TWI453201B - 可作為Hsp90之抑制劑之異吲哚衍生物 - Google Patents
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- TWI453201B TWI453201B TW098112063A TW98112063A TWI453201B TW I453201 B TWI453201 B TW I453201B TW 098112063 A TW098112063 A TW 098112063A TW 98112063 A TW98112063 A TW 98112063A TW I453201 B TWI453201 B TW I453201B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4425608P | 2008-04-11 | 2008-04-11 | |
| GBGB0806527.8A GB0806527D0 (en) | 2008-04-11 | 2008-04-11 | Pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201002688A TW201002688A (en) | 2010-01-16 |
| TWI453201B true TWI453201B (zh) | 2014-09-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098112063A TWI453201B (zh) | 2008-04-11 | 2009-04-10 | 可作為Hsp90之抑制劑之異吲哚衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8383619B2 (enExample) |
| EP (1) | EP2271618B1 (enExample) |
| JP (1) | JP5653903B2 (enExample) |
| CY (1) | CY1115256T1 (enExample) |
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| ES2523565T3 (es) * | 2005-04-13 | 2014-11-27 | Astex Therapeutics Limited | Derivados de hidroxibenzamida y sus usos como inhibidores de la hsp90 |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| GB201009853D0 (en) * | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| US9044474B2 (en) * | 2010-11-08 | 2015-06-02 | The Ohio State University | Compositions and methods for increasing drug efficacy in cancer |
| US10729692B2 (en) * | 2017-02-26 | 2020-08-04 | Institute For Cancer Research | Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death |
| AU2021211925A1 (en) * | 2020-01-20 | 2022-08-25 | Neophore Limited | Isoindoline derivatives which bind to an ATP binding site |
| US20230183197A1 (en) * | 2020-06-01 | 2023-06-15 | Neophore Limited | Inhibitors of mlh1 and/or pms2 for cancer treatment |
| GB202110373D0 (en) * | 2021-07-19 | 2021-09-01 | Neophore Ltd | Inhibitor compounds |
| GB202117224D0 (en) * | 2021-11-29 | 2022-01-12 | Neophore Ltd | Inhibitor compounds |
| GB202117225D0 (en) * | 2021-11-29 | 2022-01-12 | Neophore Ltd | Protac compounds |
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| WO2006109085A1 (en) * | 2005-04-13 | 2006-10-19 | Astex Therapeutics Limited | Hydroxybenzamide derivatives and their use as inhibitors of hsp90 |
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| JP2011516536A (ja) | 2011-05-26 |
| DK2271618T3 (da) | 2014-06-16 |
| JP5653903B2 (ja) | 2015-01-14 |
| EP2271618B1 (en) | 2014-05-21 |
| WO2009125230A1 (en) | 2009-10-15 |
| US8664218B2 (en) | 2014-03-04 |
| SI2271618T1 (sl) | 2014-07-31 |
| US8383619B2 (en) | 2013-02-26 |
| TW201002688A (en) | 2010-01-16 |
| RS53389B (sr) | 2014-10-31 |
| PT2271618E (pt) | 2014-07-28 |
| US20130210820A1 (en) | 2013-08-15 |
| PL2271618T3 (pl) | 2014-09-30 |
| CY1115256T1 (el) | 2017-01-04 |
| GB0806527D0 (en) | 2008-05-14 |
| EP2271618A1 (en) | 2011-01-12 |
| HRP20140516T1 (hr) | 2014-07-04 |
| ES2469797T3 (es) | 2014-06-20 |
| US20110098290A1 (en) | 2011-04-28 |
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