PL2004668T3 - Pochodne aminowe androstanów i androstenów jako leki do leczenia zaburzeń sercowo-naczyniowych - Google Patents

Pochodne aminowe androstanów i androstenów jako leki do leczenia zaburzeń sercowo-naczyniowych

Info

Publication number
PL2004668T3
PL2004668T3 PL07727992T PL07727992T PL2004668T3 PL 2004668 T3 PL2004668 T3 PL 2004668T3 PL 07727992 T PL07727992 T PL 07727992T PL 07727992 T PL07727992 T PL 07727992T PL 2004668 T3 PL2004668 T3 PL 2004668T3
Authority
PL
Poland
Prior art keywords
androstenes
androstanes
medicaments
cardiovascular disorders
amino derivatives
Prior art date
Application number
PL07727992T
Other languages
English (en)
Polish (pl)
Inventor
Alberto Cerri
Marco Torri
Silvia Armaroli
Leonardo Banfi
Giuseppe Bianchi
Giulio Carzana
Patrizia Ferrari
Rosamaria Micheletti
Simona Sputore
Maria Pia Zappavigna
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of PL2004668T3 publication Critical patent/PL2004668T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL07727992T 2006-04-13 2007-04-11 Pochodne aminowe androstanów i androstenów jako leki do leczenia zaburzeń sercowo-naczyniowych PL2004668T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06112598 2006-04-13
PCT/EP2007/053524 WO2007118832A2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
EP07727992A EP2004668B1 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Publications (1)

Publication Number Publication Date
PL2004668T3 true PL2004668T3 (pl) 2013-07-31

Family

ID=37268538

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07727992T PL2004668T3 (pl) 2006-04-13 2007-04-11 Pochodne aminowe androstanów i androstenów jako leki do leczenia zaburzeń sercowo-naczyniowych

Country Status (16)

Country Link
US (1) US8609644B2 (enExample)
EP (1) EP2004668B1 (enExample)
JP (1) JP5438503B2 (enExample)
KR (1) KR101424046B1 (enExample)
CN (1) CN101466725B (enExample)
AR (1) AR060427A1 (enExample)
AU (1) AU2007239518B2 (enExample)
BR (1) BRPI0709943A2 (enExample)
CA (1) CA2649175C (enExample)
EA (1) EA015257B1 (enExample)
ES (1) ES2405625T3 (enExample)
MX (1) MX2008012942A (enExample)
PL (1) PL2004668T3 (enExample)
PT (1) PT2004668E (enExample)
TW (1) TWI392682B (enExample)
WO (1) WO2007118832A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
JP5290189B2 (ja) * 2006-11-30 2013-09-18 エンディース エルエルシー ６−アルコキシアルキルエストラジオール誘導体およびその使用
JP5738267B2 (ja) * 2009-03-23 2015-06-24 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ タンパク尿、糸球体硬化、及び腎不全の治療に有用な５−β，１４−β−アンドロスタン誘導体
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
WO2017149052A1 (en) * 2016-03-02 2017-09-08 Patheon Austria Gmbh Co. & Kg Process and intermediates for the production of 17(20)-ene b-seco steroids
EP3962921B1 (en) * 2019-04-27 2025-11-05 Health Research, Inc. Coumarin-modified androgens for the treatment of prostate cancer
FI3805243T3 (fi) * 2019-10-09 2024-02-07 Windtree Therapeutics Inc Androstaanijohdannaisia, joilla on aktiivisuus puhtaina tai pääasiallisesti puhtaina SERCA2a:n stimulaattoreina, sydämen vajaatoiminnan hoitoon
CN111040012B (zh) * 2019-12-27 2022-04-15 山东安弘制药有限公司 一种依西美坦螺环氧乙烷杂质的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
BE589491A (enExample) * 1959-04-10
US3210386A (en) 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
DE1187236B (de) 1961-03-28 1965-02-18 Searle & Co Verfahren zur Herstellung von 17beta-Aminosteroiden
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US3120515A (en) 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
US5522847A (en) * 1993-06-18 1996-06-04 Kalis; Amy G. Pacifier with novelty electronic display
US5662685A (en) * 1996-08-13 1997-09-02 Uhler; Gary S. Sound producing pacifier
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
US6066161A (en) * 1997-07-26 2000-05-23 Parella; Nicole D. X. Baby pacifier apparatus with remote control locator
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
DK1689410T3 (da) * 2003-11-26 2008-09-08 Bayer Schering Pharma Ag Forebyggelse og behandling af hypertensive hjertesygdomme ved de selektive östrogener 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol og 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol

Also Published As

Publication number Publication date
TW200804406A (en) 2008-01-16
CA2649175A1 (en) 2007-10-25
US8609644B2 (en) 2013-12-17
AU2007239518B2 (en) 2012-03-15
PT2004668E (pt) 2013-04-30
US20110053902A1 (en) 2011-03-03
ES2405625T3 (es) 2013-05-31
JP2009533392A (ja) 2009-09-17
KR20080111532A (ko) 2008-12-23
TWI392682B (zh) 2013-04-11
CA2649175C (en) 2015-01-27
HK1134821A1 (en) 2010-05-14
EP2004668A2 (en) 2008-12-24
AR060427A1 (es) 2008-06-18
AU2007239518A2 (en) 2008-11-27
WO2007118832A2 (en) 2007-10-25
KR101424046B1 (ko) 2014-07-28
EA200870434A1 (ru) 2009-04-28
MX2008012942A (es) 2008-10-17
CN101466725B (zh) 2014-06-25
EA015257B1 (ru) 2011-06-30
BRPI0709943A2 (pt) 2011-08-02
CN101466725A (zh) 2009-06-24
EP2004668B1 (en) 2013-03-13
JP5438503B2 (ja) 2014-03-12
WO2007118832A3 (en) 2008-04-17
AU2007239518A1 (en) 2007-10-25

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