TWI285118B - Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof - Google Patents
Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof Download PDFInfo
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- TWI285118B TWI285118B TW089112860A TW89112860A TWI285118B TW I285118 B TWI285118 B TW I285118B TW 089112860 A TW089112860 A TW 089112860A TW 89112860 A TW89112860 A TW 89112860A TW I285118 B TWI285118 B TW I285118B
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- 239000002552 dosage form Substances 0.000 title claims abstract description 17
- 150000003839 salts Chemical class 0.000 title claims abstract description 14
- 230000000147 hypnotic effect Effects 0.000 title claims abstract description 10
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- 238000004090 dissolution Methods 0.000 claims abstract description 30
- 239000003326 hypnotic agent Substances 0.000 claims abstract description 16
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 24
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- 229920001577 copolymer Polymers 0.000 claims description 19
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 18
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99401605A EP1064937A1 (en) | 1999-06-28 | 1999-06-28 | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI285118B true TWI285118B (en) | 2007-08-11 |
Family
ID=8242028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW089112860A TWI285118B (en) | 1999-06-28 | 2000-06-29 | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
Country Status (28)
| Country | Link |
|---|---|
| EP (2) | EP1064937A1 (enExample) |
| JP (1) | JP2003503340A (enExample) |
| KR (1) | KR20020015064A (enExample) |
| CN (1) | CN100415216C (enExample) |
| AR (1) | AR024491A1 (enExample) |
| AT (1) | ATE269062T1 (enExample) |
| AU (1) | AU782162B2 (enExample) |
| BR (1) | BR0011994A (enExample) |
| CA (1) | CA2370556C (enExample) |
| CO (1) | CO5190680A1 (enExample) |
| CZ (1) | CZ20014640A3 (enExample) |
| DE (1) | DE60011617T2 (enExample) |
| DK (1) | DK1194132T3 (enExample) |
| ES (1) | ES2222223T3 (enExample) |
| HK (1) | HK1043057B (enExample) |
| HU (1) | HU227810B1 (enExample) |
| IL (1) | IL146928A0 (enExample) |
| MX (1) | MXPA01013212A (enExample) |
| NO (1) | NO20016283L (enExample) |
| NZ (1) | NZ515997A (enExample) |
| PL (1) | PL201777B1 (enExample) |
| PT (1) | PT1194132E (enExample) |
| SI (1) | SI1194132T1 (enExample) |
| SK (1) | SK285347B6 (enExample) |
| TR (1) | TR200103594T2 (enExample) |
| TW (1) | TWI285118B (enExample) |
| WO (1) | WO2001000181A2 (enExample) |
| ZA (1) | ZA200110005B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
| US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| ATE241968T1 (de) * | 1999-08-26 | 2003-06-15 | Neurocrine Biosciences Inc | Sedativ hypnotische zusammensetzungen mit gesteuerter freisetzung und diesbezügliche verfahren |
| US7811557B1 (en) * | 2000-10-27 | 2010-10-12 | Viacell, Inc. | Methods for improving central nervous system functioning |
| WO2002083106A1 (en) * | 2001-04-05 | 2002-10-24 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
| WO2003004031A1 (en) | 2001-07-06 | 2003-01-16 | Endo Pharmaceuticals, Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
| DE60223254T2 (de) | 2001-07-06 | 2008-08-14 | Penwest Pharmaceuticals Co. | Verzögert freisetzende formulierungen von oxymorphon |
| AU2002354497A1 (en) * | 2001-12-19 | 2003-06-30 | Sanwa Kagaku Kenkyusho Co., Ltd | Release control type formed product |
| BR0306843A (pt) * | 2002-01-10 | 2004-12-07 | Biovail Lab Inc | Formulações sedativas de não-benzodiazepina |
| US20030165566A1 (en) * | 2002-01-10 | 2003-09-04 | O'toole Edel | Sedative non-benzodiazepine formulations |
| EP1941878A1 (en) * | 2002-01-10 | 2008-07-09 | Biovail Laboratories International Srl | Sedative non-benzodiazepine formulations |
| AU2003301762B2 (en) * | 2002-10-25 | 2006-02-09 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| JP4681843B2 (ja) * | 2004-09-30 | 2011-05-11 | 日本臓器製薬株式会社 | 固形医薬製剤 |
| GB0423964D0 (en) * | 2004-10-28 | 2004-12-01 | Jagotec Ag | Dosage form |
| FR2887455B1 (fr) * | 2005-06-28 | 2007-08-10 | Sanofi Aventis Sa | Formulation a liberation prolongee de principes actifs de medicaments |
| DE602006008339D1 (en) * | 2005-11-18 | 2009-09-17 | Synhton B V | Zolpidemtabletten |
| AR056633A1 (es) * | 2005-12-07 | 2007-10-17 | Gador Sa | Composiciones farmaceuticas de agentes hipnoticos de accion corta en forma de liberacion modificada y los procedimientos para preparar dichas formulaciones |
| US8309104B2 (en) * | 2006-03-02 | 2012-11-13 | Watson Pharmaceuticals, Inc. | Oral controlled release formulation for sedative and hypnotic agents |
| KR20070091960A (ko) * | 2006-03-08 | 2007-09-12 | 주식회사종근당 | 졸피뎀 또는 그의 염을 포함하는 안전한 제어방출형 제제조성물 |
| HUE029173T2 (hu) | 2006-04-26 | 2017-02-28 | Alphapharm Pty Ltd | Szabályozott hatóanyag-leadású készítmények, amelyek tartalmaznak nem bevont diszkrét egység(ek)et és egy késleltetett hatóanyag-leadású mátrixot |
| AU2013202441B2 (en) * | 2006-04-26 | 2016-02-25 | Alphapharm Pty Ltd | Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix |
| JP5275560B2 (ja) * | 2006-10-24 | 2013-08-28 | 小林化工株式会社 | 酒石酸ゾルピデム含有素錠の製造方法 |
| EP1938805A1 (en) * | 2006-12-22 | 2008-07-02 | LEK Pharmaceuticals D.D. | Monolithic sustained release zolpidem tablets |
| EP1970056A1 (en) * | 2007-03-15 | 2008-09-17 | Polichem S.A. | Time-specific delayed/pulsatile release dosage forms |
| WO2009021127A2 (en) * | 2007-08-07 | 2009-02-12 | Neurogen Corporation | Controlled released compositions |
| LT2276473T (lt) | 2008-04-18 | 2017-02-27 | Intec Pharma Ltd. | Pailginto atpalaidavimo vaistų karbidopa/levodopa įvedimas |
| US20100068278A1 (en) | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liablity Corporation Of The State Of Delaware | Ex vivo modifiable medicament release-associations |
| WO2010064139A2 (en) | 2008-12-04 | 2010-06-10 | Intec Pharma Ltd. | Zaleplon gastroretentive drug delivery system |
| RU2384336C1 (ru) * | 2009-04-22 | 2010-03-20 | Маргарита Алексеевна Морозова | Фармацевтический состав для коррекции психосоматических проявлений |
| CN102470108A (zh) * | 2009-07-07 | 2012-05-23 | 桑诺维恩药品公司 | 非pH依赖型制剂(6-(5-氯-2-吡啶基)-5-[(4-甲基-1-哌嗪基)羰氧基]-7-氧代-6，7-二氢-5H-吡咯并[3，4-b]吡嗪) |
| FR2949062B1 (fr) * | 2009-08-12 | 2011-09-02 | Debregeas Et Associes Pharma | Nouvelles formulations pharmaceutiques contre le mesusage des medicaments |
| GB201003766D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Pulsatile drug release |
| GB201003731D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Immediate/delayed drug delivery |
| GB201003734D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Delayed prolonged drug delivery |
| FR2968992B1 (fr) * | 2010-12-16 | 2013-02-08 | Sanofi Aventis | Comprime pharmaceutique orodispersible a base de zolpidem |
| FR2968995B1 (fr) * | 2010-12-16 | 2013-03-22 | Sanofi Aventis | Composition pharmaceutioue pour une administration par voie orale destinee a eviter le mesusage |
| TWI505841B (zh) * | 2011-09-29 | 2015-11-01 | Taiwan Biotech Co Ltd | 治療睡眠障礙之控釋調配物 |
| CA2934595C (en) * | 2014-02-06 | 2022-06-21 | Sequential Medicine Limited | Composition and method for aiding sleep |
| RU2659200C1 (ru) * | 2017-07-24 | 2018-06-28 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Фармацевтический состав, содержащий алимемазина тартрат |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8404467D0 (sv) * | 1984-09-06 | 1984-09-06 | Ferrosan Ab | Controlled-release medical preparations |
| GB2185887B (en) * | 1987-02-18 | 1989-12-06 | Farmitalia Carlo Erba Ltd | Temazepam composition |
| ATE107854T1 (de) * | 1988-09-30 | 1994-07-15 | Rhone Poulenc Rorer Ltd | Pharmazeutisches granulat. |
| FR2656303B1 (fr) * | 1989-12-26 | 1994-06-10 | Parke Davis | Solution buvable d'un derive des benzodiazepines et son application pharmacologique. |
| IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
| IT1264517B1 (it) * | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
| IT1276689B1 (it) * | 1995-06-09 | 1997-11-03 | Applied Pharma Res | Forma farmaceutica solida ad uso orale |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| FR2742660B1 (fr) * | 1995-12-22 | 1998-04-03 | Ethypharm Lab Prod Ethiques | Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif |
| HRP970493A2 (en) * | 1996-09-23 | 1998-08-31 | Wienman E. Phlips | Oral delayed immediate release medical formulation and method for preparing the same |
| BR9802915A (pt) * | 1997-09-12 | 2000-01-11 | Oscar Gold | Procedimento para formar composições farmaceuticas em pilulas ou granulos substancialmente esfericos, de ação controlada e continuada, contendo como agente ativo o (7-bromo-1,3-diidro-5-(2-piridninilo)-2h-1,4-benzodiazep ina-2(1h)-um) |
| US6066339A (en) * | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
| FR2772615B1 (fr) * | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
| EP1005863A1 (en) * | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
-
1999
- 1999-06-28 EP EP99401605A patent/EP1064937A1/en not_active Withdrawn
-
2000
- 2000-06-27 KR KR1020017016730A patent/KR20020015064A/ko not_active Ceased
- 2000-06-27 NZ NZ515997A patent/NZ515997A/xx not_active IP Right Cessation
- 2000-06-27 MX MXPA01013212A patent/MXPA01013212A/es active IP Right Grant
- 2000-06-27 CN CNB00809487XA patent/CN100415216C/zh not_active Expired - Fee Related
- 2000-06-27 WO PCT/EP2000/006792 patent/WO2001000181A2/en not_active Ceased
- 2000-06-27 ES ES00954518T patent/ES2222223T3/es not_active Expired - Lifetime
- 2000-06-27 HU HU0201907A patent/HU227810B1/hu not_active IP Right Cessation
- 2000-06-27 JP JP2001505891A patent/JP2003503340A/ja active Pending
- 2000-06-27 TR TR2001/03594T patent/TR200103594T2/xx unknown
- 2000-06-27 SI SI200030461T patent/SI1194132T1/xx unknown
- 2000-06-27 SK SK1911-2001A patent/SK285347B6/sk not_active IP Right Cessation
- 2000-06-27 DE DE60011617T patent/DE60011617T2/de not_active Expired - Lifetime
- 2000-06-27 BR BR0011994-6A patent/BR0011994A/pt not_active Application Discontinuation
- 2000-06-27 CZ CZ20014640A patent/CZ20014640A3/cs unknown
- 2000-06-27 PT PT00954518T patent/PT1194132E/pt unknown
- 2000-06-27 AT AT00954518T patent/ATE269062T1/de active
- 2000-06-27 EP EP00954518A patent/EP1194132B1/en not_active Expired - Lifetime
- 2000-06-27 HK HK02104684.1A patent/HK1043057B/en not_active IP Right Cessation
- 2000-06-27 AU AU66944/00A patent/AU782162B2/en not_active Ceased
- 2000-06-27 AR ARP000103214A patent/AR024491A1/es unknown
- 2000-06-27 IL IL14692800A patent/IL146928A0/xx not_active IP Right Cessation
- 2000-06-27 DK DK00954518T patent/DK1194132T3/da active
- 2000-06-27 CO CO00048052A patent/CO5190680A1/es active IP Right Grant
- 2000-06-27 PL PL357348A patent/PL201777B1/pl unknown
- 2000-06-27 CA CA002370556A patent/CA2370556C/en not_active Expired - Fee Related
- 2000-06-29 TW TW089112860A patent/TWI285118B/zh not_active IP Right Cessation
-
2001
- 2001-12-05 ZA ZA200110005A patent/ZA200110005B/xx unknown
- 2001-12-20 NO NO20016283A patent/NO20016283L/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |