TWI367260B - Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof - Google Patents

Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof

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Publication number
TWI367260B
TWI367260B TW095109288A TW95109288A TWI367260B TW I367260 B TWI367260 B TW I367260B TW 095109288 A TW095109288 A TW 095109288A TW 95109288 A TW95109288 A TW 95109288A TW I367260 B TWI367260 B TW I367260B
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TW
Taiwan
Prior art keywords
trisomy
fetus
kit
detecting
pregnant woman
Prior art date
Application number
TW095109288A
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English (en)
Other versions
TW200643175A (en
Inventor
Yuk-Ming Lo
Wai Kwun Chiu
Siu Chung Chim
Bo Yin Tsui
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Univ Hong Kong Chinese
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Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of TW200643175A publication Critical patent/TW200643175A/zh
Application granted granted Critical
Publication of TWI367260B publication Critical patent/TWI367260B/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
TW095109288A 2005-03-18 2006-03-17 Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof TWI367260B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66329305P 2005-03-18 2005-03-18

Publications (2)

Publication Number Publication Date
TW200643175A TW200643175A (en) 2006-12-16
TWI367260B true TWI367260B (en) 2012-07-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW095109288A TWI367260B (en) 2005-03-18 2006-03-17 Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof

Country Status (9)

Country Link
US (4) US7718367B2 (zh)
EP (4) EP2612927B1 (zh)
JP (4) JP5629051B2 (zh)
CN (2) CN101137761B (zh)
AU (1) AU2006224973B9 (zh)
CA (4) CA3007182A1 (zh)
HK (4) HK1115169A1 (zh)
TW (1) TWI367260B (zh)
WO (1) WO2006097051A1 (zh)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI367260B (en) * 2005-03-18 2012-07-01 Univ Hong Kong Chinese Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US7888017B2 (en) * 2006-02-02 2011-02-15 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
JP5487555B2 (ja) * 2007-04-13 2014-05-07 国立大学法人 長崎大学 胎盤機能の網羅的かつ非侵襲的評価方法および検査用試薬
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
KR20230117256A (ko) * 2007-07-23 2023-08-07 더 차이니즈 유니버시티 오브 홍콩 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의진단 방법
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
ES2663662T3 (es) 2008-01-18 2018-04-16 President And Fellows Of Harvard College Métodos para detectar distintivos de enfermedades o afecciones en fluidos corporales
US8580503B2 (en) * 2008-01-27 2013-11-12 Rosetta Genomics Ltd. Methods and compositions for diagnosing complications of pregnancy
ES2389038T3 (es) * 2008-01-30 2012-10-22 Novartis Ag Enriquecimiento en dos etapas del ADN acelular en el plasma materno
WO2009105531A1 (en) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
WO2009146335A1 (en) * 2008-05-27 2009-12-03 Gene Security Network, Inc. Methods for embryo characterization and comparison
ES2620431T3 (es) * 2008-08-04 2017-06-28 Natera, Inc. Métodos para la determinación de alelos y de ploidía
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2952589B1 (en) 2008-09-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
PT2385992E (pt) * 2009-01-07 2015-04-16 Arcedi Biotech Aps Enriquecimento e identificação de células fetais em sangue materno e ligandos para esse uso
EP2854056A3 (en) 2009-09-30 2015-06-03 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
EP3660165B1 (en) 2009-12-22 2023-01-04 Sequenom, Inc. Processes and kits for identifying aneuploidy
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10179937B2 (en) 2014-04-21 2019-01-15 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
EP2854058A3 (en) 2010-05-18 2015-10-28 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
SG10201505723UA (en) 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
AU2011280936A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
CA2806310A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting diseases or conditions using phagocytic cells
US20130184178A1 (en) 2010-07-23 2013-07-18 President And Fellows Of Harvard College Methods of Detecting Autoimmune or Immune-Related Diseases or Conditions
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
ES2770342T3 (es) 2010-12-22 2020-07-01 Natera Inc Procedimientos para pruebas prenatales no invasivas de paternidad
CN102533960B (zh) 2010-12-31 2014-04-30 深圳华大基因科技有限公司 一种单细胞基因组分析方法及试剂盒
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
CN103608818B (zh) 2011-02-09 2017-12-08 纳特拉公司 非侵入性产前倍性识别装置
EP2702168B1 (en) 2011-04-29 2018-01-17 Sequenom, Inc. Quantification of a minority nucleic acid species
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
WO2013053359A1 (en) 2011-10-14 2013-04-18 Aarhus Universitet Diagnostic and prognostic use of prombp-complexes
US20150038358A1 (en) * 2011-12-01 2015-02-05 University Of Kansas Methods for detecting trisomy 21
US20210199673A1 (en) * 2011-12-01 2021-07-01 Carl Philip Weiner Combinations of biomarkers for methods for detecting trisomy 21
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013138527A1 (en) 2012-03-13 2013-09-19 The Chinese University Of Hong Kong Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis
WO2013169751A1 (en) * 2012-05-08 2013-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for providing a preeclampsia assessment
JP2015519900A (ja) 2012-05-21 2015-07-16 フリューダイム・コーポレイション 粒子集団の単粒子解析方法及び単粒子単離方法
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2013188686A2 (en) * 2012-06-15 2013-12-19 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome
AU2013290102B2 (en) 2012-07-13 2018-11-15 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
JP2015522293A (ja) 2012-07-19 2015-08-06 アリオサ ダイアグノスティックス インコーポレイテッドＡｒｉｏｓａ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． 多重化連続ライゲーションに基づく遺伝子変異体の検出
KR102241051B1 (ko) * 2013-02-28 2021-04-16 더 차이니즈 유니버시티 오브 홍콩 대량 동시 rna 서열분석에 의한 모체 혈장 전사물 분석
EP2965086A4 (en) 2013-03-09 2017-02-08 Harry Stylli Methods of detecting prostate cancer
US10494675B2 (en) 2013-03-09 2019-12-03 Cell Mdx, Llc Methods of detecting cancer
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
EP3024949B1 (en) * 2013-07-24 2019-03-06 The Chinese University Of Hong Kong B3gnt5 for use as a biomarker for premature birth
CN110283888B (zh) * 2013-08-19 2021-06-22 卓异生物公司 用于单分子检测的测定及其应用
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US9709556B2 (en) 2013-12-11 2017-07-18 Analiza, Inc. Devices and methods for determining and/or isolating circulating cancer cells
US20150160246A1 (en) 2013-12-11 2015-06-11 Analiza, Inc. Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells
CN103820565B (zh) * 2014-03-13 2016-02-03 上海融圆生物技术有限公司 21染色体中基因检测方法、相关检测探针组合物及检测试剂盒、以及相关应用
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
TWI564742B (zh) * 2014-08-22 2017-01-01 Methods for determining the aneuploidy of fetal chromosomes, systems and computer-readable media
US10626464B2 (en) 2014-09-11 2020-04-21 Cell Mdx, Llc Methods of detecting prostate cancer
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
CN113528623A (zh) * 2015-02-18 2021-10-22 卓异生物公司 用于单分子检测的测定及其应用
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
BE1022771B1 (nl) * 2015-10-14 2016-08-31 Multiplicom Nv Werkwijze en systeem om te bepalen of een vrouw zwanger is op basis van een bloedstaal
WO2017079741A1 (en) * 2015-11-05 2017-05-11 Wayne State University Kits and methods for prediction and treatment of preeclampsia
WO2017181367A1 (en) * 2016-04-20 2017-10-26 Ldx Prognostics Limited Co. Methods and compositions for prognosing preterm birth
WO2018056430A1 (ja) * 2016-09-23 2018-03-29 株式会社Ｄｎａチップ研究所 気分障害を検出する方法
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
CN109891239B (zh) * 2016-10-24 2022-04-05 苏州爱尔迪思生物科技有限公司 用于提供子痫前期评估和预测早产的方法和试剂盒
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CA3062226A1 (en) * 2018-05-25 2019-11-25 Illumina, Inc. Circulating rna signatures specific to preeclampsia
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
SG11202108405VA (en) 2019-02-14 2021-08-30 Mirvie Inc Methods and systems for determining a pregnancy-related state of a subject
CN114041053A (zh) 2019-06-07 2022-02-11 阿塞迪生物技术有限公司 使用facs分离胎儿细胞
CN110305954B (zh) * 2019-07-19 2022-10-04 广州市达瑞生物技术股份有限公司 一种早期准确检测先兆子痫的预测模型
CN110747276B (zh) * 2019-11-22 2020-06-30 山东大学齐鲁医院 Bace2作为胶质瘤预后/诊断/治疗标志物的应用
US11753685B2 (en) 2019-11-22 2023-09-12 Illumina, Inc. Circulating RNA signatures specific to preeclampsia
WO2022174000A2 (en) 2021-02-12 2022-08-18 Alnylam Pharmaceuticals, Inc. Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
WO2022197516A1 (en) * 2021-03-16 2022-09-22 Rosetta Signaling Laboratories, Llc Combinations of biomarkers for methods for detecting trisomy 21

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
CA2321223A1 (en) * 1998-02-25 1999-09-02 National University Of Ireland, Cork Hla linked pre-eclampsia and miscarriage susceptibility gene
CN1110573C (zh) * 1998-10-12 2003-06-04 韩健 检测人21号染色体三体的方法和试剂盒
FR2805824B1 (fr) * 2000-03-03 2002-05-03 Inst Nat Sante Rech Med Cultures de cytotrophoblastes de trisomie 21, et leur utilisation pour l'obtention de marqueurs de la trisomie 21
AU2001273318A1 (en) * 2000-07-07 2002-01-21 Genetics Institute, Llc Methods and compositions for diagnosing and treating preeclampsia and gestational trophoblast disorders
US6664056B2 (en) * 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
CA2818654A1 (en) * 2000-10-20 2002-04-25 Como Biotech Aps Pregnancy-associated plasma protein-a2 (papp-a2)
EP1368369A4 (en) 2000-11-15 2006-02-22 Hoffmann La Roche METHOD AND REAGENTS FOR IDENTIFYING RARE FOETAL CELLS IN THE MATERIAL CIRCUIT
JP2003259877A (ja) * 2002-03-11 2003-09-16 Sumitomo Pharmaceut Co Ltd 肝線維症疾患マーカーおよびその利用
JP2004187620A (ja) * 2002-12-13 2004-07-08 Sumitomo Pharmaceut Co Ltd 腎疾患の疾患マーカーおよびその利用
JP2004194534A (ja) * 2002-12-17 2004-07-15 Sumitomo Pharmaceut Co Ltd 炎症性腸疾患疾患マーカーおよびその利用
CA2513292C (en) * 2003-01-17 2016-04-05 The Chinese University Of Hong Kong Circulating mrna as diagnostic markers for pregnancy-related disorders
WO2005021793A1 (en) * 2003-08-29 2005-03-10 Pantarhei Bioscience B.V. Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
EP1524523A1 (en) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Use of ADAM 12 for diagnosis and therapy of preeclampsia
US20070054278A1 (en) * 2003-11-18 2007-03-08 Applera Corporation Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof
AU2005243064A1 (en) * 2004-05-19 2005-11-24 Harold Wood Hospital ADAM12, a novel marker for abnormal cell function
TWI367260B (en) * 2005-03-18 2012-07-01 Univ Hong Kong Chinese Method for detecting the presence of a fetus with trisomy 21 in a pregnant woman and kit thereof
US20080233583A1 (en) * 2007-02-20 2008-09-25 Regents Of The University Of California Biomarkers for preeclampsia
US20100016173A1 (en) * 2008-01-30 2010-01-21 Proteogenix, Inc. Maternal serum biomarkers for detection of pre-eclampsia

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AU2006224973A1 (en) 2006-09-21
HK1186756A1 (zh) 2014-03-21
EP2612927A2 (en) 2013-07-10
EP2612927B1 (en) 2016-02-03
EP2612927A3 (en) 2013-10-16
HK1115169A1 (en) 2008-11-21
WO2006097051A1 (en) 2006-09-21
CA2601735C (en) 2015-10-06
HK1142100A1 (zh) 2010-11-26
US20100267034A1 (en) 2010-10-21
US7718367B2 (en) 2010-05-18
CN101137761A (zh) 2008-03-05
US10731217B2 (en) 2020-08-04
JP2008524993A (ja) 2008-07-17
CA2894337C (en) 2018-08-28
US10006087B2 (en) 2018-06-26
JP5629051B2 (ja) 2014-11-19
CA3007182A1 (en) 2006-09-21
CN102010902A (zh) 2011-04-13
JP5800471B2 (ja) 2015-10-28
CA2894337A1 (en) 2006-09-21
HK1154407A1 (en) 2012-04-20
US20150284800A1 (en) 2015-10-08
US20060252068A1 (en) 2006-11-09
TW200643175A (en) 2006-12-16
EP2161347B1 (en) 2016-08-24
EP2161347A3 (en) 2010-06-16
JP2010213722A (ja) 2010-09-30
EP1859051A4 (en) 2009-08-05
EP2612928A3 (en) 2013-09-11
CA3147058A1 (en) 2006-09-21
JP2013150615A (ja) 2013-08-08
CA2601735A1 (en) 2006-09-21
EP1859051A1 (en) 2007-11-28
US20180327846A1 (en) 2018-11-15
AU2006224973B9 (en) 2010-02-11
JP2010268795A (ja) 2010-12-02
CN102010902B (zh) 2012-05-23
EP2612928A2 (en) 2013-07-10
AU2006224973B2 (en) 2009-10-29
CN101137761B (zh) 2010-12-08
EP2161347A2 (en) 2010-03-10

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