TWI354021B - Compositions and methods for inhibiting protein on - Google Patents
Compositions and methods for inhibiting protein on Download PDFInfo
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- TWI354021B TWI354021B TW92131215A TW92131215A TWI354021B TW I354021 B TWI354021 B TW I354021B TW 92131215 A TW92131215 A TW 92131215A TW 92131215 A TW92131215 A TW 92131215A TW I354021 B TWI354021 B TW I354021B
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- Prior art keywords
- solution
- polymer
- nipam
- lens
- contact lens
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 42
- 102000004169 proteins and genes Human genes 0.000 title claims description 38
- 108090000623 proteins and genes Proteins 0.000 title claims description 38
- 238000000034 method Methods 0.000 title claims description 22
- 230000002401 inhibitory effect Effects 0.000 title claims description 3
- 229920000642 polymer Polymers 0.000 claims description 80
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims description 52
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- 238000001179 sorption measurement Methods 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 8
- 229910052707 ruthenium Inorganic materials 0.000 claims description 8
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- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 5
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- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
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- NLAIHECABDOZBR-UHFFFAOYSA-M sodium 2,2-bis(2-methylprop-2-enoyloxymethyl)butyl 2-methylprop-2-enoate 2-hydroxyethyl 2-methylprop-2-enoate 2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O.CC(=C)C(=O)OCCO.CCC(COC(=O)C(C)=C)(COC(=O)C(C)=C)COC(=O)C(C)=C NLAIHECABDOZBR-UHFFFAOYSA-M 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
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- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
- A61L12/142—Polymeric biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3719—Polyamides or polyimides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
- C11D3/3773—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines in liquid compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Exhaust Silencers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43615902P | 2002-12-23 | 2002-12-23 |
Publications (2)
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| TW200413520A TW200413520A (en) | 2004-08-01 |
| TWI354021B true TWI354021B (en) | 2011-12-11 |
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| TW92131215A TWI354021B (en) | 2002-12-23 | 2003-11-07 | Compositions and methods for inhibiting protein on |
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| EP (2) | EP1575634B1 (enExample) |
| JP (1) | JP2006515685A (enExample) |
| KR (2) | KR20120059618A (enExample) |
| CN (1) | CN100346846C (enExample) |
| AR (1) | AR042633A1 (enExample) |
| AT (2) | ATE385813T1 (enExample) |
| AU (1) | AU2003296443B2 (enExample) |
| BR (1) | BR0317689A (enExample) |
| CA (1) | CA2508282C (enExample) |
| DE (2) | DE60334255D1 (enExample) |
| DK (1) | DK1938846T3 (enExample) |
| ES (3) | ES2298629T3 (enExample) |
| TW (1) | TWI354021B (enExample) |
| WO (1) | WO2004060429A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI354021B (en) | 2002-12-23 | 2011-12-11 | Alcon Inc | Compositions and methods for inhibiting protein on |
| CA2576971A1 (en) * | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| WO2008007790A1 (fr) * | 2006-07-14 | 2008-01-17 | Tomey Co., Ltd. | Agent liquide pour lentilles de contact et procédé pour hydrophiliser des lentilles de contact utilisant ledit agent |
| US7968650B2 (en) | 2006-10-31 | 2011-06-28 | Johnson & Johnson Vision Care, Inc. | Polymeric compositions comprising at least one volume excluding polymer |
| US20090171049A1 (en) * | 2007-12-27 | 2009-07-02 | Linhardt Jeffrey G | Segmented reactive block copolymers |
| US20090295004A1 (en) * | 2008-06-02 | 2009-12-03 | Pinsly Jeremy B | Silicone hydrogel contact lenses displaying reduced protein uptake |
| US8534031B2 (en) * | 2008-12-30 | 2013-09-17 | Bausch & Lomb Incorporated | Packaging solutions |
| US8240849B2 (en) * | 2009-03-31 | 2012-08-14 | Johnson & Johnson Vision Care, Inc. | Free form lens with refractive index variations |
| WO2014165582A1 (en) * | 2013-04-03 | 2014-10-09 | Southern Research Institute | Articles and methods related to transdermal delivery of a therapeutic agent |
| KR101599916B1 (ko) | 2014-06-10 | 2016-03-04 | 동신대학교산학협력단 | 콘택트 렌즈의 단백질 흡착을 방지하는 하이드로겔 콘택트 렌즈 및 이의 제조방법 |
| KR101671688B1 (ko) * | 2014-06-12 | 2016-11-03 | 충남대학교산학협력단 | 효소를 이용하여 pH를 조절하는 무세포 단백질 합성 방법 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452925A (en) * | 1981-02-09 | 1984-06-05 | National Patent Development Corporation | Biologically stabilized compositions comprising collagen as the minor component with ethylenically unsaturated compounds used as contact lenses |
| US4388428A (en) * | 1981-07-20 | 1983-06-14 | National Patent Development Corporation | Biologically stabilized compositions comprising collagen as the major component with ethylenically unsaturated compounds used as contact lenses |
| US4411932A (en) * | 1981-11-23 | 1983-10-25 | Alcon Laboratories, Inc. | Method for the prevention of soilant deposits on contact lenses |
| JPH0519213A (ja) * | 1991-07-10 | 1993-01-29 | Seiko Epson Corp | コンタクトレンズの製造方法 |
| JPH0580276A (ja) * | 1991-09-24 | 1993-04-02 | Seiko Epson Corp | コンタクトレンズ |
| JP3085480B2 (ja) * | 1991-10-02 | 2000-09-11 | セイコーエプソン株式会社 | ホルモン徐放性コンタクトレンズ |
| JPH05285164A (ja) * | 1992-04-03 | 1993-11-02 | Unitika Ltd | 抗血栓性眼内レンズ |
| JP3324156B2 (ja) * | 1992-10-12 | 2002-09-17 | セイコーエプソン株式会社 | コンタクトレンズ |
| KR970701739A (ko) * | 1994-03-04 | 1997-04-12 | 브라운 데이비드 피. | 블록 공중합체와 그라프트 공중합체 및 이들과 연관된 방법(Block and graft copolymers and methods relating thereto) |
| EP0851768B1 (en) * | 1995-09-01 | 2002-04-24 | University of Washington | Interactive molecular conjugates |
| KR0173089B1 (ko) * | 1996-01-30 | 1999-03-20 | 윤덕용 | N-이소프로필아크릴아미드/옥타데실아크릴레이트/아크릴산 공중합체로 피복된 방출온도 제어형 리포솜 및 그의 제조방법 |
| US6096138A (en) * | 1997-04-30 | 2000-08-01 | Bausch & Lomb Incorporated | Method for inhibiting the deposition of protein on contact lens |
| US6494861B1 (en) * | 1997-01-15 | 2002-12-17 | Boston Scientific Corporation | Drug delivery system |
| JPH10333103A (ja) * | 1997-05-28 | 1998-12-18 | Mitsuru Akashi | 生体適合性眼用レンズ及び生体適合性眼用レンズの製造方法 |
| US6153568A (en) * | 1997-11-12 | 2000-11-28 | Mccanna; David J. | Compositions comprising polyquaterniums in combination with polymeric biguanides for disinfecting contact lenses |
| ZA9811445B (en) | 1997-12-19 | 1999-08-16 | Alcon Lab Inc | Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions. |
| US6426086B1 (en) * | 1998-02-03 | 2002-07-30 | The Regents Of The University Of California | pH-sensitive, serum-stable liposomes |
| US5997961A (en) * | 1998-03-06 | 1999-12-07 | Battelle Memorial Institute | Method of bonding functional surface materials to substrates and applications in microtechnology and antifouling |
| US6447897B1 (en) * | 1998-03-06 | 2002-09-10 | Battelle Memorial Institute | Temperature sensitive surfaces and methods of making same |
| US6274133B1 (en) | 1998-12-22 | 2001-08-14 | Bausch & Lomb Incorporated | Method for treating extended-wear contact lenses in the eyes |
| WO2000056774A1 (en) * | 1999-03-19 | 2000-09-28 | Duke University | Methods of using bioelastomers |
| US6790816B2 (en) * | 1999-09-24 | 2004-09-14 | Bausch & Lomb Incorporated | High osmolyte cleaning and disinfection method and solution for contact lenses |
| JP2001256075A (ja) * | 2000-03-13 | 2001-09-21 | Nec Software Hokuriku Ltd | 開発システム、開発方法、記録媒体 |
| US6579519B2 (en) * | 2000-09-18 | 2003-06-17 | Registrar, University Of Delhi | Sustained release and long residing ophthalmic formulation and the process of preparing the same |
| AU1189402A (en) * | 2000-10-10 | 2002-04-22 | Genset Sa | Surface adsorbing polymers and the uses thereof to treat hydrophobic or hydrophilic surfaces |
| US20020155241A1 (en) | 2001-02-26 | 2002-10-24 | Tarasevich Barbara J. | Surface modifications of medical devices to reduce protein adsorption |
| JP3838882B2 (ja) * | 2001-02-28 | 2006-10-25 | 株式会社Ｐｈｇ | 温度応答性材料およびそれを含む組成物 |
| US6966322B2 (en) * | 2001-04-20 | 2005-11-22 | Medtronic, Inc. | Enhanced chronic lead removal |
| WO2003079985A2 (en) * | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
| US20060134050A1 (en) * | 2002-08-09 | 2006-06-22 | May Griffith | Bio-synthetic matrix and uses thereof |
| TWI354021B (en) | 2002-12-23 | 2011-12-11 | Alcon Inc | Compositions and methods for inhibiting protein on |
-
2003
- 2003-11-07 TW TW92131215A patent/TWI354021B/zh not_active IP Right Cessation
- 2003-12-11 KR KR1020127009256A patent/KR20120059618A/ko not_active Ceased
- 2003-12-11 WO PCT/US2003/039250 patent/WO2004060429A1/en not_active Ceased
- 2003-12-11 AT AT03814697T patent/ATE385813T1/de active
- 2003-12-11 CA CA2508282A patent/CA2508282C/en not_active Expired - Fee Related
- 2003-12-11 DE DE60334255T patent/DE60334255D1/de not_active Expired - Lifetime
- 2003-12-11 AT AT08002333T patent/ATE481117T1/de not_active IP Right Cessation
- 2003-12-11 ES ES03814697T patent/ES2298629T3/es not_active Expired - Lifetime
- 2003-12-11 EP EP20030814697 patent/EP1575634B1/en not_active Expired - Lifetime
- 2003-12-11 BR BR0317689A patent/BR0317689A/pt not_active IP Right Cessation
- 2003-12-11 DE DE2003619133 patent/DE60319133T2/de not_active Expired - Lifetime
- 2003-12-11 ES ES08002333T patent/ES2350378T3/es not_active Expired - Lifetime
- 2003-12-11 US US10/732,934 patent/US20040131870A1/en not_active Abandoned
- 2003-12-11 DK DK08002333T patent/DK1938846T3/da active
- 2003-12-11 JP JP2004565332A patent/JP2006515685A/ja not_active Withdrawn
- 2003-12-11 KR KR1020057011884A patent/KR20050086939A/ko not_active Ceased
- 2003-12-11 EP EP08002333A patent/EP1938846B1/en not_active Expired - Lifetime
- 2003-12-11 CN CNB2003801074303A patent/CN100346846C/zh not_active Expired - Fee Related
- 2003-12-11 AU AU2003296443A patent/AU2003296443B2/en not_active Ceased
- 2003-12-19 AR ARP030104753 patent/AR042633A1/es unknown
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2005
- 2005-11-15 US US11/273,778 patent/US7276552B2/en not_active Expired - Lifetime
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2007
- 2007-08-16 US US11/839,932 patent/US7468344B2/en not_active Expired - Lifetime
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2008
- 2008-05-27 US US12/127,050 patent/US7485607B2/en not_active Expired - Lifetime
- 2008-11-11 ES ES08019648T patent/ES2350379T3/es active Active
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| MM4A | Annulment or lapse of patent due to non-payment of fees |