TWI246424B - Use of 2-imidazolyl-substituted carbinols for the production of a medicament for the treatment or prophylaxis of diseases caused by ischemic conditions - Google Patents
Use of 2-imidazolyl-substituted carbinols for the production of a medicament for the treatment or prophylaxis of diseases caused by ischemic conditions Download PDFInfo
- Publication number
- TWI246424B TWI246424B TW089122280A TW89122280A TWI246424B TW I246424 B TWI246424 B TW I246424B TW 089122280 A TW089122280 A TW 089122280A TW 89122280 A TW89122280 A TW 89122280A TW I246424 B TWI246424 B TW I246424B
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- Prior art keywords
- pharmaceutical composition
- treatment
- patent application
- phenyl
- treat
- Prior art date
Links
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- 238000011282 treatment Methods 0.000 title claims description 11
- 239000003814 drug Substances 0.000 title abstract description 7
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 238000011321 prophylaxis Methods 0.000 title abstract description 3
- 201000010099 disease Diseases 0.000 title description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 5
- -1 2-imidazolyl-substituted carbinols Chemical class 0.000 title description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims description 29
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19951701A DE19951701A1 (de) | 1999-10-27 | 1999-10-27 | Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI246424B true TWI246424B (en) | 2006-01-01 |
Family
ID=7927020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW089122280A TWI246424B (en) | 1999-10-27 | 2000-10-24 | Use of 2-imidazolyl-substituted carbinols for the production of a medicament for the treatment or prophylaxis of diseases caused by ischemic conditions |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6291502B1 (https=) |
| EP (1) | EP1227811B1 (https=) |
| JP (1) | JP2003512419A (https=) |
| KR (1) | KR20020060213A (https=) |
| CN (1) | CN1188125C (https=) |
| AR (1) | AR026241A1 (https=) |
| AT (1) | ATE257702T1 (https=) |
| AU (1) | AU778836B2 (https=) |
| BR (1) | BR0015024A (https=) |
| CA (1) | CA2388956A1 (https=) |
| CZ (1) | CZ295925B6 (https=) |
| DE (2) | DE19951701A1 (https=) |
| DK (1) | DK1227811T3 (https=) |
| EE (1) | EE200200218A (https=) |
| ES (1) | ES2213621T3 (https=) |
| HK (1) | HK1048938B (https=) |
| HR (1) | HRP20020362A2 (https=) |
| HU (1) | HUP0203213A3 (https=) |
| IL (1) | IL149208A0 (https=) |
| NO (1) | NO20021909L (https=) |
| NZ (1) | NZ518586A (https=) |
| PL (1) | PL355911A1 (https=) |
| PT (1) | PT1227811E (https=) |
| RU (1) | RU2257205C2 (https=) |
| SK (1) | SK5512002A3 (https=) |
| TR (1) | TR200201140T2 (https=) |
| TW (1) | TWI246424B (https=) |
| WO (1) | WO2001030327A2 (https=) |
| YU (1) | YU20902A (https=) |
| ZA (1) | ZA200203035B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6726829B2 (en) * | 1997-04-08 | 2004-04-27 | Scimed Life Systems, Inc. | Method of manufacturing a stent |
| EP1465863B1 (en) | 2002-01-04 | 2008-07-09 | NeuroSearch A/S | Potassium channel modulators |
| AR049847A1 (es) * | 2004-07-29 | 2006-09-06 | Merck & Co Inc | Inhibidores de los canales de potasio |
| RU2373934C1 (ru) * | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| WO2015175845A1 (en) * | 2014-05-15 | 2015-11-19 | Peloton Therapeutics, Inc. | Benzimidazole derivatives and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793407A (fr) * | 1971-12-28 | 1973-06-28 | Hoechst Ag | Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation |
| BE794940A (fr) * | 1972-02-04 | 1973-08-02 | Gist Brocades Nv | Nouveaux composes anorexigenes |
| US4152441A (en) | 1972-02-04 | 1979-05-01 | Gist-Brocades N.V. | Analgesic imidazolemethanols |
| US5063220A (en) * | 1988-10-21 | 1991-11-05 | Syntex Pharmaceuticals, Ltd. | Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| US6175013B1 (en) * | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
| WO1997049704A1 (en) | 1996-06-27 | 1997-12-31 | Janssen Pharmaceutica N.V. | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines |
-
1999
- 1999-10-27 DE DE19951701A patent/DE19951701A1/de not_active Withdrawn
-
2000
- 2000-10-14 IL IL14920800A patent/IL149208A0/xx unknown
- 2000-10-14 AT AT00972764T patent/ATE257702T1/de not_active IP Right Cessation
- 2000-10-14 YU YU20902A patent/YU20902A/sh unknown
- 2000-10-14 AU AU11382/01A patent/AU778836B2/en not_active Ceased
- 2000-10-14 DK DK00972764T patent/DK1227811T3/da active
- 2000-10-14 EE EEP200200218A patent/EE200200218A/xx unknown
- 2000-10-14 KR KR1020027005275A patent/KR20020060213A/ko not_active Withdrawn
- 2000-10-14 TR TR2002/01140T patent/TR200201140T2/xx unknown
- 2000-10-14 NZ NZ518586A patent/NZ518586A/en unknown
- 2000-10-14 HK HK03101149.5A patent/HK1048938B/zh not_active IP Right Cessation
- 2000-10-14 DE DE50005040T patent/DE50005040D1/de not_active Expired - Lifetime
- 2000-10-14 BR BR0015024-0A patent/BR0015024A/pt not_active IP Right Cessation
- 2000-10-14 CA CA002388956A patent/CA2388956A1/en not_active Abandoned
- 2000-10-14 HR HR20020362A patent/HRP20020362A2/hr not_active Application Discontinuation
- 2000-10-14 PT PT00972764T patent/PT1227811E/pt unknown
- 2000-10-14 JP JP2001532747A patent/JP2003512419A/ja not_active Abandoned
- 2000-10-14 CZ CZ20021452A patent/CZ295925B6/cs not_active IP Right Cessation
- 2000-10-14 WO PCT/EP2000/010126 patent/WO2001030327A2/de not_active Ceased
- 2000-10-14 SK SK551-2002A patent/SK5512002A3/sk unknown
- 2000-10-14 ES ES00972764T patent/ES2213621T3/es not_active Expired - Lifetime
- 2000-10-14 PL PL00355911A patent/PL355911A1/xx not_active IP Right Cessation
- 2000-10-14 RU RU2002113666/15A patent/RU2257205C2/ru not_active IP Right Cessation
- 2000-10-14 CN CNB008128219A patent/CN1188125C/zh not_active Expired - Fee Related
- 2000-10-14 HU HU0203213A patent/HUP0203213A3/hu unknown
- 2000-10-14 EP EP00972764A patent/EP1227811B1/de not_active Expired - Lifetime
- 2000-10-24 TW TW089122280A patent/TWI246424B/zh active
- 2000-10-25 AR ARP000105619A patent/AR026241A1/es unknown
- 2000-10-26 US US09/695,920 patent/US6291502B1/en not_active Expired - Fee Related
-
2002
- 2002-04-17 ZA ZA200203035A patent/ZA200203035B/en unknown
- 2002-04-23 NO NO20021909A patent/NO20021909L/no unknown
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