TWI330528B - - Google Patents

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Publication number
TWI330528B
TWI330528B TW096100680A TW96100680A TWI330528B TW I330528 B TWI330528 B TW I330528B TW 096100680 A TW096100680 A TW 096100680A TW 96100680 A TW96100680 A TW 96100680A TW I330528 B TWI330528 B TW I330528B
Authority
TW
Taiwan
Prior art keywords
cells
compound
test
cell line
growth
Prior art date
Application number
TW096100680A
Other languages
English (en)
Chinese (zh)
Other versions
TW200829234A (en
Inventor
Sheng Yung Liu
Wu Che Wen
Original Assignee
Golden Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Golden Biotechnology Corp filed Critical Golden Biotechnology Corp
Priority to TW096100680A priority Critical patent/TW200829234A/zh
Priority to US11/747,407 priority patent/US7342137B1/en
Priority to DE102007022161A priority patent/DE102007022161A1/de
Priority to JP2007126866A priority patent/JP5085186B2/ja
Priority to GB0709171A priority patent/GB2445430A/en
Priority to KR1020070056701A priority patent/KR101011616B1/ko
Priority to FR0704175A priority patent/FR2911133A1/fr
Priority to ZA200800150A priority patent/ZA200800150B/en
Priority to NZ564913A priority patent/NZ564913A/en
Priority to NO20080078A priority patent/NO20080078L/no
Priority to SG200800098-6A priority patent/SG144815A1/en
Priority to AU2008200063A priority patent/AU2008200063C1/en
Priority to MYPI20080021A priority patent/MY144944A/en
Priority to CA2618271A priority patent/CA2618271C/en
Priority to BRPI0800401-3A priority patent/BRPI0800401A/pt
Priority to ARP080100073A priority patent/AR064788A1/es
Priority to PL08250090T priority patent/PL1942093T3/pl
Priority to SI200830296T priority patent/SI1942093T1/sl
Priority to ES08250090T priority patent/ES2365888T3/es
Priority to AT08250090T priority patent/ATE509005T1/de
Priority to PT08250090T priority patent/PT1942093E/pt
Priority to DK08250090.1T priority patent/DK1942093T5/da
Priority to EP08250090A priority patent/EP1942093B1/en
Publication of TW200829234A publication Critical patent/TW200829234A/zh
Application granted granted Critical
Publication of TWI330528B publication Critical patent/TWI330528B/zh
Priority to CY20111100713T priority patent/CY1111722T1/el
Priority to HR20110588T priority patent/HRP20110588T1/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fats And Perfumes (AREA)
TW096100680A 2007-01-08 2007-01-08 Antrodia camphorata isophorone extract TW200829234A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
TW096100680A TW200829234A (en) 2007-01-08 2007-01-08 Antrodia camphorata isophorone extract
US11/747,407 US7342137B1 (en) 2007-01-08 2007-05-11 Cyclohexenone compounds from Antrodia camphorata and application thereof
DE102007022161A DE102007022161A1 (de) 2007-01-08 2007-05-11 neue Cyclohexenonverbindungen aus Antrodia camphorata und deren Anwendung
JP2007126866A JP5085186B2 (ja) 2007-01-08 2007-05-11 ベニクスノキタケから単離された新規化合物
GB0709171A GB2445430A (en) 2007-01-08 2007-05-14 4-hydroxy-2,3-disubstituted-cyclohex-2-en-1-on-5-yl isoprenoids, extractable from Antrodia camphorata, as anti-tumour & cardiovascular agents, & antioxidant
KR1020070056701A KR101011616B1 (ko) 2007-01-08 2007-06-11 안트로디아 캄포라타로부터 얻은 신규 시클로헥세논 화합물및 그의 적용
FR0704175A FR2911133A1 (fr) 2007-01-08 2007-06-12 Nouveaux composes de cyclohexenone provenant d'antrodia camphorata et application de ceux-ci
ZA200800150A ZA200800150B (en) 2007-01-08 2008-01-01 Novel cyclohexenone compounds from antrodia camphorata and application thereof
NO20080078A NO20080078L (no) 2007-01-08 2008-01-04 Nye syklohexononforbindelser fra antrodia comphorata og anvendelser derav
NZ564913A NZ564913A (en) 2007-01-08 2008-01-04 Novel cyclohexenone compounds from antrodia camphorata and application thereof
MYPI20080021A MY144944A (en) 2007-01-08 2008-01-07 Novel cyclohexenone compounds from antrodia camphorata and application thereof
AU2008200063A AU2008200063C1 (en) 2007-01-08 2008-01-07 Novel cyclohexenone compounds from antrodia camphorata and application thereof
SG200800098-6A SG144815A1 (en) 2007-01-08 2008-01-07 Novel cyclohexenone compounds from antrodia camphorata and application thereof
CA2618271A CA2618271C (en) 2007-01-08 2008-01-07 Novel cyclohexenone compounds from antrodia camphorata and application thereof
ARP080100073A AR064788A1 (es) 2007-01-08 2008-01-08 Compuestos de ciclohexenona de la antrodia comphorata y usos de los mismos
BRPI0800401-3A BRPI0800401A (pt) 2007-01-08 2008-01-08 novos compostos da ciclohexenona a partir da antrodia camphorata e suas aplicações
SI200830296T SI1942093T1 (sl) 2007-01-08 2008-01-09 Nove cikloheksenonske spojine iz antrodia camphorata in njihove aplikacije
ES08250090T ES2365888T3 (es) 2007-01-08 2008-01-09 Compuestos de ciclohexenona novedosos procedentes de antrodia camphorata y sus aplicaciones.
PL08250090T PL1942093T3 (pl) 2007-01-08 2008-01-09 Nowe związki cykloheksenonowe z Antrodia camphorata oraz ich zastosowanie
AT08250090T ATE509005T1 (de) 2007-01-08 2008-01-09 Neuartige cyclohexenon-verbindungen aus antrodia camphorata und anwendungen dafür
PT08250090T PT1942093E (pt) 2007-01-08 2008-01-09 Novos compostos de cyclohexenone a partir de antrodia camphorata e sua aplicação
DK08250090.1T DK1942093T5 (da) 2007-01-08 2008-01-09 Hidtil ukendte cyclohexenon-forbindelser fra antrodia camphorata og anvendelse deraf
EP08250090A EP1942093B1 (en) 2007-01-08 2008-01-09 Novel cyclohexenone compounds from antrodia camphorata and application thereof
CY20111100713T CY1111722T1 (el) 2007-01-08 2011-07-20 Νεες ενωσεις κυκλοεξενονης απο antrodia camphorata και εφαρμογες αυτων
HR20110588T HRP20110588T1 (hr) 2007-01-08 2011-08-04 Novi cikloheksenonski spojevi iz antrodia camphorata i njihova primjena

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW096100680A TW200829234A (en) 2007-01-08 2007-01-08 Antrodia camphorata isophorone extract

Publications (2)

Publication Number Publication Date
TW200829234A TW200829234A (en) 2008-07-16
TWI330528B true TWI330528B (enExample) 2010-09-21

Family

ID=38219309

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096100680A TW200829234A (en) 2007-01-08 2007-01-08 Antrodia camphorata isophorone extract

Country Status (25)

Country Link
US (1) US7342137B1 (enExample)
EP (1) EP1942093B1 (enExample)
JP (1) JP5085186B2 (enExample)
KR (1) KR101011616B1 (enExample)
AR (1) AR064788A1 (enExample)
AT (1) ATE509005T1 (enExample)
AU (1) AU2008200063C1 (enExample)
BR (1) BRPI0800401A (enExample)
CA (1) CA2618271C (enExample)
CY (1) CY1111722T1 (enExample)
DE (1) DE102007022161A1 (enExample)
DK (1) DK1942093T5 (enExample)
ES (1) ES2365888T3 (enExample)
FR (1) FR2911133A1 (enExample)
GB (1) GB2445430A (enExample)
HR (1) HRP20110588T1 (enExample)
MY (1) MY144944A (enExample)
NO (1) NO20080078L (enExample)
NZ (1) NZ564913A (enExample)
PL (1) PL1942093T3 (enExample)
PT (1) PT1942093E (enExample)
SG (1) SG144815A1 (enExample)
SI (1) SI1942093T1 (enExample)
TW (1) TW200829234A (enExample)
ZA (1) ZA200800150B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI394572B (zh) * 2007-06-12 2013-05-01 Golden Biotechnology Corp Application of Cynanchum aurantii Cyclohexenone Compounds in the Preparation of Drugs for the Treatment of Autoimmune Diseases
TWI394573B (zh) * 2007-06-14 2013-05-01 國鼎生物科技股份有限公司 Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for Liver Protection
CN101333156B (zh) * 2007-06-27 2011-07-20 国鼎生物科技股份有限公司 牛樟芝环己烯酮化合物的制备方法及其应用
TWI394575B (zh) * 2007-07-09 2013-05-01 Golden Biotechnology Corp Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus
JP5203644B2 (ja) * 2007-07-13 2013-06-05 國鼎生物科技股▲ふん▼有限公司 自己免疫疾病の治療に用いるベニクスノキタケ由来の化合物
JP5106935B2 (ja) * 2007-07-17 2012-12-26 國鼎生物科技股▲ふん▼有限公司 生理的疲労の緩和に用いるベニクスノキタケのシクロヘキサンケトン化合物
CN101357883B (zh) * 2007-07-30 2012-09-26 国鼎生物科技股份有限公司 治疗自体免疫疾病的牛樟芝环己烯酮化合物及医药组成物
CN101362679B (zh) * 2007-08-08 2012-05-30 国鼎生物科技股份有限公司 用于抑制b型肝炎病毒的牛樟芝环己烯酮化合物
CN101376624B (zh) * 2007-08-29 2011-06-01 国鼎生物科技股份有限公司 用于护肝的牛樟芝环己烯酮化合物
CN101417934B (zh) * 2007-10-24 2012-04-18 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的化合物
TW201102076A (en) * 2009-07-09 2011-01-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea suppressing growth of tumor cell of osteosarcoma
TW201102075A (en) * 2009-07-09 2011-01-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of pancreatic cancer
TWI383790B (zh) * 2009-09-09 2013-02-01 國鼎生物科技股份有限公司 Used to inhibit the growth of oral cancer cells of the cattle Antrodylcyclohexenone compounds
TWI394566B (zh) * 2009-09-09 2013-05-01 國鼎生物科技股份有限公司 Used to inhibit the growth of ovarian cancer tumor cells of the cattle camphor cyclohexene ketone compounds
TW201109014A (en) * 2009-09-09 2011-03-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of skin cancer
TWI383791B (zh) * 2009-09-09 2013-02-01 國鼎生物科技股份有限公司 Used to inhibit the growth of gastric cancer tumor cells of the male antler ketone compounds
TW201109023A (en) * 2009-09-09 2011-03-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of colorectal cancer
TW201109024A (en) * 2009-09-09 2011-03-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of bladder cancer
TW201109013A (en) * 2009-09-09 2011-03-16 Golden Biotechnology Corp Cyclohexenone chemical compounds of Antrodia cinnamomea for suppressing the growth of the Lymphoma tumor cell
EP2329816B1 (en) 2009-11-26 2016-04-13 National Taiwan University An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
TWI452032B (zh) 2011-01-21 2014-09-11 國鼎生物科技股份有限公司 治療腎病之醫藥組成物
CN103796647A (zh) * 2011-06-10 2014-05-14 国鼎生物科技股份有限公司 用于治疗脑癌的方法和组合物
SE1350211A1 (sv) 2012-02-23 2013-08-24 Golden Biotechnology Corp Metoder och kompositioner för behandling av cancermetastaser
JP6234990B2 (ja) * 2012-03-26 2017-11-22 ゴールデン バイオテクノロジー コーポレーション 動脈硬化性血管疾患を処置するための方法及び組成物
KR102088078B1 (ko) * 2012-11-21 2020-03-12 골든 바이오테크놀러지 코포레이션 신경퇴행성 질환을 치료하기 위한 방법 및 조성물
CN103058846B (zh) * 2013-01-17 2014-07-30 福州大学 一种源于棘孢曲霉的苯醌衍生物及其应用
TWI612026B (zh) * 2013-02-20 2018-01-21 國鼎生物科技股份有限公司 環己烯酮組成物及其製造方法
US20150018296A1 (en) * 2013-03-15 2015-01-15 Golden Biotechnology Corporation Therapeutic methods and compositions utilizing cyclohexenone compounds
TWI583376B (zh) * 2013-03-20 2017-05-21 曾卉菱 Compounds isolated from Antelroxicus and their use
TW201521752A (zh) * 2013-12-05 2015-06-16 國立臺灣師範大學 牛樟芝於抗肥胖的應用及其方法
EP3082779B1 (en) * 2013-12-20 2023-06-07 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of type 2 mek and erk inhibitors
CN104522794B (zh) * 2014-12-04 2017-01-11 深圳市仁泰生物科技有限公司 樟芝解毒饮料及其制备方法
PL3240772T3 (pl) * 2014-12-30 2021-06-28 ONENESS BIOTECH CO., Ltd Związki z antrodia camphorata, sposoby ich otrzymywania i ich zastosowanie
TWI637746B (zh) * 2016-01-20 2018-10-11 台灣利得生物科技股份有限公司 固態培養牛樟芝菌絲體及子實體萃取物之組合物作為腫瘤抑制劑之應用

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JP5403844B2 (ja) * 2004-03-02 2014-01-29 善笙生物科技股▲分▼有限公司 AntrodiaCamphorataの菌糸体から得た新規な混合物及び化合物、並びにその使用
US7109232B2 (en) * 2004-03-08 2006-09-19 Simpson Biotech Co., Ltd. Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
TW200638867A (en) * 2005-05-06 2006-11-16 Golden Biotechnology Corp Incubation and application methods for the culture of antrodia camphorata
US20070116787A1 (en) * 2005-11-21 2007-05-24 Chih-Jung Yao Cancer treatment

Also Published As

Publication number Publication date
GB2445430A (en) 2008-07-09
AR064788A1 (es) 2009-04-22
TW200829234A (en) 2008-07-16
CY1111722T1 (el) 2015-10-07
US7342137B1 (en) 2008-03-11
GB0709171D0 (en) 2007-06-20
BRPI0800401A (pt) 2008-08-26
PT1942093E (pt) 2011-08-23
AU2008200063A1 (en) 2008-07-24
EP1942093A1 (en) 2008-07-09
EP1942093B1 (en) 2011-05-11
SG144815A1 (en) 2008-08-28
NZ564913A (en) 2009-05-31
JP5085186B2 (ja) 2012-11-28
NO20080078L (no) 2008-07-09
KR20080065218A (ko) 2008-07-11
DK1942093T5 (da) 2012-04-02
HRP20110588T1 (hr) 2011-11-30
ATE509005T1 (de) 2011-05-15
ES2365888T3 (es) 2011-10-13
SI1942093T1 (sl) 2012-01-31
AU2008200063B2 (en) 2010-01-07
PL1942093T3 (pl) 2011-10-31
AU2008200063C1 (en) 2011-05-19
CA2618271C (en) 2010-08-31
MY144944A (en) 2011-11-30
DE102007022161A1 (de) 2008-07-10
FR2911133A1 (fr) 2008-07-11
JP2008169194A (ja) 2008-07-24
KR101011616B1 (ko) 2011-01-27
CA2618271A1 (en) 2008-07-08
DK1942093T3 (da) 2011-08-29
ZA200800150B (en) 2009-08-26

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