PE20060723A1 - Derivados de morfina como agentes analgesicos - Google Patents
Derivados de morfina como agentes analgesicosInfo
- Publication number
- PE20060723A1 PE20060723A1 PE2005001291A PE2005001291A PE20060723A1 PE 20060723 A1 PE20060723 A1 PE 20060723A1 PE 2005001291 A PE2005001291 A PE 2005001291A PE 2005001291 A PE2005001291 A PE 2005001291A PE 20060723 A1 PE20060723 A1 PE 20060723A1
- Authority
- PE
- Peru
- Prior art keywords
- alcoxy
- morphinan
- ona
- cyclopropylmethyl
- dihydroxy
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004320583 | 2004-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060723A1 true PE20060723A1 (es) | 2006-08-29 |
Family
ID=36319248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001291A PE20060723A1 (es) | 2004-11-04 | 2005-11-03 | Derivados de morfina como agentes analgesicos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8470845B2 (https=) |
| EP (1) | EP1820505A4 (https=) |
| JP (1) | JP4706636B2 (https=) |
| KR (1) | KR101285645B1 (https=) |
| CN (1) | CN101090722B (https=) |
| AR (1) | AR053098A1 (https=) |
| CA (1) | CA2586181C (https=) |
| MX (1) | MX2007005336A (https=) |
| NO (1) | NO20072832L (https=) |
| PE (1) | PE20060723A1 (https=) |
| TW (1) | TW200621785A (https=) |
| WO (1) | WO2006049248A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2464593T3 (es) * | 2005-11-09 | 2014-06-03 | Toray Industries, Inc. | Agente terapéutico o profiláctico para trastornos funcionales digestivos |
| CA2634055C (en) * | 2005-12-21 | 2011-07-05 | Toray Industries, Inc. | Antitussive agent |
| FR2902341B1 (fr) | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
| ES2627217T3 (es) * | 2007-05-21 | 2017-07-27 | Toray Industries, Inc. | Partículas micropulverizadas cristalinas |
| AU2008254039B2 (en) * | 2007-05-21 | 2013-10-24 | Toray Industries, Inc. | Method for producing pharmaceutical tablet |
| US9084817B2 (en) * | 2007-05-21 | 2015-07-21 | Toray Industries, Inc. | Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation |
| FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
| US20210015813A1 (en) | 2018-03-08 | 2021-01-21 | Victoria Link Ltd. | Treatment of demyelinating diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4118823B1 (https=) * | 1964-02-03 | 1966-10-31 | ||
| US3318885A (en) | 1965-07-21 | 1967-05-09 | American Cyanamid Co | Substituted 6-amino-6, 14-endoethen-ocodides and morphides |
| NL8102558A (nl) * | 1981-05-25 | 1982-12-16 | Alcoa Nederland Bv | Lichtmast met versterking van de opening in het onderste gedeelte. |
| KR970011390B1 (ko) * | 1992-01-23 | 1997-07-10 | 도레이 가부시키가이샤 | 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물 |
| AU686203B2 (en) | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| DE69631525T2 (de) | 1995-03-03 | 2004-12-16 | Endo Pharmaceuticals Inc. | Verwendung von dextromethorphan oder dextrorphan zur behandlung der harninkontinenz |
| CN1374963A (zh) | 1999-07-19 | 2002-10-16 | 东丽株式会社 | 尿频或尿失禁的治疗或预防剂 |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| AU2002227135B2 (en) * | 2000-10-31 | 2008-01-03 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| HK1079786B (zh) | 2002-10-09 | 2010-03-12 | 东丽株式会社 | 尿频或尿失禁的治疗或预防剂以及具有含氮环状取代基的吗啡烷衍生物 |
| JP4118824B2 (ja) | 2004-02-24 | 2008-07-16 | 株式会社日立製作所 | 優先パケットの遅延を最小化するシェーピング装置 |
| JP4118826B2 (ja) | 2004-03-01 | 2008-07-16 | リオン株式会社 | 補聴器用ケースなどの製造方法及びその装置 |
| JP4882744B2 (ja) | 2004-03-30 | 2012-02-22 | 東レ株式会社 | 止痒剤 |
-
2005
- 2005-11-03 AR ARP050104603A patent/AR053098A1/es not_active Application Discontinuation
- 2005-11-03 PE PE2005001291A patent/PE20060723A1/es not_active Application Discontinuation
- 2005-11-03 TW TW094138512A patent/TW200621785A/zh not_active IP Right Cessation
- 2005-11-04 US US11/667,136 patent/US8470845B2/en not_active Expired - Fee Related
- 2005-11-04 CN CN200580045038XA patent/CN101090722B/zh not_active Expired - Fee Related
- 2005-11-04 KR KR1020077011752A patent/KR101285645B1/ko not_active Expired - Fee Related
- 2005-11-04 WO PCT/JP2005/020297 patent/WO2006049248A1/ja not_active Ceased
- 2005-11-04 CA CA2586181A patent/CA2586181C/en not_active Expired - Fee Related
- 2005-11-04 MX MX2007005336A patent/MX2007005336A/es active IP Right Grant
- 2005-11-04 JP JP2006542444A patent/JP4706636B2/ja not_active Expired - Fee Related
- 2005-11-04 EP EP05799891A patent/EP1820505A4/en not_active Withdrawn
-
2007
- 2007-06-04 NO NO20072832A patent/NO20072832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2586181A1 (en) | 2006-05-11 |
| JPWO2006049248A1 (ja) | 2008-08-07 |
| TWI356826B (https=) | 2012-01-21 |
| HK1115808A1 (en) | 2008-12-12 |
| JP4706636B2 (ja) | 2011-06-22 |
| AR053098A1 (es) | 2007-04-25 |
| TW200621785A (en) | 2006-07-01 |
| CA2586181C (en) | 2012-11-27 |
| US8470845B2 (en) | 2013-06-25 |
| NO20072832L (no) | 2007-08-01 |
| EP1820505A4 (en) | 2010-01-20 |
| EP1820505A1 (en) | 2007-08-22 |
| MX2007005336A (es) | 2007-06-25 |
| KR20070085436A (ko) | 2007-08-27 |
| KR101285645B1 (ko) | 2013-07-12 |
| CN101090722B (zh) | 2011-12-21 |
| WO2006049248A1 (ja) | 2006-05-11 |
| CN101090722A (zh) | 2007-12-19 |
| US20070299100A1 (en) | 2007-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |