TWI356826B - - Google Patents

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Publication number
TWI356826B
TWI356826B TW094138512A TW94138512A TWI356826B TW I356826 B TWI356826 B TW I356826B TW 094138512 A TW094138512 A TW 094138512A TW 94138512 A TW94138512 A TW 94138512A TW I356826 B TWI356826 B TW I356826B
Authority
TW
Taiwan
Prior art keywords
cpm
allyl
group
pain
cyclopropylmethyl
Prior art date
Application number
TW094138512A
Other languages
English (en)
Chinese (zh)
Other versions
TW200621785A (en
Inventor
Naoki Izumimoto
Kuniaki Kawamura
Toshikazu Komagata
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of TW200621785A publication Critical patent/TW200621785A/zh
Application granted granted Critical
Publication of TWI356826B publication Critical patent/TWI356826B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW094138512A 2004-11-04 2005-11-03 Analgesic TW200621785A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004320583 2004-11-04

Publications (2)

Publication Number Publication Date
TW200621785A TW200621785A (en) 2006-07-01
TWI356826B true TWI356826B (https=) 2012-01-21

Family

ID=36319248

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094138512A TW200621785A (en) 2004-11-04 2005-11-03 Analgesic

Country Status (12)

Country Link
US (1) US8470845B2 (https=)
EP (1) EP1820505A4 (https=)
JP (1) JP4706636B2 (https=)
KR (1) KR101285645B1 (https=)
CN (1) CN101090722B (https=)
AR (1) AR053098A1 (https=)
CA (1) CA2586181C (https=)
MX (1) MX2007005336A (https=)
NO (1) NO20072832L (https=)
PE (1) PE20060723A1 (https=)
TW (1) TW200621785A (https=)
WO (1) WO2006049248A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2464593T3 (es) * 2005-11-09 2014-06-03 Toray Industries, Inc. Agente terapéutico o profiláctico para trastornos funcionales digestivos
CA2634055C (en) * 2005-12-21 2011-07-05 Toray Industries, Inc. Antitussive agent
FR2902341B1 (fr) 2006-06-16 2011-02-25 Scras Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
ES2627217T3 (es) * 2007-05-21 2017-07-27 Toray Industries, Inc. Partículas micropulverizadas cristalinas
AU2008254039B2 (en) * 2007-05-21 2013-10-24 Toray Industries, Inc. Method for producing pharmaceutical tablet
US9084817B2 (en) * 2007-05-21 2015-07-21 Toray Industries, Inc. Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation
FR2930447B1 (fr) 2008-04-25 2010-07-30 Sod Conseils Rech Applic Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
US20210015813A1 (en) 2018-03-08 2021-01-21 Victoria Link Ltd. Treatment of demyelinating diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118823B1 (https=) * 1964-02-03 1966-10-31
US3318885A (en) 1965-07-21 1967-05-09 American Cyanamid Co Substituted 6-amino-6, 14-endoethen-ocodides and morphides
NL8102558A (nl) * 1981-05-25 1982-12-16 Alcoa Nederland Bv Lichtmast met versterking van de opening in het onderste gedeelte.
KR970011390B1 (ko) * 1992-01-23 1997-07-10 도레이 가부시키가이샤 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물
AU686203B2 (en) 1993-07-23 1998-02-05 Toray Industries, Inc. Morphinan derivative and medicinal use
DE69631525T2 (de) 1995-03-03 2004-12-16 Endo Pharmaceuticals Inc. Verwendung von dextromethorphan oder dextrorphan zur behandlung der harninkontinenz
CN1374963A (zh) 1999-07-19 2002-10-16 东丽株式会社 尿频或尿失禁的治疗或预防剂
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
AU2002227135B2 (en) * 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
HK1079786B (zh) 2002-10-09 2010-03-12 东丽株式会社 尿频或尿失禁的治疗或预防剂以及具有含氮环状取代基的吗啡烷衍生物
JP4118824B2 (ja) 2004-02-24 2008-07-16 株式会社日立製作所 優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja) 2004-03-01 2008-07-16 リオン株式会社 補聴器用ケースなどの製造方法及びその装置
JP4882744B2 (ja) 2004-03-30 2012-02-22 東レ株式会社 止痒剤

Also Published As

Publication number Publication date
CA2586181A1 (en) 2006-05-11
JPWO2006049248A1 (ja) 2008-08-07
HK1115808A1 (en) 2008-12-12
JP4706636B2 (ja) 2011-06-22
AR053098A1 (es) 2007-04-25
TW200621785A (en) 2006-07-01
CA2586181C (en) 2012-11-27
US8470845B2 (en) 2013-06-25
PE20060723A1 (es) 2006-08-29
NO20072832L (no) 2007-08-01
EP1820505A4 (en) 2010-01-20
EP1820505A1 (en) 2007-08-22
MX2007005336A (es) 2007-06-25
KR20070085436A (ko) 2007-08-27
KR101285645B1 (ko) 2013-07-12
CN101090722B (zh) 2011-12-21
WO2006049248A1 (ja) 2006-05-11
CN101090722A (zh) 2007-12-19
US20070299100A1 (en) 2007-12-27

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees