PE20030497A1 - Combinaciones de un inhibidor de pde 5 y otros agentes activos - Google Patents

Combinaciones de un inhibidor de pde 5 y otros agentes activos

Info

Publication number
PE20030497A1
PE20030497A1 PE2002000949A PE2002000949A PE20030497A1 PE 20030497 A1 PE20030497 A1 PE 20030497A1 PE 2002000949 A PE2002000949 A PE 2002000949A PE 2002000949 A PE2002000949 A PE 2002000949A PE 20030497 A1 PE20030497 A1 PE 20030497A1
Authority
PE
Peru
Prior art keywords
inhibitors
alcoxy
alkyl
hydroxy
server
Prior art date
Application number
PE2002000949A
Other languages
English (en)
Inventor
David Saul Cohen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20030497A1 publication Critical patent/PE20030497A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMBINACION FARMACEUTICA QUE COMPRENDE UN INHIBIDOR DE PDE 5 DE FORMULA I DONDE R1 ES H, ALQUILO OPCIONALMENTE SUSTITUIDA POR HIDROXI, ALCOXI, ALQUILTIO; R2 ES H, ALQUILO, HIDROXIALQUILO, ALQUILCARBONILOXIALQUILO, ALCOXIALQUILO, ALQUILTIOALQUILO, ENTRE OTROS; R3 ES H, ALQUILO OPCIONALMENTE SUSTITUIDA POR HIDROXI, ALCOXI ALQUILTIO; R4 ES H, ALQUILO; R5 ES QUINOLILO, ISOQUINOLILO, OXODIHIDROISOQUINOLILO OPCIONALMENTE FUSIONADO A UN GRUPO HETEROCICLO DE 5 MIEMBROS; R6 Y R7 SON H, ALQUILO OPCIONALMENTE SUSTITUIDO POR HIDROXI, ALCOXI; DE PREFERENCIA 3-ISOBUTIL-8-(6-METOXI-ISOQUINOLIN-4-ILMETIL)-1-3,7-DIHIDRO-PURIN-2,6-DIONA; UN AGENTE ACTIVO SELECCIONADO DE UN AGENTE ANTIDIABETICO TAL COMO INSULINA; INHIBIDORES DE HMGCOA REDUCTASA TAL COMO ATORVASTATINA, CERIVASTATINA, FLUVASTATINA, ROSUVASTATINA, ENTRE OTROS, UN AGENTE ANTIHIPERTENSIVO TAL COMO INHIBIDORES DE ACE, BLOQUEADORES ADRENERGICOS, DIURETICOS, ENTRE OTROS, INHIBIDOR DE LA REABSORCION DE SEROTONINA SSRI TAL COMO FLUVOXAMINA, FLUOXETINA, PAROXETINA, SERTRALINA, ENTRE OTROS. LA COMBINACION PUEDE SER UTIL PARA LA PREVENCION O TRATAMIENTO DE DISFUNCION SEXUAL, HIPERGLICEMIA, HIPERINSULINEMIA, HIPERLIPIDEMIA, DIABETES, HIPERTRIGLICERIDEMIA, OBESIDAD, RETINOPATIA DIABETICA, GLOMERULOESCLEROSIS
PE2002000949A 2001-09-27 2002-09-26 Combinaciones de un inhibidor de pde 5 y otros agentes activos PE20030497A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32548501P 2001-09-27 2001-09-27

Publications (1)

Publication Number Publication Date
PE20030497A1 true PE20030497A1 (es) 2003-07-04

Family

ID=23268071

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000949A PE20030497A1 (es) 2001-09-27 2002-09-26 Combinaciones de un inhibidor de pde 5 y otros agentes activos

Country Status (12)

Country Link
US (1) US20030114469A1 (es)
EP (1) EP1432423A2 (es)
JP (1) JP2005504113A (es)
CN (1) CN1694707A (es)
AR (1) AR036584A1 (es)
AU (1) AU2002338806A1 (es)
BR (1) BR0212852A (es)
CA (1) CA2458343A1 (es)
MY (1) MY134639A (es)
PE (1) PE20030497A1 (es)
TW (1) TW200412970A (es)
WO (1) WO2003028730A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
DE10335027A1 (de) * 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
CA2516250A1 (en) 2003-02-19 2004-09-02 Endacea, Inc. A1 adenosine receptor antagonists
MXPA05009242A (es) * 2003-03-17 2006-04-18 Pfizer Prod Inc Tratamiento de la diabetes tipo 1 con los inhibidores de la pde5.
WO2004089416A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent
US7501405B2 (en) 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
JP2006528229A (ja) * 2003-05-22 2006-12-14 アルタナ　ファルマ　アクチエンゲゼルシャフト Ｐｄｅ４阻害剤及びｐｄｅ５阻害剤を含有する組成物
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
US20050054731A1 (en) * 2003-09-08 2005-03-10 Franco Folli Multi-system therapy for diabetes, the metabolic syndrome and obesity
WO2005041972A1 (en) * 2003-10-31 2005-05-12 Pfizer Products Inc. Phosphodiesterase 9 inhibition as treatment for obesity-related conditions
TW200605893A (en) * 2004-02-12 2006-02-16 Novartis Ag Use of organic compounds
EP1737465A4 (en) * 2004-04-19 2007-10-03 Univ Loma Linda COMPOSITION AND METHOD FOR REDUCING RENAL ISCHEMIC DAMAGE
CA2564517A1 (en) * 2004-05-08 2005-11-24 Neurogen Corporation 1-aryl-4-substituted isoquinolines
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
PT1814527E (pt) * 2004-11-05 2014-01-16 Boehringer Ingelheim Int Comprimido de bicamada compreendendo telmisartan e amlodipina
WO2006132091A1 (ja) * 2005-06-08 2006-12-14 Kowa Company, Ltd. 新規なトリグリセリド低下剤
EP1906934A4 (en) * 2005-07-14 2012-03-07 Franco Folli DAILY DOSAGE SCHEME FOR THE TREATMENT OF DIABETES, OBESITY, METABOLIC SYNDROME AND POLYKYSTIC OVAIRE SYNDROME
JP5330825B2 (ja) 2006-03-29 2013-10-30 興和株式会社 トリグリセリド低下剤及び高インスリン血症改善剤
ATE513831T1 (de) * 2006-04-21 2011-07-15 Pfizer Prod Inc Pyridinä3,4-büpyrazinone
ME01648B (me) 2006-07-05 2014-09-20 Nycomed Gmbh Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4,kao što je roflumilast, roflumilast-n-oksid za liječenje inflamatornih plućnih oboljenja
US8841300B2 (en) 2006-10-02 2014-09-23 Jerry M. Held Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor
WO2008144061A2 (en) * 2007-05-18 2008-11-27 Vivus, Inc. Novel combinations comprising a phosphodiesterase-5 inhibitor and their use
EP2266567A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
EP2266568A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
CN103476757A (zh) * 2011-02-18 2013-12-25 阿勒根公司 作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
HUE032613T2 (en) 2012-06-04 2017-10-30 Diamedica Therapeutics Inc Human tissue kallikrein 1 is glycosylated isoforms
WO2014071044A1 (en) * 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
EP3592377A4 (en) 2017-03-09 2021-02-17 Diamedica Inc. DOSAGE FORMS OF TISSUE KALLIKREIN 1
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

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Publication number Priority date Publication date Assignee Title
EP1037616B1 (en) * 1997-12-16 2006-03-01 Pfizer Products Inc. COMBINATION OF ALPHA-1-ADRENERGIC ANTAGONISTS AND A CGMP PDEv INHIBITOR FOR THE TREATMENT OF IMPOTENCE
DE19844162A1 (de) * 1998-09-25 2000-03-30 Udo Dunzendorfer Medikamentenkombinationen zur Therapie der erektilen Dysfunktion
US6087362A (en) * 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
HUP0300725A3 (en) * 2000-08-11 2005-11-28 Pfizer Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors
US6683080B2 (en) * 2001-02-02 2004-01-27 Pfizer Inc. Treatment of diabetes mellitus

Also Published As

Publication number Publication date
AR036584A1 (es) 2004-09-15
US20030114469A1 (en) 2003-06-19
WO2003028730A2 (en) 2003-04-10
TW200412970A (en) 2004-08-01
BR0212852A (pt) 2004-10-13
WO2003028730A3 (en) 2003-09-04
EP1432423A2 (en) 2004-06-30
JP2005504113A (ja) 2005-02-10
CA2458343A1 (en) 2003-04-10
CN1694707A (zh) 2005-11-09
AU2002338806A1 (en) 2003-04-14
MY134639A (en) 2007-12-31

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