TWI305724B - Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceutical - Google Patents

Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceutical Download PDF

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Publication number
TWI305724B
TWI305724B TW091119612A TW91119612A TWI305724B TW I305724 B TWI305724 B TW I305724B TW 091119612 A TW091119612 A TW 091119612A TW 91119612 A TW91119612 A TW 91119612A TW I305724 B TWI305724 B TW I305724B
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TW
Taiwan
Prior art keywords
alkyl
compound
patent application
treatment
scope
Prior art date
Application number
TW091119612A
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English (en)
Chinese (zh)
Inventor
Glombik Heiner
Falk Eugen
Frick Wendelin
Keil Stefanie
Schafer Hans-Ludwig
Schwink Lothar
Wendler Wolfgang
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10142734A external-priority patent/DE10142734A1/de
Priority claimed from DE2002123273 external-priority patent/DE10223273A1/de
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of TWI305724B publication Critical patent/TWI305724B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW091119612A 2001-08-31 2002-08-29 Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceutical TWI305724B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142734A DE10142734A1 (de) 2001-08-31 2001-08-31 Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2002123273 DE10223273A1 (de) 2002-05-24 2002-05-24 Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
TWI305724B true TWI305724B (en) 2009-02-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW091119612A TWI305724B (en) 2001-08-31 2002-08-29 Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceutical

Country Status (36)

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US (1) US6624185B2 (US20040106767A1-20040603-C00005.png)
EP (1) EP1425014B1 (US20040106767A1-20040603-C00005.png)
JP (1) JP4436129B2 (US20040106767A1-20040603-C00005.png)
KR (1) KR100915108B1 (US20040106767A1-20040603-C00005.png)
CN (1) CN1255103C (US20040106767A1-20040603-C00005.png)
AR (1) AR039063A1 (US20040106767A1-20040603-C00005.png)
AT (1) ATE347890T1 (US20040106767A1-20040603-C00005.png)
AU (1) AU2002333456B2 (US20040106767A1-20040603-C00005.png)
BG (1) BG108598A (US20040106767A1-20040603-C00005.png)
BR (1) BR0212158A (US20040106767A1-20040603-C00005.png)
CA (1) CA2458210C (US20040106767A1-20040603-C00005.png)
CO (1) CO5560562A2 (US20040106767A1-20040603-C00005.png)
CR (1) CR7261A (US20040106767A1-20040603-C00005.png)
CY (1) CY1106378T1 (US20040106767A1-20040603-C00005.png)
DE (1) DE50208960D1 (US20040106767A1-20040603-C00005.png)
DK (1) DK1425014T3 (US20040106767A1-20040603-C00005.png)
EE (1) EE05418B1 (US20040106767A1-20040603-C00005.png)
ES (1) ES2278077T3 (US20040106767A1-20040603-C00005.png)
HK (1) HK1067560A1 (US20040106767A1-20040603-C00005.png)
HR (1) HRP20040199A2 (US20040106767A1-20040603-C00005.png)
HU (1) HUP0401564A3 (US20040106767A1-20040603-C00005.png)
IL (2) IL160556A0 (US20040106767A1-20040603-C00005.png)
MA (1) MA27134A1 (US20040106767A1-20040603-C00005.png)
MX (1) MXPA04001850A (US20040106767A1-20040603-C00005.png)
MY (1) MY132789A (US20040106767A1-20040603-C00005.png)
NZ (1) NZ531440A (US20040106767A1-20040603-C00005.png)
OA (1) OA12656A (US20040106767A1-20040603-C00005.png)
PE (1) PE20030414A1 (US20040106767A1-20040603-C00005.png)
PL (1) PL208515B1 (US20040106767A1-20040603-C00005.png)
PT (1) PT1425014E (US20040106767A1-20040603-C00005.png)
RS (1) RS50889B (US20040106767A1-20040603-C00005.png)
RU (1) RU2330846C2 (US20040106767A1-20040603-C00005.png)
TN (1) TNSN04039A1 (US20040106767A1-20040603-C00005.png)
TW (1) TWI305724B (US20040106767A1-20040603-C00005.png)
UA (1) UA76773C2 (US20040106767A1-20040603-C00005.png)
WO (1) WO2003020269A1 (US20040106767A1-20040603-C00005.png)

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