CY1115256T1 - Φαρμακευτικες ενωσεις - Google Patents

Φαρμακευτικες ενωσεις

Info

Publication number
CY1115256T1
CY1115256T1 CY20141100506T CY141100506T CY1115256T1 CY 1115256 T1 CY1115256 T1 CY 1115256T1 CY 20141100506 T CY20141100506 T CY 20141100506T CY 141100506 T CY141100506 T CY 141100506T CY 1115256 T1 CY1115256 T1 CY 1115256T1
Authority
CY
Cyprus
Prior art keywords
alkyl
hydrogen
different
ring
nr4r5
Prior art date
Application number
CY20141100506T
Other languages
Greek (el)
English (en)
Inventor
Martyn Frederickson
Original Assignee
Astex Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Limited filed Critical Astex Therapeutics Limited
Publication of CY1115256T1 publication Critical patent/CY1115256T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY20141100506T 2008-04-11 2014-07-07 Φαρμακευτικες ενωσεις CY1115256T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4425608P 2008-04-11 2008-04-11
GBGB0806527.8A GB0806527D0 (en) 2008-04-11 2008-04-11 Pharmaceutical compounds
EP09731468.6A EP2271618B1 (en) 2008-04-11 2009-04-09 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
CY1115256T1 true CY1115256T1 (el) 2017-01-04

Family

ID=39433425

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100506T CY1115256T1 (el) 2008-04-11 2014-07-07 Φαρμακευτικες ενωσεις

Country Status (14)

Country Link
US (2) US8383619B2 (enExample)
EP (1) EP2271618B1 (enExample)
JP (1) JP5653903B2 (enExample)
CY (1) CY1115256T1 (enExample)
DK (1) DK2271618T3 (enExample)
ES (1) ES2469797T3 (enExample)
GB (1) GB0806527D0 (enExample)
HR (1) HRP20140516T1 (enExample)
PL (1) PL2271618T3 (enExample)
PT (1) PT2271618E (enExample)
RS (1) RS53389B (enExample)
SI (1) SI2271618T1 (enExample)
TW (1) TWI453201B (enExample)
WO (1) WO2009125230A1 (enExample)

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CN101193862B (zh) * 2005-04-13 2013-08-21 阿斯特克斯治疗有限公司 羟基苯甲酰胺衍生物和其作为hsp90抑制剂的用途
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
GB201009853D0 (en) * 2010-06-11 2010-07-21 Chroma Therapeutics Ltd HSP90 inhibitors
US9044474B2 (en) * 2010-11-08 2015-06-02 The Ohio State University Compositions and methods for increasing drug efficacy in cancer
US10729692B2 (en) 2017-02-26 2020-08-04 Institute For Cancer Research Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death
EP4093731A1 (en) * 2020-01-20 2022-11-30 Neophore Limited Isoindoline derivatives which bind to an atp binding site
GB202008201D0 (en) * 2020-06-01 2020-07-15 Neophore Ltd Inhibitor compounds
GB202110373D0 (en) * 2021-07-19 2021-09-01 Neophore Ltd Inhibitor compounds
GB202117225D0 (en) * 2021-11-29 2022-01-12 Neophore Ltd Protac compounds
GB202117224D0 (en) * 2021-11-29 2022-01-12 Neophore Ltd Inhibitor compounds

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Also Published As

Publication number Publication date
SI2271618T1 (sl) 2014-07-31
EP2271618B1 (en) 2014-05-21
RS53389B (sr) 2014-10-31
ES2469797T3 (es) 2014-06-20
US8383619B2 (en) 2013-02-26
HRP20140516T1 (hr) 2014-07-04
EP2271618A1 (en) 2011-01-12
TW201002688A (en) 2010-01-16
GB0806527D0 (en) 2008-05-14
US8664218B2 (en) 2014-03-04
PT2271618E (pt) 2014-07-28
JP2011516536A (ja) 2011-05-26
WO2009125230A1 (en) 2009-10-15
JP5653903B2 (ja) 2015-01-14
PL2271618T3 (pl) 2014-09-30
US20130210820A1 (en) 2013-08-15
TWI453201B (zh) 2014-09-21
US20110098290A1 (en) 2011-04-28
DK2271618T3 (da) 2014-06-16

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