797485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09812233.6T Active ES2477552T3 (es) 2008-09-08 2009-09-03 Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos

Country Status (7)

Country Link
US (3) US8354435B2 (OSRAM)
EP (1) EP2337563B1 (OSRAM)
JP (2) JP2012502048A (OSRAM)
CN (1) CN102209541B (OSRAM)
ES (1) ES2477552T3 (OSRAM)
TW (1) TWI464161B (OSRAM)
WO (1) WO2010028175A1 (OSRAM)

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JP2012506856A (ja) 2008-10-28 2012-03-22 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法
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US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物
FR3054564B1 (fr) 2016-07-28 2018-08-31 Advanced Biodesign Substrat specifique d'une isoenzyme de l'aldh
CN117105868A (zh) * 2022-05-24 2023-11-24 中国人民解放军海军军医大学 酰胺类醛脱氢酶激动剂、其合成方法及用途
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Also Published As

Publication number Publication date
JP2012502048A (ja) 2012-01-26
US20100063100A1 (en) 2010-03-11
US8906942B2 (en) 2014-12-09
TW201022250A (en) 2010-06-16
EP2337563A1 (en) 2011-06-29
JP2015051983A (ja) 2015-03-19
US20130253010A1 (en) 2013-09-26
EP2337563B1 (en) 2014-04-09
TWI464161B (zh) 2014-12-11
US8354435B2 (en) 2013-01-15
US9345693B2 (en) 2016-05-24
US20150182511A1 (en) 2015-07-02
CN102209541B (zh) 2016-05-18
EP2337563A4 (en) 2012-09-12
WO2010028175A1 (en) 2010-03-11
CN102209541A (zh) 2011-10-05

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