TWI254725B - Process for the production of sheet-like administration forms - Google Patents

Process for the production of sheet-like administration forms Download PDF

Info

Publication number
TWI254725B
TWI254725B TW089101364A TW89101364A TWI254725B TW I254725 B TWI254725 B TW I254725B TW 089101364 A TW089101364 A TW 089101364A TW 89101364 A TW89101364 A TW 89101364A TW I254725 B TWI254725 B TW I254725B
Authority
TW
Taiwan
Prior art keywords
drying
sheet
product
application
flaky
Prior art date
Application number
TW089101364A
Other languages
English (en)
Inventor
Michael Horstmann
Wolfgang Laux
Horst Dzekan
Katia Zinndorf
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Application granted granted Critical
Publication of TWI254725B publication Critical patent/TWI254725B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/79—Fixation, conservation, or encapsulation of flavouring agents in the form of films
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Description

1254725 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（v ) ，來增加張力強度。爲了調節表面的黏著性，可衡量使用 例如:矽化、氟化、酸處理或電暈處理，但是在每一個各別 情形下’這些需要澄淸其對相關使用目的之生理承受度。 如果塗覆團塊所面對的表面不具有平滑的外形，但是 外形不鋒利，並且在任何情況下是粗糙表面的外形時，根 據本發明可達到特別的優點。尖峰對凹谷的高度是在〇·1 微米至約10微米的範圍、較佳爲0.5及3微米之間。其優 點是在微結構中爲圓隆的突出物，其進一步減少滑動磨擦 〇 本發明的目的是要經常性地達到:其中乾燥的發生是在 引發升溫的加工溫度下，並且然後在最後區域、最終時間 下降10°C。有利地，可調整製程速率，使得能得到具有相 當於濕度爲50-75%相對濕度、較佳爲60-68%相對濕度的 產品。在得到產品的這些製程條件下，證明表面穩定、有 彈性、且抗斷裂、並大大地抗撕裂。所得的表面顯示實際 上沒有”冷流(cold flow)”，並且因此基本上是方向性穩定的 。該薄膜可自支撐物上移除，而沒有可察覺到的拉長發生 ，並且可進一步分別加工。 均等空氣濕度的測量如下:面積約〇·1平方公尺之新製 造的產品片，使用橡膠手套’立刻且快速地被折疊，並且 置於一個廣口玻璃容器中’其蓋子提供一個開孔’使得濕 度計的測量頭被導入其中。約一^分is之後’視裝置的構造 而定，讀取測量値。 在縱向之後進行進一步的加工:在裝置上打洞，或簡易 8 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -------------------訂，--------- (請先閲讀背面之注意事項再填寫本頁) 1254725 A7 _B7_ 五、發明說明（"(） 地在橫向上進行。所產生的片狀產品較佳地具有厚度在20 及300微米之間；其大小可有利地從0.5至12平方公分。 後續的包裝可單獨或成疊的進行，舉例而言:以封裝的小袋 或劑量分裝。 -------------------訂；-------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 9 本紙張尺度適用中國國家標準（CNS)A4規格mo X 297公釐）

Claims (1)

