TWI356701B - Compositions for affecting weight loss - Google Patents

Info

Publication number

TWI356701B

TWI356701B TW093111785A TW93111785A TWI356701B TW I356701 B TWI356701 B TW I356701B TW 093111785 A TW093111785 A TW 093111785A TW 93111785 A TW93111785 A TW 93111785A TW I356701 B TWI356701 B TW I356701B

Authority

TW

Taiwan

Prior art keywords

pharmaceutically acceptable

compound

acceptable salt

preferred

composition

Prior art date

2003-04-29

Links

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• 230000004580 weight loss Effects 0.000 title claims abstract description 37
• 150000001875 compounds Chemical class 0.000 claims abstract description 214
• 238000000034 method Methods 0.000 claims abstract description 98
• 230000000694 effects Effects 0.000 claims abstract description 66
• 239000003401 opiate antagonist Substances 0.000 claims abstract description 41
• 150000003839 salts Chemical class 0.000 claims description 67
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• 238000010791 quenching Methods 0.000 claims description 45
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• AGOFQOOAJAPLDU-UHFFFAOYSA-N sodium;1,3,5-triazine-2,4,6-triamine Chemical compound [Na].NC1=NC(N)=NC(N)=N1 AGOFQOOAJAPLDU-UHFFFAOYSA-N 0.000 claims description 23
• 229910052708 sodium Inorganic materials 0.000 claims description 21
• 239000011734 sodium Substances 0.000 claims description 21
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 20
• 239000000126 substance Substances 0.000 claims description 19
• SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 18
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• 239000003795 chemical substances by application Substances 0.000 claims description 14
• UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 11
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• AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 6
• ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 6
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