ES2469797T3 - Compuestos farmacéuticos - Google Patents
Compuestos farmacéuticos Download PDFInfo
- Publication number
- ES2469797T3 ES2469797T3 ES09731468.6T ES09731468T ES2469797T3 ES 2469797 T3 ES2469797 T3 ES 2469797T3 ES 09731468 T ES09731468 T ES 09731468T ES 2469797 T3 ES2469797 T3 ES 2469797T3
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- ES
- Spain
- Prior art keywords
- methyl
- isopropyl
- ylmethyl
- piperazin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 27
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 22
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- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US4425608P | 2008-04-11 | 2008-04-11 | |
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| GB0806527 | 2008-04-11 | ||
| PCT/GB2009/050358 WO2009125230A1 (en) | 2008-04-11 | 2009-04-09 | Pharmaceutical compounds |
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| SI (1) | SI2271618T1 (enExample) |
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| CN101193862B (zh) * | 2005-04-13 | 2013-08-21 | 阿斯特克斯治疗有限公司 | 羟基苯甲酰胺衍生物和其作为hsp90抑制剂的用途 |
| US9730912B2 (en) | 2006-10-12 | 2017-08-15 | Astex Therapeutics Limited | Pharmaceutical compounds |
| GB201009853D0 (en) * | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| US9044474B2 (en) * | 2010-11-08 | 2015-06-02 | The Ohio State University | Compositions and methods for increasing drug efficacy in cancer |
| US10729692B2 (en) * | 2017-02-26 | 2020-08-04 | Institute For Cancer Research | Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death |
| AU2021211925A1 (en) * | 2020-01-20 | 2022-08-25 | Neophore Limited | Isoindoline derivatives which bind to an ATP binding site |
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-
2009
- 2009-04-09 SI SI200930943T patent/SI2271618T1/sl unknown
- 2009-04-09 WO PCT/GB2009/050358 patent/WO2009125230A1/en not_active Ceased
- 2009-04-09 PT PT97314686T patent/PT2271618E/pt unknown
- 2009-04-09 EP EP09731468.6A patent/EP2271618B1/en active Active
- 2009-04-09 RS RS20140346A patent/RS53389B/sr unknown
- 2009-04-09 HR HRP20140516AT patent/HRP20140516T1/hr unknown
- 2009-04-09 PL PL09731468T patent/PL2271618T3/pl unknown
- 2009-04-09 DK DK09731468.6T patent/DK2271618T3/da active
- 2009-04-09 JP JP2011503505A patent/JP5653903B2/ja not_active Expired - Fee Related
- 2009-04-09 ES ES09731468.6T patent/ES2469797T3/es active Active
- 2009-04-10 TW TW098112063A patent/TWI453201B/zh not_active IP Right Cessation
-
2010
- 2010-10-12 US US12/902,658 patent/US8383619B2/en not_active Expired - Fee Related
-
2013
- 2013-01-30 US US13/753,904 patent/US8664218B2/en not_active Expired - Fee Related
-
2014
- 2014-07-07 CY CY20141100506T patent/CY1115256T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2271618B1 (en) | 2014-05-21 |
| JP2011516536A (ja) | 2011-05-26 |
| US20130210820A1 (en) | 2013-08-15 |
| TW201002688A (en) | 2010-01-16 |
| EP2271618A1 (en) | 2011-01-12 |
| SI2271618T1 (sl) | 2014-07-31 |
| RS53389B (sr) | 2014-10-31 |
| US20110098290A1 (en) | 2011-04-28 |
| WO2009125230A1 (en) | 2009-10-15 |
| JP5653903B2 (ja) | 2015-01-14 |
| US8383619B2 (en) | 2013-02-26 |
| CY1115256T1 (el) | 2017-01-04 |
| PL2271618T3 (pl) | 2014-09-30 |
| DK2271618T3 (da) | 2014-06-16 |
| US8664218B2 (en) | 2014-03-04 |
| HRP20140516T1 (hr) | 2014-07-04 |
| TWI453201B (zh) | 2014-09-21 |
| PT2271618E (pt) | 2014-07-28 |
| GB0806527D0 (en) | 2008-05-14 |
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