  1. A8 B8 C8 D8 ^2Si47£5 、申請專利範圍 1·一種製造薄片狀施用形式的方法，其係經由於基質 上塗覆並且乾燥含溶劑之可伸展團塊，其特徵在於乾燥之 進行，在第一個乾燥階段是在30及50°C之間，在第二個 乾燥階段是在稍微升高之35及8CTC之間的溫度，並且最 後接著的重調節階段是在25及50°C之間，以及，將相對 基質濕度維持在50-75%相對濕度。 2·根據申請專利範圍第1項的方法，其特徵在於使相 對基質濕度維持在6 0 - 6 8 %相對濕度。 3·根據申請專利範圍第1項的方法，其特徵在於該積 層品乾燥之進行，在乾燥階段的第一個時間的三分之一是在 3〇及5〇°C之間，在第二個三分之一是在35及8(rc之間，並 且最後三分之一是在25及5〇°c之間。 4·根據申請專利範圍第1項的方法，其特徵在於該薄 片狀產品的乾燥是在一個具有粗糙表面的物質上進行。 5.根據申請專利範圍第4項的方法，其特徵在於有聚 乙烯塗覆的紙張被使用作爲具有粗糙表面的物質。 6·根據申g靑專利範圍第1至5項中任一項的方法，其 特徵在於該薄片狀產品包含風味劑/、 ^ ^ 7·根據申g轉翻醜1至5項中任—糊方法，其 k徵在於s請片狀產品包含黏稠性多糖(p.㈣以作爲本 要成份。 ~ 8·根據申請專·圍第1彡5項中任-_方法，I 特徵在於_片狀產品包含_主要成份之_性多糖 (pullulan)，以及風味劑。 本紙張尺度適財關家標準(CNS) A4規格(210 X 297^Jy (請先閲讀背面之注意事項再塡寫本頁)
TW089101364A 1999-02-12 2000-01-27 Process for the production of sheet-like administration forms TWI254725B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19905801A DE19905801B4 (de) 1999-02-12 1999-02-12 Verfahren zur Herstellung folienförmiger Darreichungsformen

Publications (1)

Publication Number Publication Date
TWI254725B true TWI254725B (en) 2006-05-11

Family

ID=7897244

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089101364A TWI254725B (en) 1999-02-12 2000-01-27 Process for the production of sheet-like administration forms

Country Status (22)

Country Link
EP (1) EP1150663A2 (zh)
JP (1) JP2002536402A (zh)
KR (1) KR100620068B1 (zh)
CN (1) CN1147293C (zh)
AR (1) AR022580A1 (zh)
AU (1) AU777898B2 (zh)
BR (1) BR0009962B1 (zh)
CA (1) CA2362756C (zh)
CZ (1) CZ301872B6 (zh)
DE (1) DE19905801B4 (zh)
HK (1) HK1039069A1 (zh)
HU (1) HUP0202877A2 (zh)
IL (2) IL144767A0 (zh)
MX (1) MXPA01007867A (zh)
NO (1) NO20013892L (zh)
NZ (1) NZ513465A (zh)
PL (1) PL202678B1 (zh)
RU (1) RU2226389C2 (zh)
TR (1) TR200102056T2 (zh)
TW (1) TWI254725B (zh)
WO (1) WO2000047190A2 (zh)
ZA (1) ZA200106580B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10114509A1 (de) * 2001-03-23 2002-10-02 Haarmann & Reimer Gmbh Verfahren zur Herstellung von Einkapselungen
ES2294180T3 (es) 2001-12-11 2008-04-01 Ceapro Inc. Composiciones de beta-glucano de cereales, metodos de preparacion y usos de las mismas.
JP5860480B2 (ja) 2011-01-11 2016-02-16 キャプシュゲル・ベルジウム・エヌ・ヴィ プルランを含む新しい硬カプセル
EP3610028A1 (en) 2017-04-14 2020-02-19 Capsugel Belgium NV Process for making pullulan
US11576870B2 (en) 2017-04-14 2023-02-14 Capsugel Belgium Nv Pullulan capsules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6055039A (ja) * 1983-09-07 1985-03-29 Mitsubishi Acetate Co Ltd 水溶性多糖類フイルム
DE3333240A1 (de) * 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
JPH0744940B2 (ja) * 1986-12-24 1995-05-17 ライオン株式会社 口腔貼付用基材
DE3827561C1 (zh) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5656297A (en) * 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
DE19652257A1 (de) * 1996-12-16 1998-06-18 Lohmann Therapie Syst Lts Einzeln dosierte, bei Kontakt mit Flüssigkeit schnell zerfallende, wirkstoff- und insbesondere aromastoffhaltige, folienförmige Darreichnungsform

Also Published As

Publication number Publication date
DE19905801B4 (de) 2008-03-13
CZ20012900A3 (cs) 2002-01-16
IL144767A (en) 2006-08-20
EP1150663A2 (de) 2001-11-07
NO20013892D0 (no) 2001-08-09
AU777898B2 (en) 2004-11-04
CA2362756A1 (en) 2000-08-17
MXPA01007867A (es) 2002-07-02
AR022580A1 (es) 2002-09-04
WO2000047190A3 (de) 2000-12-14
PL349857A1 (en) 2002-09-23
CN1147293C (zh) 2004-04-28
BR0009962A (pt) 2002-04-16
NZ513465A (en) 2003-05-30
ZA200106580B (en) 2002-02-14
KR20010102050A (ko) 2001-11-15
TR200102056T2 (tr) 2001-11-21
JP2002536402A (ja) 2002-10-29
KR100620068B1 (ko) 2006-09-05
WO2000047190A2 (de) 2000-08-17
CA2362756C (en) 2009-11-24
CN1336820A (zh) 2002-02-20
RU2226389C2 (ru) 2004-04-10
HK1039069A1 (zh) 2002-04-12
DE19905801A1 (de) 2000-08-17
BR0009962B1 (pt) 2014-07-29
NO20013892L (no) 2001-08-09
PL202678B1 (pl) 2009-07-31
CZ301872B6 (cs) 2010-07-14
IL144767A0 (en) 2002-06-30
AU3151400A (en) 2000-08-29
HUP0202877A2 (hu) 2003-03-28

Similar Documents

Publication Publication Date Title
Jonker et al. Intestinal paracellular permeation enhancement with quaternised chitosan: in situ and in vitro evaluation
Visser et al. Orodispersible films in individualized pharmacotherapy: The development of a formulation for pharmacy preparations
Kotzé et al. Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
TWI254725B (en) Process for the production of sheet-like administration forms
TWI276526B (en) Method for producing acylated cellulose film
TW384261B (en) Pad including adhesively adhered sheets
BR0108470A (pt) Conjunto de pré-misturas fluìdas diferentes porém mutuamente compatìveis, adesivo, e, processos de formação de pelo menos um revestimento adesivo, de formação de uma série de adesivos e de formação de pelo menos um revestimento de calafeto
Cleary et al. Adhesion of polyether-modified poly (acrylic acid) to mucin
Lee et al. A janus mucoadhesive and omniphobic device for gastrointestinal retention
US10488108B2 (en) Indirect acoustic drying system and method
Jindal et al. An insight into the properties of Aegle marmelos pectin–chitosan cross-linked films
US3865342A (en) Support for frame, plaque, or the like
Wei et al. Combination of chemical etching and electrophoretic deposition for the fabrication of multi-scale superhydrophobic Al films
MXPA05008245A (es) Productos de pano limpiador de papel tratados con una composicion de polisiloxano.
CN209507227U (zh) 一种拉伸膜张力控制装置
Khan et al. The influence of additives on the spreading coefficient and adhesion of a film coating formulation to a model tablet surface
EP3297498A1 (en) Hanger and method
Muzzio et al. Tailored polyelectrolyte thin film multilayers to modulate cell adhesion
FI952516A0 (fi) Menetelmä paperin päällystämiseksi ja menetelmällä valmistettu tuote
Saiano et al. Evaluation of mucoadhesive properties of α, β-poly (N-hydroxyethyl)-dl-aspartamide and α, β-poly (aspartylhydrazide) using ATR–FTIR spectroscopy
Emundts et al. Experimental absolute step and kink formation energies on Pb (111) vicinal surfaces
Wokovich et al. Evaluation of substrates for 90° peel adhesion—A collaborative study. I. Medical tapes
CN104861808B (zh) 一种防滑耐磨喷墨打印涂层涂料
König et al. Stress fluctuations in drying polymer dispersions
Kassuga et al. The effect of shear and confinement on the buckling of particle-laden interfaces

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees