EA200870434A1 - Аминопроизводные андростанов и андростенов как лекарственные средства против сердечно-сосудистых нарушений - Google Patents

Аминопроизводные андростанов и андростенов как лекарственные средства против сердечно-сосудистых нарушений

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Publication number
EA200870434A1
EA200870434A1 EA200870434A EA200870434A EA200870434A1 EA 200870434 A1 EA200870434 A1 EA 200870434A1 EA 200870434 A EA200870434 A EA 200870434A EA 200870434 A EA200870434 A EA 200870434A EA 200870434 A1 EA200870434 A1 EA 200870434A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cardiovascular disorders
androstenov
androstanov
medicinal
compounds
Prior art date
Application number
EA200870434A
Other languages
English (en)
Other versions
EA015257B1 (ru
Inventor
Альберто Чеерри
Марко Торри
Сильвия Армароли
Леонардо Банфи
Джузеппе Бьянки
Джулио Карцана
Патриция Феррари
Розамария Микелетти
Симона Спуторе
Мария Пия Дзаппавинья
Original Assignee
Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. filed Critical Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Publication of EA200870434A1 publication Critical patent/EA200870434A1/ru
Publication of EA015257B1 publication Critical patent/EA015257B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Соединения формулы (I), где группы имеют значения, определенные в описании, можно использовать для получения лекарственных средств для лечения сердечно-сосудистых нарушений, в особенности сердечной недостаточности и гипертонии. Данные соединения являются ингибиторами ферментативной активности Na, K-АТФазы. Указанные соединения используют для для получения лекарственных средств для лечения заболевания, вызываемого гипертензивными эффектами эндогенного уабаина, такого как развитие почечной недостаточности при аутосомной доминантной поликистозной болезни почек (ADPKD), преэкламптическая гипертония и протеинурия и развитие почечной недостаточности у пациентов с полиморфизмом аддуцина.
EA200870434A 2006-04-13 2007-04-11 Аминопроизводные андростанов и андростенов как лекарственные средства против сердечно-сосудистых нарушений EA015257B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112598 2006-04-13
PCT/EP2007/053524 WO2007118832A2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Publications (2)

Publication Number Publication Date
EA200870434A1 true EA200870434A1 (ru) 2009-04-28
EA015257B1 EA015257B1 (ru) 2011-06-30

Family

ID=37268538

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870434A EA015257B1 (ru) 2006-04-13 2007-04-11 Аминопроизводные андростанов и андростенов как лекарственные средства против сердечно-сосудистых нарушений

Country Status (17)

Country Link
US (1) US8609644B2 (ru)
EP (1) EP2004668B1 (ru)
JP (1) JP5438503B2 (ru)
KR (1) KR101424046B1 (ru)
CN (1) CN101466725B (ru)
AR (1) AR060427A1 (ru)
AU (1) AU2007239518B2 (ru)
BR (1) BRPI0709943A2 (ru)
CA (1) CA2649175C (ru)
EA (1) EA015257B1 (ru)
ES (1) ES2405625T3 (ru)
HK (1) HK1134821A1 (ru)
MX (1) MX2008012942A (ru)
PL (1) PL2004668T3 (ru)
PT (1) PT2004668E (ru)
TW (1) TWI392682B (ru)
WO (1) WO2007118832A2 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
DK2099460T3 (da) * 2006-11-30 2017-01-02 Endece Llc 6-alkoxyalkylestradiolderivater og fremgangsmåder til anvendelse
KR101656797B1 (ko) * 2009-03-23 2016-09-12 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 단백뇨, 사구체경화증 및 신부전의 치료에 유용한 5-β, 14-β-안드로스탄 유도체
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20190047939A1 (en) * 2016-03-02 2019-02-14 Patheon Austria Gmbh & Co Kg Process and intermediates for the production of 17(20)-ene b-seco steroids
US20220218722A1 (en) * 2019-04-27 2022-07-14 Health Research, Inc. Coumarin-modified androgens for the treatment of prostate cancer
DK3805243T3 (da) * 2019-10-09 2024-01-02 Windtree Therapeutics Inc Androstanderivater med aktivitet som rene eller hovedsageligt rene stimulatorer af serca2a til behandling af hjertesvigt
CN111040012B (zh) * 2019-12-27 2022-04-15 山东安弘制药有限公司 一种依西美坦螺环氧乙烷杂质的制备方法

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GB868303A (en) * 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
NL104586C (ru) * 1959-04-10
US3210386A (en) 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
DE1187236B (de) 1961-03-28 1965-02-18 Searle & Co Verfahren zur Herstellung von 17beta-Aminosteroiden
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US3120515A (en) * 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
US5522847A (en) * 1993-06-18 1996-06-04 Kalis; Amy G. Pacifier with novelty electronic display
US5662685A (en) * 1996-08-13 1997-09-02 Uhler; Gary S. Sound producing pacifier
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
US6066161A (en) * 1997-07-26 2000-05-23 Parella; Nicole D. X. Baby pacifier apparatus with remote control locator
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
DE602004014020D1 (de) * 2003-11-26 2008-07-03 Bayer Schering Pharma Ag Prävention und behandlung von hypertonen herzerkrankungen mit den selektiven östrogenen 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol und 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol

Also Published As

Publication number Publication date
EP2004668B1 (en) 2013-03-13
US8609644B2 (en) 2013-12-17
AU2007239518A2 (en) 2008-11-27
PT2004668E (pt) 2013-04-30
US20110053902A1 (en) 2011-03-03
WO2007118832A3 (en) 2008-04-17
ES2405625T3 (es) 2013-05-31
BRPI0709943A2 (pt) 2011-08-02
HK1134821A1 (en) 2010-05-14
PL2004668T3 (pl) 2013-07-31
CN101466725B (zh) 2014-06-25
EP2004668A2 (en) 2008-12-24
MX2008012942A (es) 2008-10-17
EA015257B1 (ru) 2011-06-30
KR20080111532A (ko) 2008-12-23
AU2007239518A1 (en) 2007-10-25
TWI392682B (zh) 2013-04-11
AU2007239518B2 (en) 2012-03-15
JP2009533392A (ja) 2009-09-17
JP5438503B2 (ja) 2014-03-12
TW200804406A (en) 2008-01-16
CA2649175C (en) 2015-01-27
AR060427A1 (es) 2008-06-18
CN101466725A (zh) 2009-06-24
KR101424046B1 (ko) 2014-07-28
WO2007118832A2 (en) 2007-10-25
CA2649175A1 (en) 2007-10-25

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU