PE20000428A1 - Nuevas dihidropirimidinas 2 heterociclicamente sustituidas - Google Patents
Nuevas dihidropirimidinas 2 heterociclicamente sustituidasInfo
- Publication number
- PE20000428A1 PE20000428A1 PE1999000310A PE00031099A PE20000428A1 PE 20000428 A1 PE20000428 A1 PE 20000428A1 PE 1999000310 A PE1999000310 A PE 1999000310A PE 00031099 A PE00031099 A PE 00031099A PE 20000428 A1 PE20000428 A1 PE 20000428A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- optionally substituted
- trifluoromethyl
- alkyl
- phenyl optionally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DIHIDROPIRIMIDINAS DE FORMULA I, DONDE R1 ES FENILO, FURILO, TIENILO, PIRIDILO, CICLOALQUILO C3-C6, ANILLO a, b, c OPCIONALMENTE SUSTITUIDOS CON HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, -S-R6, NR7R8, CO-NR9R10, SO2-CF3, -A-CH2-R11, ENTRE OTROS; R6 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO; R7, R8, R9 Y R10 SON H, FENILO OPCIONALMENTE SUSTITUIDO CON HIDROXI, ACILO C1-C6, ALQUILO C1-C6; A ES O, S, SO, SO2; R11 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, NITRO, TRIFLUOROMETILO, ENTRE OTROS; R2 ES -OR12, NR13R14; R12 ES H, ALCOXI C1-C6(CARBONILO), UN GRUPO HIDROCARBONADO C1-C8; R3 ES H, AMINO, -C-(OCH3)2-, FORMILO, CIANO, TRIFLUOROMETILO, UN RESTO HIDROCARBURO; R4 ES H, ALQUILO C1-C4, ACETILO, BENZOILO; D ES O o S; R5 ES H, HALOGENO, ALQUILO C1-C6. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I TIENE ACTIVIDAD ANTIVIRAL CONTRA EL VIRUS DE LA HEPATITIS B (HBV), POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO Y PROFILAXIS DE INFECCIONES CRONICAS Y AGUDAS POR HEPATITIS B
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19817262A DE19817262A1 (de) | 1998-04-18 | 1998-04-18 | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000428A1 true PE20000428A1 (es) | 2000-06-25 |
Family
ID=7864971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000310A PE20000428A1 (es) | 1998-04-18 | 1999-04-15 | Nuevas dihidropirimidinas 2 heterociclicamente sustituidas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6503913B1 (es) |
| EP (1) | EP1073653B1 (es) |
| JP (1) | JP2002512244A (es) |
| KR (1) | KR20010042787A (es) |
| CN (1) | CN1134434C (es) |
| AR (1) | AR015765A1 (es) |
| AU (1) | AU3420599A (es) |
| CA (1) | CA2328876A1 (es) |
| DE (2) | DE19817262A1 (es) |
| ES (1) | ES2181413T3 (es) |
| GT (1) | GT199900055A (es) |
| HK (1) | HK1037188A1 (es) |
| ID (1) | ID26308A (es) |
| PE (1) | PE20000428A1 (es) |
| SV (1) | SV1999000049A (es) |
| WO (1) | WO1999054329A1 (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000058302A1 (de) * | 1999-03-25 | 2000-10-05 | Bayer Aktiengesellschaft | Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b |
| EP1193259A4 (en) | 1999-06-23 | 2003-01-29 | Ajinomoto Kk | dihydropyrimidine |
| WO2001045712A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Arzneimittelkombinationen gegen virale erkrankungen |
| DE10012549A1 (de) * | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012824A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10013125A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| AU2007231012B2 (en) * | 2006-03-24 | 2013-07-04 | The Feinstein Institute For Medical Research | Phenolic hydrazone macrophage migration inhibitory factor inhibitors |
| CN101104617B (zh) * | 2006-07-10 | 2010-06-23 | 北京摩力克科技有限公司 | 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
| CN101104604B (zh) * | 2006-07-10 | 2011-03-02 | 北京摩力克科技有限公司 | 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
| CN100453542C (zh) * | 2007-04-30 | 2009-01-21 | 广东东阳光药业有限公司 | 2-杂环取代的二氢嘧啶消旋化合物的拆分方法 |
| PT2159224E (pt) | 2007-06-18 | 2012-10-24 | Sunshine Lake Pharma Co Ltd | Tiazolil dihidropirimidinas substituídas com bromo-fenilo |
| WO2008154820A1 (fr) * | 2007-06-18 | 2008-12-24 | Zhang, Zhongneng | Thiazolyl-dihydropyrimidines à substitution carbéthoxy |
| CN101328170B (zh) * | 2007-06-18 | 2011-09-14 | 张中能 | 一种氟苯基-取代噻唑二氢嘧啶 |
| WO2010069147A1 (zh) * | 2008-12-17 | 2010-06-24 | 张中能 | 二氢嘧啶类化合物、其组合物及其应用 |
| CN104302626B (zh) * | 2012-01-06 | 2016-09-07 | 爱尔兰詹森科学公司 | 4,4-二取代的-1,4-二氢嘧啶及其作为治疗乙型肝炎的药物的用途 |
| WO2013119895A1 (en) * | 2012-02-08 | 2013-08-15 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| RU2014142598A (ru) * | 2012-03-31 | 2016-05-27 | Ф. Хоффманн-Ля Рош Аг | Новые 4-метилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в |
| US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| CN104926808B (zh) | 2012-08-24 | 2018-09-14 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| CN103664925B (zh) * | 2012-09-07 | 2018-01-23 | 广东东阳光药业有限公司 | 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用 |
| CA2881322A1 (en) | 2012-09-10 | 2014-03-13 | F. Hoffmann-La Roche Ag | 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| AU2014352404B2 (en) | 2013-11-19 | 2018-07-19 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
| JP6434511B2 (ja) * | 2013-11-27 | 2018-12-05 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | ジヒドロピリミジン誘導体およびその中間体の製造方法 |
| US9771358B2 (en) | 2014-03-28 | 2017-09-26 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
| EP3253751B1 (en) | 2015-02-07 | 2020-12-09 | Sunshine Lake Pharma Co., Ltd. | Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2016183266A1 (en) | 2015-05-13 | 2016-11-17 | Enanta Pharmaceuticals, Inc. | Ehpatitis b antiviral agents |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| EP3353190B1 (en) | 2015-09-23 | 2021-03-17 | Reata Pharmaceuticals, Inc. | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
| CN108368113B (zh) * | 2015-11-04 | 2020-11-24 | 齐鲁制药有限公司 | 二氢吡啶并环化合物的晶型、制备方法和中间体 |
| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| ES2938341T3 (es) | 2016-03-07 | 2023-04-10 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis B |
| SG11201810834WA (en) * | 2016-06-10 | 2018-12-28 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| UA125519C2 (uk) | 2016-07-29 | 2022-04-13 | Суновіон Фармасьютікалз Інк. | Сполуки і композиції і їх застосування |
| SG11201900687VA (en) | 2016-07-29 | 2019-02-27 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| CA3070993A1 (en) | 2017-08-02 | 2019-02-07 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
| CN107501257B (zh) * | 2017-08-17 | 2020-05-29 | 山东大学 | 二氢嘧啶-三氮唑类衍生物及其制备方法与应用 |
| EA202090514A1 (ru) | 2017-08-28 | 2020-06-24 | Энанта Фармасьютикалс, Инк. | Противовирусное средство против гепатита в |
| CA3079557A1 (en) * | 2017-10-18 | 2019-04-25 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and uses thereof in medicine |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10865211B2 (en) | 2018-09-21 | 2020-12-15 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| KR20210093951A (ko) | 2018-11-21 | 2021-07-28 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스제로서의 작용화된 헤테로사이클 |
| AU2020236225A1 (en) | 2019-03-14 | 2021-09-16 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN112707910A (zh) * | 2019-10-24 | 2021-04-27 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| CN113512035B (zh) * | 2021-04-26 | 2023-11-24 | 山东大学 | 二氢嘧啶-泊马度胺缀合物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH550189A (de) | 1971-01-08 | 1974-06-14 | Ciba Geigy Ag | Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren. |
| CH569043A5 (es) | 1973-01-23 | 1975-11-14 | Ciba Geigy Ag | |
| DE3234684A1 (de) | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
-
1998
- 1998-04-18 DE DE19817262A patent/DE19817262A1/de not_active Withdrawn
-
1999
- 1999-04-07 US US09/673,597 patent/US6503913B1/en not_active Expired - Fee Related
- 1999-04-07 WO PCT/EP1999/002345 patent/WO1999054329A1/de not_active Application Discontinuation
- 1999-04-07 AU AU34205/99A patent/AU3420599A/en not_active Abandoned
- 1999-04-07 CN CNB998051705A patent/CN1134434C/zh not_active Expired - Fee Related
- 1999-04-07 KR KR1020007011526A patent/KR20010042787A/ko not_active Application Discontinuation
- 1999-04-07 JP JP2000544668A patent/JP2002512244A/ja active Pending
- 1999-04-07 ES ES99915743T patent/ES2181413T3/es not_active Expired - Lifetime
- 1999-04-07 ID IDW20002114A patent/ID26308A/id unknown
- 1999-04-07 CA CA002328876A patent/CA2328876A1/en not_active Abandoned
- 1999-04-07 EP EP99915743A patent/EP1073653B1/de not_active Expired - Lifetime
- 1999-04-07 DE DE59902470T patent/DE59902470D1/de not_active Expired - Fee Related
- 1999-04-15 AR ARP990101748A patent/AR015765A1/es unknown
- 1999-04-15 PE PE1999000310A patent/PE20000428A1/es not_active Application Discontinuation
- 1999-04-16 SV SV1999000049A patent/SV1999000049A/es unknown
- 1999-04-16 GT GT199900055A patent/GT199900055A/es unknown
-
2001
- 2001-11-16 HK HK01108100A patent/HK1037188A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE19817262A1 (de) | 1999-10-21 |
| WO1999054329A1 (de) | 1999-10-28 |
| DE59902470D1 (de) | 2002-10-02 |
| JP2002512244A (ja) | 2002-04-23 |
| EP1073653A1 (de) | 2001-02-07 |
| SV1999000049A (es) | 2000-07-04 |
| GT199900055A (es) | 2000-10-07 |
| CN1134434C (zh) | 2004-01-14 |
| CA2328876A1 (en) | 1999-10-28 |
| AR015765A1 (es) | 2001-05-16 |
| AU3420599A (en) | 1999-11-08 |
| KR20010042787A (ko) | 2001-05-25 |
| EP1073653B1 (de) | 2002-08-28 |
| HK1037188A1 (en) | 2002-02-01 |
| CN1297449A (zh) | 2001-05-30 |
| US6503913B1 (en) | 2003-01-07 |
| ID26308A (id) | 2000-12-14 |
| ES2181413T3 (es) | 2003-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |