TWI415833B - 脂氧素（ｌｉｐｏｘｉｎ）ａ4類似物之結晶鉀鹽 - Google Patents

脂氧素（ｌｉｐｏｘｉｎ）ａ4類似物之結晶鉀鹽 Download PDF

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Publication number
TWI415833B
TWI415833B TW096146154A TW96146154A TWI415833B TW I415833 B TWI415833 B TW I415833B TW 096146154 A TW096146154 A TW 096146154A TW 96146154 A TW96146154 A TW 96146154A TW I415833 B TWI415833 B TW I415833B
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Prior art keywords
potassium salt
ray powder
powder diffraction
diffraction pattern
crystalline potassium
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TW096146154A
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Chinese (zh)
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TW200838847A (en
Inventor
哈客 堤洛
葛洛司貝區 丹賈
溫特 加布立爾
山得 邁可
貝克曼 沃夫岡
巴特爾 克勞斯
丁特 克力斯坦
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拜耳知識產權公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
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    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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TW096146154A 2006-12-04 2007-12-04 脂氧素（ｌｉｐｏｘｉｎ）ａ4類似物之結晶鉀鹽 TWI415833B (zh)

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US87283006P 2006-12-04 2006-12-04

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TW200838847A TW200838847A (en) 2008-10-01
TWI415833B true TWI415833B (zh) 2013-11-21

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TW096146154A TWI415833B (zh) 2006-12-04 2007-12-04 脂氧素（ｌｉｐｏｘｉｎ）ａ4類似物之結晶鉀鹽

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US (2) US7906678B2 (enExample)
EP (2) EP2089350B1 (enExample)
JP (1) JP5410984B2 (enExample)
KR (3) KR20090101169A (enExample)
CN (1) CN101553456B (enExample)
AR (1) AR064116A1 (enExample)
AU (1) AU2007327765B2 (enExample)
BR (1) BRPI0719679A2 (enExample)
CA (1) CA2670791C (enExample)
CL (1) CL2007003468A1 (enExample)
CO (1) CO6190608A2 (enExample)
CR (1) CR10837A (enExample)
DO (1) DOP2009000130A (enExample)
EA (1) EA018615B1 (enExample)
EC (1) ECSP099380A (enExample)
IL (1) IL198434A (enExample)
MA (1) MA31079B1 (enExample)
MX (1) MX2009005911A (enExample)
MY (1) MY147951A (enExample)
NO (1) NO20092528L (enExample)
NZ (1) NZ577338A (enExample)
PE (2) PE20081200A1 (enExample)
SV (1) SV2009003286A (enExample)
TN (1) TN2009000167A1 (enExample)
TW (1) TWI415833B (enExample)
UY (1) UY30755A1 (enExample)
WO (1) WO2008068041A1 (enExample)
ZA (1) ZA200904689B (enExample)

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US7906678B2 (en) * 2006-12-04 2011-03-15 Bayer Schering Pharma Aktiengesellschaft Crystalline potassium salt of lipoxin A4 analogs
US20090036530A1 (en) * 2006-12-04 2009-02-05 Bayer Schering Pharma Aktiengesellschaft Crystalline acid of lipoxin A4 analogs and method of making
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2470189A4 (en) * 2009-08-27 2013-01-23 Merck Sharp & Dohme METHOD FOR PRODUCING PROTEASE INHIBITORS OF HEPATITIS C VIRUS
DK2958560T3 (da) * 2013-02-21 2019-08-12 Forsyth Dental Infirmary For Children Fremgangsmåder til at øge oral osteogenese under anvendelse af lipoxin a4 (lxa4) og dets analoger
CN107438366B (zh) * 2015-03-18 2022-03-15 福塞斯儿童牙科医院 使用脂氧素、消退素及其类似物稳定动脉粥状硬化斑块的方法
KR102437682B1 (ko) * 2016-06-03 2022-08-29 테티스 파마수티컬스 엘엘씨 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법
US11519911B2 (en) 2017-01-31 2022-12-06 The Brigham And Women's Hospital, Inc. ALX receptor ligands define a biochemical endotype for inflammation-based diseases
CN111875530A (zh) * 2020-08-17 2020-11-03 浙江朗华制药有限公司 一种普拉西坦水合物晶体及其制备方法

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WO2003040080A2 (en) * 2001-11-06 2003-05-15 Schering Aktiengesellschaft Lipoxin a4 analogs

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ZA200904689B (en) 2011-10-26
CL2007003468A1 (es) 2008-07-04
KR20140135847A (ko) 2014-11-26
PE20120395A1 (es) 2012-05-23
MX2009005911A (es) 2009-09-07
MY147951A (en) 2013-02-15
US8049035B2 (en) 2011-11-01
IL198434A (en) 2012-09-24
WO2008068041A1 (en) 2008-06-12
BRPI0719679A2 (pt) 2014-01-14
EP2089350A1 (en) 2009-08-19
JP2010511649A (ja) 2010-04-15
EA018615B1 (ru) 2013-09-30
US7906678B2 (en) 2011-03-15
CA2670791C (en) 2017-01-03
KR20160054030A (ko) 2016-05-13
KR20090101169A (ko) 2009-09-24
TN2009000167A1 (en) 2010-10-18
US20110124910A1 (en) 2011-05-26
CN101553456B (zh) 2013-08-28
CA2670791A1 (en) 2008-06-12
AU2007327765B2 (en) 2012-04-12
AR064116A1 (es) 2009-03-11
EA200900732A1 (ru) 2009-12-30
SV2009003286A (es) 2009-10-02
TW200838847A (en) 2008-10-01
DOP2009000130A (es) 2009-08-15
EP2089350B1 (en) 2018-08-22
US20080182897A1 (en) 2008-07-31
CN101553456A (zh) 2009-10-07
CO6190608A2 (es) 2010-08-19
AU2007327765A1 (en) 2008-06-12
MA31079B1 (fr) 2010-01-04
CR10837A (es) 2009-07-23
NZ577338A (en) 2011-02-25
HK1135961A1 (en) 2010-06-18
EP3489214A1 (en) 2019-05-29
PE20081200A1 (es) 2008-11-06
JP5410984B2 (ja) 2014-02-05
ECSP099380A (es) 2009-11-30
IL198434A0 (en) 2010-02-17
UY30755A1 (es) 2008-07-31

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