TWI392682B - 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 - Google Patents

作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 Download PDF

Info

Publication number
TWI392682B
TWI392682B TW096110303A TW96110303A TWI392682B TW I392682 B TWI392682 B TW I392682B TW 096110303 A TW096110303 A TW 096110303A TW 96110303 A TW96110303 A TW 96110303A TW I392682 B TWI392682 B TW I392682B
Authority
TW
Taiwan
Prior art keywords
androstane
hydroxy
group
compound
methylandrostane
Prior art date
Application number
TW096110303A
Other languages
English (en)
Chinese (zh)
Other versions
TW200804406A (en
Inventor
Alberto Cerri
Marco Torri
Silvia Armaroli
Giuseppe Bianchi
Patrizia Ferrari
Maria Pia Zappavigna
Simona Sputore
Rosamaria Micheletti
Leonardo Banfi
Giulio Carzana
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of TW200804406A publication Critical patent/TW200804406A/zh
Application granted granted Critical
Publication of TWI392682B publication Critical patent/TWI392682B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW096110303A 2006-04-13 2007-03-26 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 TWI392682B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112598 2006-04-13

Publications (2)

Publication Number Publication Date
TW200804406A TW200804406A (en) 2008-01-16
TWI392682B true TWI392682B (zh) 2013-04-11

Family

ID=37268538

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096110303A TWI392682B (zh) 2006-04-13 2007-03-26 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物

Country Status (16)

Country Link
US (1) US8609644B2 (enExample)
EP (1) EP2004668B1 (enExample)
JP (1) JP5438503B2 (enExample)
KR (1) KR101424046B1 (enExample)
CN (1) CN101466725B (enExample)
AR (1) AR060427A1 (enExample)
AU (1) AU2007239518B2 (enExample)
BR (1) BRPI0709943A2 (enExample)
CA (1) CA2649175C (enExample)
EA (1) EA015257B1 (enExample)
ES (1) ES2405625T3 (enExample)
MX (1) MX2008012942A (enExample)
PL (1) PL2004668T3 (enExample)
PT (1) PT2004668E (enExample)
TW (1) TWI392682B (enExample)
WO (1) WO2007118832A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
JP5290189B2 (ja) * 2006-11-30 2013-09-18 エンディース エルエルシー ６−アルコキシアルキルエストラジオール誘導体およびその使用
JP5738267B2 (ja) * 2009-03-23 2015-06-24 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ タンパク尿、糸球体硬化、及び腎不全の治療に有用な５−β，１４−β−アンドロスタン誘導体
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
WO2017149052A1 (en) * 2016-03-02 2017-09-08 Patheon Austria Gmbh Co. & Kg Process and intermediates for the production of 17(20)-ene b-seco steroids
EP3962921B1 (en) * 2019-04-27 2025-11-05 Health Research, Inc. Coumarin-modified androgens for the treatment of prostate cancer
FI3805243T3 (fi) * 2019-10-09 2024-02-07 Windtree Therapeutics Inc Androstaanijohdannaisia, joilla on aktiivisuus puhtaina tai pääasiallisesti puhtaina SERCA2a:n stimulaattoreina, sydämen vajaatoiminnan hoitoon
CN111040012B (zh) * 2019-12-27 2022-04-15 山东安弘制药有限公司 一种依西美坦螺环氧乙烷杂质的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013009A (en) * 1959-04-10 1961-12-12 Searle & Co Optionally 17-alkylated and 7-oxygenated androst (an and 5-en)-3-ol aminoalkyl esters and ethers
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
EP0825197A2 (en) * 1996-08-19 1998-02-25 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
US3210386A (en) 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
DE1187236B (de) 1961-03-28 1965-02-18 Searle & Co Verfahren zur Herstellung von 17beta-Aminosteroiden
US3120515A (en) 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
US5522847A (en) * 1993-06-18 1996-06-04 Kalis; Amy G. Pacifier with novelty electronic display
US5662685A (en) * 1996-08-13 1997-09-02 Uhler; Gary S. Sound producing pacifier
US6066161A (en) * 1997-07-26 2000-05-23 Parella; Nicole D. X. Baby pacifier apparatus with remote control locator
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
DK1689410T3 (da) * 2003-11-26 2008-09-08 Bayer Schering Pharma Ag Forebyggelse og behandling af hypertensive hjertesygdomme ved de selektive östrogener 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol og 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013009A (en) * 1959-04-10 1961-12-12 Searle & Co Optionally 17-alkylated and 7-oxygenated androst (an and 5-en)-3-ol aminoalkyl esters and ethers
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
EP0825197A2 (en) * 1996-08-19 1998-02-25 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
TW200804406A (en) 2008-01-16
CA2649175A1 (en) 2007-10-25
US8609644B2 (en) 2013-12-17
AU2007239518B2 (en) 2012-03-15
PT2004668E (pt) 2013-04-30
US20110053902A1 (en) 2011-03-03
ES2405625T3 (es) 2013-05-31
JP2009533392A (ja) 2009-09-17
KR20080111532A (ko) 2008-12-23
CA2649175C (en) 2015-01-27
HK1134821A1 (en) 2010-05-14
EP2004668A2 (en) 2008-12-24
AR060427A1 (es) 2008-06-18
AU2007239518A2 (en) 2008-11-27
WO2007118832A2 (en) 2007-10-25
KR101424046B1 (ko) 2014-07-28
EA200870434A1 (ru) 2009-04-28
MX2008012942A (es) 2008-10-17
CN101466725B (zh) 2014-06-25
PL2004668T3 (pl) 2013-07-31
EA015257B1 (ru) 2011-06-30
BRPI0709943A2 (pt) 2011-08-02
CN101466725A (zh) 2009-06-24
EP2004668B1 (en) 2013-03-13
JP5438503B2 (ja) 2014-03-12
WO2007118832A3 (en) 2008-04-17
AU2007239518A1 (en) 2007-10-25

Similar Documents

Publication Publication Date Title
TWI392682B (zh) 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
JP5438502B2 (ja) 心臓脈管疾患のための医薬としてのアンドロスタンおよびアンドロステンのアザヘテロシクリル誘導体
JPH06192287A (ja) 心臓血管系に有効な１７−アリールおよび１７−ヘテロシクリル−１４β−５α−アンドロスタン、アンドロステン、およびアンドロスタジエン誘導体、これらの調製方法、およびこれらを含む医薬用組成物
EP2032593B1 (en) Amino derivatives of b-homoandrostanes and b-heteroandrostanes
JP3510651B2 (ja) 心臓血管系に作用する新規１７−ヒドロキシイミノメチル−５β，１４β−アンドロスタン誘導体
US8664210B2 (en) Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
HK1134821B (en) Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees