TWI233361B - Methods of preventing UVB-induced skin damage - Google Patents

Info

Publication number

TWI233361B

TWI233361B TW091107218A TW91107218A TWI233361B TW I233361 B TWI233361 B TW I233361B TW 091107218 A TW091107218 A TW 091107218A TW 91107218 A TW91107218 A TW 91107218A TW I233361 B TWI233361 B TW I233361B

Authority

TW

Taiwan

Prior art keywords

tsp

skin

composition

cells

cell

Prior art date

2001-04-13

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title abstract description 81
• 230000037380 skin damage Effects 0.000 title description 27
• 230000007774 longterm Effects 0.000 claims abstract description 47
• 230000037303 wrinkles Effects 0.000 claims abstract description 41
• 230000033115 angiogenesis Effects 0.000 claims abstract description 38
• 101100208237 Bos taurus THBS2 gene Proteins 0.000 claims description 78
• 239000000203 mixture Substances 0.000 claims description 74
• 150000001875 compounds Chemical class 0.000 claims description 31
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims description 27
• 239000004037 angiogenesis inhibitor Substances 0.000 claims description 27
• 210000004204 blood vessel Anatomy 0.000 claims description 23
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims description 19
• 238000011282 treatment Methods 0.000 claims description 16
• 239000004615 ingredient Substances 0.000 claims description 8
• 239000003112 inhibitor Substances 0.000 claims description 8
• 230000036561 sun exposure Effects 0.000 claims description 7
• 230000002265 prevention Effects 0.000 claims description 6
• 230000000699 topical effect Effects 0.000 claims description 6
• 239000003205 fragrance Substances 0.000 claims description 5
• 230000005764 inhibitory process Effects 0.000 claims description 5
• 239000000516 sunscreening agent Substances 0.000 claims description 5
• 230000003796 beauty Effects 0.000 claims description 4
• 230000000475 sunscreen effect Effects 0.000 claims description 3
• 238000012937 correction Methods 0.000 claims description 2
• 239000002537 cosmetic Substances 0.000 claims description 2
• 229910052790 beryllium Inorganic materials 0.000 claims 3
• ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 claims 3
• 208000001840 Dandruff Diseases 0.000 claims 1
• 230000001153 anti-wrinkle effect Effects 0.000 claims 1
• 210000000601 blood cell Anatomy 0.000 claims 1
• 238000011866 long-term treatment Methods 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 abstract description 14
• 210000004027 cell Anatomy 0.000 description 183
• 108090000623 proteins and genes Proteins 0.000 description 117
• 108090000765 processed proteins & peptides Proteins 0.000 description 86
• 210000003491 skin Anatomy 0.000 description 86
• 230000000694 effects Effects 0.000 description 83
• 101100202924 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) tsp-2 gene Proteins 0.000 description 76
• 239000003795 chemical substances by application Substances 0.000 description 75
• 102000004169 proteins and genes Human genes 0.000 description 62
• 235000018102 proteins Nutrition 0.000 description 61
• 150000007523 nucleic acids Chemical class 0.000 description 60
• 241000699670 Mus sp. Species 0.000 description 55
• 108020004707 nucleic acids Proteins 0.000 description 50
• 102000039446 nucleic acids Human genes 0.000 description 50
• 108020004414 DNA Proteins 0.000 description 45
• 102000004196 processed proteins & peptides Human genes 0.000 description 39
• 230000035772 mutation Effects 0.000 description 36
• 206010040954 Skin wrinkling Diseases 0.000 description 35
• 239000012634 fragment Substances 0.000 description 35
• 239000003814 drug Substances 0.000 description 34
• 230000014509 gene expression Effects 0.000 description 34
• -1 vitamin A Natural products 0.000 description 34
• 241001465754 Metazoa Species 0.000 description 27
• 230000005855 radiation Effects 0.000 description 23
• 230000000692 anti-sense effect Effects 0.000 description 22
• 150000003384 small molecules Chemical class 0.000 description 21
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 20
• 150000001413 amino acids Chemical group 0.000 description 20
• 108020004999 messenger RNA Proteins 0.000 description 19
• 229920001184 polypeptide Polymers 0.000 description 19
• 101150060219 tsp-1 gene Proteins 0.000 description 19
• 239000013598 vector Substances 0.000 description 19
• 230000001105 regulatory effect Effects 0.000 description 18
• 238000004458 analytical method Methods 0.000 description 17
• 210000002706 plastid Anatomy 0.000 description 17
• 238000001727 in vivo Methods 0.000 description 16
• 238000011830 transgenic mouse model Methods 0.000 description 16
• 108091028043 Nucleic acid sequence Proteins 0.000 description 15
• 235000001014 amino acid Nutrition 0.000 description 15
• 230000015572 biosynthetic process Effects 0.000 description 15
• 210000001519 tissue Anatomy 0.000 description 15
• 238000013518 transcription Methods 0.000 description 15
• 230000035897 transcription Effects 0.000 description 15
• 230000002950 deficient Effects 0.000 description 14
• 230000006870 function Effects 0.000 description 14
• 238000001476 gene delivery Methods 0.000 description 14
• 238000004519 manufacturing process Methods 0.000 description 14
• 241000699660 Mus musculus Species 0.000 description 13
• 210000002889 endothelial cell Anatomy 0.000 description 13
• 230000004927 fusion Effects 0.000 description 13
• 108020001507 fusion proteins Proteins 0.000 description 13
• 102000037865 fusion proteins Human genes 0.000 description 13
• 238000012360 testing method Methods 0.000 description 13
• 230000009261 transgenic effect Effects 0.000 description 13
• 241000700605 Viruses Species 0.000 description 12
• 230000035755 proliferation Effects 0.000 description 12
• 239000002253 acid Substances 0.000 description 11
• 229940079593 drug Drugs 0.000 description 11
• 239000007924 injection Substances 0.000 description 11
• 238000002347 injection Methods 0.000 description 11
• 210000002510 keratinocyte Anatomy 0.000 description 11
• 125000003729 nucleotide group Chemical group 0.000 description 11
• 238000001890 transfection Methods 0.000 description 11
• FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 description 10
• 108091034117 Oligonucleotide Proteins 0.000 description 10
• 230000001772 anti-angiogenic effect Effects 0.000 description 10
• 210000004207 dermis Anatomy 0.000 description 10
• 239000003446 ligand Substances 0.000 description 10
• 239000002773 nucleotide Substances 0.000 description 10
• 230000002792 vascular Effects 0.000 description 10
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 9
• 229960005070 ascorbic acid Drugs 0.000 description 9
• 230000027455 binding Effects 0.000 description 9
• 102000005962 receptors Human genes 0.000 description 9
• 108020003175 receptors Proteins 0.000 description 9
• 238000012216 screening Methods 0.000 description 9
• 239000000725 suspension Substances 0.000 description 9
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 8
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 8
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 8
• 239000002870 angiogenesis inducing agent Substances 0.000 description 8
• 210000004369 blood Anatomy 0.000 description 8
• 239000008280 blood Substances 0.000 description 8
• 238000000576 coating method Methods 0.000 description 8
• 230000000295 complement effect Effects 0.000 description 8
• 230000002500 effect on skin Effects 0.000 description 8
• 210000002615 epidermis Anatomy 0.000 description 8
• 210000000981 epithelium Anatomy 0.000 description 8
• 238000006467 substitution reaction Methods 0.000 description 8
• 241000701161 unidentified adenovirus Species 0.000 description 8
• 241001430294 unidentified retrovirus Species 0.000 description 8
• 102000004190 Enzymes Human genes 0.000 description 7
• 108090000790 Enzymes Proteins 0.000 description 7
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
• 102100040445 Keratin, type I cytoskeletal 14 Human genes 0.000 description 7
• 108700008625 Reporter Genes Proteins 0.000 description 7
• 102100036034 Thrombospondin-1 Human genes 0.000 description 7
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 7
• 230000004888 barrier function Effects 0.000 description 7
• 239000011248 coating agent Substances 0.000 description 7
• 239000002299 complementary DNA Substances 0.000 description 7
• 230000006378 damage Effects 0.000 description 7
• 238000005516 engineering process Methods 0.000 description 7
• 229940088598 enzyme Drugs 0.000 description 7
• 239000007788 liquid Substances 0.000 description 7
• 239000000243 solution Substances 0.000 description 7
• 238000003786 synthesis reaction Methods 0.000 description 7
• 101150007130 tsp-2 gene Proteins 0.000 description 7
• 239000013603 viral vector Substances 0.000 description 7
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 6
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
• 102000008186 Collagen Human genes 0.000 description 6
• 108010035532 Collagen Proteins 0.000 description 6
• ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 6
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
• 102000035195 Peptidases Human genes 0.000 description 6
• 108091005804 Peptidases Proteins 0.000 description 6
• 206010051246 Photodermatosis Diseases 0.000 description 6
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 6
• 229920001436 collagen Polymers 0.000 description 6
• 230000001186 cumulative effect Effects 0.000 description 6
• 230000003511 endothelial effect Effects 0.000 description 6
• 210000002919 epithelial cell Anatomy 0.000 description 6
• 238000001415 gene therapy Methods 0.000 description 6
• 239000002245 particle Substances 0.000 description 6
• 230000035515 penetration Effects 0.000 description 6
• 239000008194 pharmaceutical composition Substances 0.000 description 6
• 230000008845 photoaging Effects 0.000 description 6
• 238000002360 preparation method Methods 0.000 description 6
• 230000002062 proliferating effect Effects 0.000 description 6
• 238000010186 staining Methods 0.000 description 6
• 238000002054 transplantation Methods 0.000 description 6
• 229940088594 vitamin Drugs 0.000 description 6
• 229930003231 vitamin Natural products 0.000 description 6
• 235000013343 vitamin Nutrition 0.000 description 6
• 239000011782 vitamin Substances 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• 230000037373 wrinkle formation Effects 0.000 description 6
• 108020004705 Codon Proteins 0.000 description 5
• 230000004568 DNA-binding Effects 0.000 description 5
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
• 108010000684 Matrix Metalloproteinases Proteins 0.000 description 5
• 102000002274 Matrix Metalloproteinases Human genes 0.000 description 5
• 241000699666 Mus <mouse, genus> Species 0.000 description 5
• YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 5
• 108010001267 Protein Subunits Proteins 0.000 description 5
• 102000002067 Protein Subunits Human genes 0.000 description 5
• 206010042496 Sunburn Diseases 0.000 description 5
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 5
• 208000027418 Wounds and injury Diseases 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 5
• 230000002354 daily effect Effects 0.000 description 5
• 239000003937 drug carrier Substances 0.000 description 5
• 235000019441 ethanol Nutrition 0.000 description 5
• 239000000835 fiber Substances 0.000 description 5
• 229940038487 grape extract Drugs 0.000 description 5
• 230000012010 growth Effects 0.000 description 5
• 238000009396 hybridization Methods 0.000 description 5
• 239000003018 immunosuppressive agent Substances 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 230000004048 modification Effects 0.000 description 5
• 238000012986 modification Methods 0.000 description 5
• 229960001679 octinoxate Drugs 0.000 description 5
• 239000000419 plant extract Substances 0.000 description 5
• 230000002035 prolonged effect Effects 0.000 description 5
• 230000001902 propagating effect Effects 0.000 description 5
• 235000019833 protease Nutrition 0.000 description 5
• 230000002829 reductive effect Effects 0.000 description 5
• 229930002330 retinoic acid Natural products 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 241000894007 species Species 0.000 description 5
• 238000007920 subcutaneous administration Methods 0.000 description 5
• 239000003826 tablet Substances 0.000 description 5
• 235000019155 vitamin A Nutrition 0.000 description 5
• 239000011719 vitamin A Substances 0.000 description 5
• 229940045997 vitamin a Drugs 0.000 description 5
• 241000894006 Bacteria Species 0.000 description 4
• 239000005711 Benzoic acid Substances 0.000 description 4
• 108091033380 Coding strand Proteins 0.000 description 4
• CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 4
• CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 4
• ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 description 4
• 101100372758 Danio rerio vegfaa gene Proteins 0.000 description 4
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 4
• 241000282412 Homo Species 0.000 description 4
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
• 239000002211 L-ascorbic acid Substances 0.000 description 4
• 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 4
• 201000004681 Psoriasis Diseases 0.000 description 4
• 241000700159 Rattus Species 0.000 description 4
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 4
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 4
• 101150030763 Vegfa gene Proteins 0.000 description 4
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 4
• 229930003427 Vitamin E Natural products 0.000 description 4
• 230000004913 activation Effects 0.000 description 4
• 239000000556 agonist Substances 0.000 description 4
• 230000001580 bacterial effect Effects 0.000 description 4
• 230000001276 controlling effect Effects 0.000 description 4
• ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 4
• 239000003085 diluting agent Substances 0.000 description 4
• 238000002474 experimental method Methods 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 4
• FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 4
• 239000000499 gel Substances 0.000 description 4
• 210000004247 hand Anatomy 0.000 description 4
• 230000036541 health Effects 0.000 description 4
• 230000028993 immune response Effects 0.000 description 4
• 238000000338 in vitro Methods 0.000 description 4
• 238000003780 insertion Methods 0.000 description 4
• 230000037431 insertion Effects 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 238000001990 intravenous administration Methods 0.000 description 4
• 239000002502 liposome Substances 0.000 description 4
• 239000000463 material Substances 0.000 description 4
• 210000004379 membrane Anatomy 0.000 description 4
• 239000012528 membrane Substances 0.000 description 4
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
• 230000000877 morphologic effect Effects 0.000 description 4
• 238000004806 packaging method and process Methods 0.000 description 4
• 210000002729 polyribosome Anatomy 0.000 description 4
• 238000001556 precipitation Methods 0.000 description 4
• 230000008569 process Effects 0.000 description 4
• 210000004761 scalp Anatomy 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• 238000004611 spectroscopical analysis Methods 0.000 description 4
• 230000001360 synchronised effect Effects 0.000 description 4
• 230000001225 therapeutic effect Effects 0.000 description 4
• 229940098465 tincture Drugs 0.000 description 4
• 239000004408 titanium dioxide Substances 0.000 description 4
• 229960001727 tretinoin Drugs 0.000 description 4
• 230000003612 virological effect Effects 0.000 description 4
• 235000019165 vitamin E Nutrition 0.000 description 4
• 229940046009 vitamin E Drugs 0.000 description 4
• 239000011709 vitamin E Substances 0.000 description 4
• YSAJFXWTVFGPAX-UHFFFAOYSA-N 2-[(2,4-dioxo-1h-pyrimidin-5-yl)oxy]acetic acid Chemical compound OC(=O)COC1=CNC(=O)NC1=O YSAJFXWTVFGPAX-UHFFFAOYSA-N 0.000 description 3
• WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 3
• ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 3
• 239000013607 AAV vector Substances 0.000 description 3
• XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 description 3
• AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 description 3
• ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 description 3
• AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 description 3
• KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 description 3
• 241000702421 Dependoparvovirus Species 0.000 description 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
• 108060003951 Immunoglobulin Proteins 0.000 description 3
• 235000000069 L-ascorbic acid Nutrition 0.000 description 3
• 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 3
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 3
• 235000019687 Lamb Nutrition 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 3
• 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 description 3
• 102000018697 Membrane Proteins Human genes 0.000 description 3
• 108010052285 Membrane Proteins Proteins 0.000 description 3
• 206010028980 Neoplasm Diseases 0.000 description 3
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 210000001744 T-lymphocyte Anatomy 0.000 description 3
• 108091008605 VEGF receptors Proteins 0.000 description 3
• 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 description 3
• 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 3
• 108700005077 Viral Genes Proteins 0.000 description 3
• 206010052428 Wound Diseases 0.000 description 3
• 235000014104 aloe vera supplement Nutrition 0.000 description 3
• 229960004050 aminobenzoic acid Drugs 0.000 description 3
• 239000003242 anti bacterial agent Substances 0.000 description 3
• 230000003527 anti-angiogenesis Effects 0.000 description 3
• 239000002585 base Substances 0.000 description 3
• 235000010233 benzoic acid Nutrition 0.000 description 3
• 229920000249 biocompatible polymer Polymers 0.000 description 3
• 230000004071 biological effect Effects 0.000 description 3
• 230000033228 biological regulation Effects 0.000 description 3
• 230000005540 biological transmission Effects 0.000 description 3
• 239000000969 carrier Substances 0.000 description 3
• 230000015556 catabolic process Effects 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000012790 confirmation Methods 0.000 description 3
• 238000013270 controlled release Methods 0.000 description 3
• 239000008406 cosmetic ingredient Substances 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 238000006731 degradation reaction Methods 0.000 description 3
• 238000012217 deletion Methods 0.000 description 3
• 230000037430 deletion Effects 0.000 description 3
• 230000001419 dependent effect Effects 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 230000009977 dual effect Effects 0.000 description 3
• 238000001962 electrophoresis Methods 0.000 description 3
• 210000003038 endothelium Anatomy 0.000 description 3
• 210000001339 epidermal cell Anatomy 0.000 description 3
• 210000005175 epidermal keratinocyte Anatomy 0.000 description 3
• 239000013604 expression vector Substances 0.000 description 3
• 210000002950 fibroblast Anatomy 0.000 description 3
• 229960004881 homosalate Drugs 0.000 description 3
• 210000000987 immune system Anatomy 0.000 description 3
• 238000003125 immunofluorescent labeling Methods 0.000 description 3
• 102000018358 immunoglobulin Human genes 0.000 description 3
• 229940124589 immunosuppressive drug Drugs 0.000 description 3
• 208000015181 infectious disease Diseases 0.000 description 3
• 210000004969 inflammatory cell Anatomy 0.000 description 3
• 230000007246 mechanism Effects 0.000 description 3
• 239000002609 medium Substances 0.000 description 3
• 230000014399 negative regulation of angiogenesis Effects 0.000 description 3
• 230000002018 overexpression Effects 0.000 description 3
• 239000012188 paraffin wax Substances 0.000 description 3
• 238000002823 phage display Methods 0.000 description 3
• 239000008177 pharmaceutical agent Substances 0.000 description 3
• 230000008832 photodamage Effects 0.000 description 3
• 230000003389 potentiating effect Effects 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• 230000001177 retroviral effect Effects 0.000 description 3
• 239000000523 sample Substances 0.000 description 3
• 208000024891 symptom Diseases 0.000 description 3
• 230000002103 transcriptional effect Effects 0.000 description 3
• 108091006107 transcriptional repressors Proteins 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 230000002485 urinary effect Effects 0.000 description 3
• PBTPTBMYJPCXRQ-MGMRMFRLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;hexadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCC(O)=O PBTPTBMYJPCXRQ-MGMRMFRLSA-N 0.000 description 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
• QAQJMLQRFWZOBN-UHFFFAOYSA-N 2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-UHFFFAOYSA-N 0.000 description 2
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
• OVONXEQGWXGFJD-UHFFFAOYSA-N 4-sulfanylidene-1h-pyrimidin-2-one Chemical compound SC=1C=CNC(=O)N=1 OVONXEQGWXGFJD-UHFFFAOYSA-N 0.000 description 2
• OIVLITBTBDPEFK-UHFFFAOYSA-N 5,6-dihydrouracil Chemical compound O=C1CCNC(=O)N1 OIVLITBTBDPEFK-UHFFFAOYSA-N 0.000 description 2
• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
• 235000017491 Bambusa tulda Nutrition 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 108010078791 Carrier Proteins Proteins 0.000 description 2
• DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 description 2
• QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 2
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 2
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
• WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 2
• 102000052510 DNA-Binding Proteins Human genes 0.000 description 2
• 101710096438 DNA-binding protein Proteins 0.000 description 2
• 201000004624 Dermatitis Diseases 0.000 description 2
• 206010015150 Erythema Diseases 0.000 description 2
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
• 108010028690 Fish Proteins Proteins 0.000 description 2
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• 102000000589 Interleukin-1 Human genes 0.000 description 2
• 108010002352 Interleukin-1 Proteins 0.000 description 2
• 101150034617 K14 gene Proteins 0.000 description 2
• WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
• WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 2
• 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 description 2
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
• 108060001084 Luciferase Proteins 0.000 description 2
• 239000005089 Luciferase Substances 0.000 description 2
• 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 2
• 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 2
• 102100025169 Max-binding protein MNT Human genes 0.000 description 2
• 108700021154 Metallothionein 3 Proteins 0.000 description 2
• 102100028708 Metallothionein-3 Human genes 0.000 description 2
• HYVABZIGRDEKCD-UHFFFAOYSA-N N(6)-dimethylallyladenine Chemical compound CC(C)=CCNC1=NC=NC2=C1N=CN2 HYVABZIGRDEKCD-UHFFFAOYSA-N 0.000 description 2
• 108700020796 Oncogene Proteins 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 102000007079 Peptide Fragments Human genes 0.000 description 2
• 108010033276 Peptide Fragments Proteins 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 244000082204 Phyllostachys viridis Species 0.000 description 2
• 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
• 108010006785 Taq Polymerase Proteins 0.000 description 2
• 102100029529 Thrombospondin-2 Human genes 0.000 description 2
• 101710154778 Thymidylate synthase 1 Proteins 0.000 description 2
• 239000007983 Tris buffer Substances 0.000 description 2
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
• 229930003268 Vitamin C Natural products 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 238000009825 accumulation Methods 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 230000032683 aging Effects 0.000 description 2
• 238000012867 alanine scanning Methods 0.000 description 2
• 229940069521 aloe extract Drugs 0.000 description 2
• 150000001412 amines Chemical class 0.000 description 2
• 230000002491 angiogenic effect Effects 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• 230000006907 apoptotic process Effects 0.000 description 2
• 239000011425 bamboo Substances 0.000 description 2
• 230000037429 base substitution Effects 0.000 description 2
• RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 2
• 239000012965 benzophenone Substances 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 238000002659 cell therapy Methods 0.000 description 2
• 239000003153 chemical reaction reagent Substances 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 230000001684 chronic effect Effects 0.000 description 2
• 239000000084 colloidal system Substances 0.000 description 2
• 210000000805 cytoplasm Anatomy 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 230000029087 digestion Effects 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• 201000010099 disease Diseases 0.000 description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
• 210000005069 ears Anatomy 0.000 description 2
• 210000004177 elastic tissue Anatomy 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 239000003623 enhancer Substances 0.000 description 2
• 231100000321 erythema Toxicity 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 210000002744 extracellular matrix Anatomy 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 235000019253 formic acid Nutrition 0.000 description 2
• 239000007789 gas Substances 0.000 description 2
• 238000010353 genetic engineering Methods 0.000 description 2
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
• 230000003779 hair growth Effects 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 238000010191 image analysis Methods 0.000 description 2
• 238000012744 immunostaining Methods 0.000 description 2
• 229940125721 immunosuppressive agent Drugs 0.000 description 2
• 208000014674 injury Diseases 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 230000001678 irradiating effect Effects 0.000 description 2
• 238000011813 knockout mouse model Methods 0.000 description 2
• 239000010410 layer Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 210000004779 membrane envelope Anatomy 0.000 description 2
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
• 238000000520 microinjection Methods 0.000 description 2
• 210000004925 microvascular endothelial cell Anatomy 0.000 description 2
• 238000002703 mutagenesis Methods 0.000 description 2
• 231100000350 mutagenesis Toxicity 0.000 description 2
• 210000000440 neutrophil Anatomy 0.000 description 2
• 229950000516 padimate Drugs 0.000 description 2
• LXTZRIBXKVRLOA-UHFFFAOYSA-N padimate a Chemical compound CCCCCOC(=O)C1=CC=C(N(C)C)C=C1 LXTZRIBXKVRLOA-UHFFFAOYSA-N 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 230000000149 penetrating effect Effects 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• 239000002953 phosphate buffered saline Substances 0.000 description 2
• 230000002797 proteolythic effect Effects 0.000 description 2
• 230000009467 reduction Effects 0.000 description 2
• 102000037983 regulatory factors Human genes 0.000 description 2
• 108091008025 regulatory factors Proteins 0.000 description 2
• 230000008521 reorganization Effects 0.000 description 2
• 230000001850 reproductive effect Effects 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 238000007665 sagging Methods 0.000 description 2
• 210000001732 sebaceous gland Anatomy 0.000 description 2
• 210000004927 skin cell Anatomy 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 239000002689 soil Substances 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 238000010254 subcutaneous injection Methods 0.000 description 2
• 239000007929 subcutaneous injection Substances 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 229910052717 sulfur Inorganic materials 0.000 description 2
• MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• 108010060887 thrombospondin 2 Proteins 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• 229940042585 tocopherol acetate Drugs 0.000 description 2
• 108091006106 transcriptional activators Proteins 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
• DZGWFCGJZKJUFP-UHFFFAOYSA-N tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 description 2
• 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 2
• 229940035893 uracil Drugs 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• 210000002845 virion Anatomy 0.000 description 2
• 235000019154 vitamin C Nutrition 0.000 description 2
• 239000011718 vitamin C Substances 0.000 description 2
• 230000003442 weekly effect Effects 0.000 description 2
• 230000029663 wound healing Effects 0.000 description 2
• AEELXMHQIJJMKP-QWWZWVQMSA-N (2r,3r)-3-sulfanylbutane-1,2,4-triol Chemical compound OC[C@@H](O)[C@H](S)CO AEELXMHQIJJMKP-QWWZWVQMSA-N 0.000 description 1
• SMWADGDVGCZIGK-AXDSSHIGSA-N (2s)-5-phenylpyrrolidine-2-carboxylic acid Chemical compound N1[C@H](C(=O)O)CCC1C1=CC=CC=C1 SMWADGDVGCZIGK-AXDSSHIGSA-N 0.000 description 1
• AGTSSZRZBSNTGQ-ITZCFHCWSA-N (2s,3r)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomet Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 AGTSSZRZBSNTGQ-ITZCFHCWSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical compound C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
• HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
• XMSMHKMPBNTBOD-UHFFFAOYSA-N 2-dimethylamino-6-hydroxypurine Chemical compound N1C(N(C)C)=NC(=O)C2=C1N=CN2 XMSMHKMPBNTBOD-UHFFFAOYSA-N 0.000 description 1
• UDFCPINYCXWKOQ-UHFFFAOYSA-N 2-methyl-7H-purin-6-amine Chemical compound CC1=NC(=C2NC=NC2=N1)N.NC1=C2NC=NC2=NC(=N1)C UDFCPINYCXWKOQ-UHFFFAOYSA-N 0.000 description 1
• AXDJCCTWPBKUKL-UHFFFAOYSA-N 4-[(4-aminophenyl)-(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]aniline;hydron;chloride Chemical compound Cl.C1=CC(=N)C(C)=CC1=C(C=1C=CC(N)=CC=1)C1=CC=C(N)C=C1 AXDJCCTWPBKUKL-UHFFFAOYSA-N 0.000 description 1
• GJAKJCICANKRFD-UHFFFAOYSA-N 4-acetyl-4-amino-1,3-dihydropyrimidin-2-one Chemical compound CC(=O)C1(N)NC(=O)NC=C1 GJAKJCICANKRFD-UHFFFAOYSA-N 0.000 description 1
• MQJSSLBGAQJNER-UHFFFAOYSA-N 5-(methylaminomethyl)-1h-pyrimidine-2,4-dione Chemical compound CNCC1=CNC(=O)NC1=O MQJSSLBGAQJNER-UHFFFAOYSA-N 0.000 description 1
• LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 description 1
• VNQVEQVUZZSBTJ-UHFFFAOYSA-N 5-methyl-2-sulfanylidene-1H-pyrimidin-4-one Chemical compound CC1=CNC(=S)NC1=O.CC1=CNC(=S)NC1=O VNQVEQVUZZSBTJ-UHFFFAOYSA-N 0.000 description 1
• ZLAQATDNGLKIEV-UHFFFAOYSA-N 5-methyl-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound CC1=CNC(=S)NC1=O ZLAQATDNGLKIEV-UHFFFAOYSA-N 0.000 description 1
• DCPSTSVLRXOYGS-UHFFFAOYSA-N 6-amino-1h-pyrimidine-2-thione Chemical compound NC1=CC=NC(S)=N1 DCPSTSVLRXOYGS-UHFFFAOYSA-N 0.000 description 1
• 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
• MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 201000004384 Alopecia Diseases 0.000 description 1
• USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
• 239000005695 Ammonium acetate Substances 0.000 description 1
• 102000008076 Angiogenic Proteins Human genes 0.000 description 1
• 108010074415 Angiogenic Proteins Proteins 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 108010011485 Aspartame Proteins 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• PJLLLFGQPSJEMQ-UHFFFAOYSA-N CC1(NC(C2=NC=NC2=N1)=O)N.CC1(NC(C2=NC=NC2=N1)=O)N Chemical compound CC1(NC(C2=NC=NC2=N1)=O)N.CC1(NC(C2=NC=NC2=N1)=O)N PJLLLFGQPSJEMQ-UHFFFAOYSA-N 0.000 description 1
• 102000053028 CD36 Antigens Human genes 0.000 description 1
• 108010045374 CD36 Antigens Proteins 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 208000005623 Carcinogenesis Diseases 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 102000053642 Catalytic RNA Human genes 0.000 description 1
• 108090000994 Catalytic RNA Proteins 0.000 description 1
• 208000002177 Cataract Diseases 0.000 description 1
• 241000258920 Chilopoda Species 0.000 description 1
• 241001503987 Clematis vitalba Species 0.000 description 1
• 108020004635 Complementary DNA Proteins 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 108091007045 Cullin Ring E3 Ligases Proteins 0.000 description 1
• 229930105110 Cyclosporin A Natural products 0.000 description 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 description 1
• ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 description 1
• ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 description 1
• HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 description 1
• KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
• COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 230000009946 DNA mutation Effects 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• 230000006820 DNA synthesis Effects 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 102000016942 Elastin Human genes 0.000 description 1
• 108010014258 Elastin Proteins 0.000 description 1
• 102100021309 Elongation factor Ts, mitochondrial Human genes 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 102100031780 Endonuclease Human genes 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 108010067770 Endopeptidase K Proteins 0.000 description 1
• 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
• 206010014970 Ephelides Diseases 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 108091029865 Exogenous DNA Proteins 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
• 241000724791 Filamentous phage Species 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• PNKUSGQVOMIXLU-UHFFFAOYSA-N Formamidine Chemical compound NC=N PNKUSGQVOMIXLU-UHFFFAOYSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 208000003098 Ganglion Cysts Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 102000013382 Gelatinases Human genes 0.000 description 1
• 108010026132 Gelatinases Proteins 0.000 description 1
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
• 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
• 229920001503 Glucan Polymers 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 108010068370 Glutens Proteins 0.000 description 1
• 208000009889 Herpes Simplex Diseases 0.000 description 1
• 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
• 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 1
• 101000895350 Homo sapiens Elongation factor Ts, mitochondrial Proteins 0.000 description 1
• 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 description 1
• 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 description 1
• 206010020400 Hostility Diseases 0.000 description 1
• 102000002265 Human Growth Hormone Human genes 0.000 description 1
• 108010000521 Human Growth Hormone Proteins 0.000 description 1
• 239000000854 Human Growth Hormone Substances 0.000 description 1
• 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
• 108010003272 Hyaluronate lyase Proteins 0.000 description 1
• 102000001974 Hyaluronidases Human genes 0.000 description 1
• 206010020880 Hypertrophy Diseases 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000012214 Immunoproteins Human genes 0.000 description 1
• 108010036650 Immunoproteins Proteins 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 229930010555 Inosine Natural products 0.000 description 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 108010066321 Keratin-14 Proteins 0.000 description 1
• 102000011782 Keratins Human genes 0.000 description 1
• 108010076876 Keratins Proteins 0.000 description 1
• 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
• QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
• 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 229920000057 Mannan Polymers 0.000 description 1
• 208000003351 Melanosis Diseases 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• 235000006679 Mentha X verticillata Nutrition 0.000 description 1
• 235000002899 Mentha suaveolens Nutrition 0.000 description 1
• 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 101100518501 Mus musculus Spp1 gene Proteins 0.000 description 1
• 241000588653 Neisseria Species 0.000 description 1
• 206010029113 Neovascularisation Diseases 0.000 description 1
• 102000019040 Nuclear Antigens Human genes 0.000 description 1
• 108010051791 Nuclear Antigens Proteins 0.000 description 1
• 108010079246 OMPA outer membrane proteins Proteins 0.000 description 1
• 102000043276 Oncogene Human genes 0.000 description 1
• 108010093625 Opioid Peptides Proteins 0.000 description 1
• 102000001490 Opioid Peptides Human genes 0.000 description 1
• 101710116435 Outer membrane protein Proteins 0.000 description 1
• 101710160107 Outer membrane protein A Proteins 0.000 description 1
• 108010067372 Pancreatic elastase Proteins 0.000 description 1
• 102000016387 Pancreatic elastase Human genes 0.000 description 1
• 229930040373 Paraformaldehyde Natural products 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 206010057249 Phagocytosis Diseases 0.000 description 1
• 208000012641 Pigmentation disease Diseases 0.000 description 1
• 229910052778 Plutonium Inorganic materials 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
• 241000382353 Pupa Species 0.000 description 1
• 108020004518 RNA Probes Proteins 0.000 description 1
• 239000003391 RNA probe Substances 0.000 description 1
• 101000808006 Rattus norvegicus Vascular endothelial growth factor A Proteins 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 108700025701 Retinoblastoma Genes Proteins 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 235000004443 Ricinus communis Nutrition 0.000 description 1
• 101800001440 Rimorphin Proteins 0.000 description 1
• 102400000235 Rimorphin Human genes 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 102000003800 Selectins Human genes 0.000 description 1
• 108090000184 Selectins Proteins 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 108090000899 Serralysin Proteins 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 206010040829 Skin discolouration Diseases 0.000 description 1
• 206010040914 Skin reaction Diseases 0.000 description 1
• 206010072170 Skin wound Diseases 0.000 description 1
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
• 206010064127 Solar lentigo Diseases 0.000 description 1
• 241000519995 Stachys sylvatica Species 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 208000005400 Synovial Cyst Diseases 0.000 description 1
• 108700005078 Synthetic Genes Proteins 0.000 description 1
• 101150052863 THY1 gene Proteins 0.000 description 1
• 108091036066 Three prime untranslated region Proteins 0.000 description 1
• 102000002938 Thrombospondin Human genes 0.000 description 1
• 108060008245 Thrombospondin Proteins 0.000 description 1
• 108010046722 Thrombospondin 1 Proteins 0.000 description 1
• 102400001320 Transforming growth factor alpha Human genes 0.000 description 1
• 101800004564 Transforming growth factor alpha Proteins 0.000 description 1
• 108700019146 Transgenes Proteins 0.000 description 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
• 239000013504 Triton X-100 Substances 0.000 description 1
• 229920004890 Triton X-100 Polymers 0.000 description 1
• 108090000631 Trypsin Proteins 0.000 description 1
• 102000004142 Trypsin Human genes 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 102000009270 Tumour necrosis factor alpha Human genes 0.000 description 1
• 108050000101 Tumour necrosis factor alpha Proteins 0.000 description 1
• LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
• TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 102100039037 Vascular endothelial growth factor A Human genes 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 230000009418 agronomic effect Effects 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 239000003513 alkali Substances 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 235000019257 ammonium acetate Nutrition 0.000 description 1
• 229940043376 ammonium acetate Drugs 0.000 description 1
• 210000003484 anatomy Anatomy 0.000 description 1
• RANHLFAPKWTQOO-UHFFFAOYSA-N aniline;propane Chemical compound CCC.NC1=CC=CC=C1 RANHLFAPKWTQOO-UHFFFAOYSA-N 0.000 description 1
• 230000008485 antagonism Effects 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• 230000000781 anti-lymphocytic effect Effects 0.000 description 1
• 230000001857 anti-mycotic effect Effects 0.000 description 1
• 230000002137 anti-vascular effect Effects 0.000 description 1
• 230000000840 anti-viral effect Effects 0.000 description 1
• 239000000427 antigen Substances 0.000 description 1
• 108091007433 antigens Proteins 0.000 description 1
• 102000036639 antigens Human genes 0.000 description 1
• 239000002543 antimycotic Substances 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000000074 antisense oligonucleotide Substances 0.000 description 1
• 238000012230 antisense oligonucleotides Methods 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 238000003491 array Methods 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
• 230000011681 asexual reproduction Effects 0.000 description 1
• 238000013465 asexual reproduction Methods 0.000 description 1
• 239000000605 aspartame Substances 0.000 description 1
• IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
• 235000010357 aspartame Nutrition 0.000 description 1
• 229960003438 aspartame Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 230000003385 bacteriostatic effect Effects 0.000 description 1
• 210000002469 basement membrane Anatomy 0.000 description 1
• 229940049706 benzodiazepine Drugs 0.000 description 1
• 229960004365 benzoic acid Drugs 0.000 description 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 239000003833 bile salt Substances 0.000 description 1
• 229940093761 bile salts Drugs 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 239000007853 buffer solution Substances 0.000 description 1
• 238000010804 cDNA synthesis Methods 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 235000011148 calcium chloride Nutrition 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 230000036952 cancer formation Effects 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 230000006315 carbonylation Effects 0.000 description 1
• 238000005810 carbonylation reaction Methods 0.000 description 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 210000001054 cardiac fibroblast Anatomy 0.000 description 1
• 238000012219 cassette mutagenesis Methods 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 230000004709 cell invasion Effects 0.000 description 1
• 239000013592 cell lysate Substances 0.000 description 1
• 239000002771 cell marker Substances 0.000 description 1
• 239000006285 cell suspension Substances 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• 210000004081 cilia Anatomy 0.000 description 1
• 229940021231 clearskin Drugs 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 230000002301 combined effect Effects 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 239000000562 conjugate Substances 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 230000030944 contact inhibition Effects 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 230000002596 correlated effect Effects 0.000 description 1
• 230000000875 corresponding effect Effects 0.000 description 1
• 208000018999 crinkle Diseases 0.000 description 1
• 230000004734 cutaneous carcinogenesis Effects 0.000 description 1
• 201000010251 cutis laxa Diseases 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
• SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
• HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 238000002845 discoloration Methods 0.000 description 1
• 108010007093 dispase Proteins 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 230000001516 effect on protein Effects 0.000 description 1
• 229920002549 elastin Polymers 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 230000002121 endocytic effect Effects 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 230000006862 enzymatic digestion Effects 0.000 description 1
• 238000001976 enzyme digestion Methods 0.000 description 1
• 230000036566 epidermal hyperplasia Effects 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 210000003414 extremity Anatomy 0.000 description 1
• 210000000744 eyelid Anatomy 0.000 description 1
• 230000001815 facial effect Effects 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 210000003495 flagella Anatomy 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
• 229960002949 fluorouracil Drugs 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 238000012248 genetic selection Methods 0.000 description 1
• 210000004602 germ cell Anatomy 0.000 description 1
• 210000004907 gland Anatomy 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 239000003292 glue Substances 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 235000021312 gluten Nutrition 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 239000002515 guano Substances 0.000 description 1
• 208000024963 hair loss Diseases 0.000 description 1
• 230000003676 hair loss Effects 0.000 description 1
• 229910001385 heavy metal Inorganic materials 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 238000002744 homologous recombination Methods 0.000 description 1
• 230000006801 homologous recombination Effects 0.000 description 1
• 230000003054 hormonal effect Effects 0.000 description 1
• 102000057063 human MAPT Human genes 0.000 description 1
• 102000058223 human VEGFA Human genes 0.000 description 1
• 229960002773 hyaluronidase Drugs 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 238000007654 immersion Methods 0.000 description 1
• 238000010166 immunofluorescence Methods 0.000 description 1
• 238000011532 immunohistochemical staining Methods 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000003999 initiator Substances 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 229960003786 inosine Drugs 0.000 description 1
• 239000012212 insulator Substances 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 230000004807 localization Effects 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 210000002751 lymph Anatomy 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
• 229960001252 methamphetamine Drugs 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
• 230000000813 microbial effect Effects 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 239000003094 microcapsule Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 239000011859 microparticle Substances 0.000 description 1
• 210000004088 microvessel Anatomy 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 239000003226 mitogen Substances 0.000 description 1
• 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
• 239000002324 mouth wash Substances 0.000 description 1
• 229940051866 mouthwash Drugs 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 210000000663 muscle cell Anatomy 0.000 description 1
• XJVXMWNLQRTRGH-UHFFFAOYSA-N n-(3-methylbut-3-enyl)-2-methylsulfanyl-7h-purin-6-amine Chemical compound CSC1=NC(NCCC(C)=C)=C2NC=NC2=N1 XJVXMWNLQRTRGH-UHFFFAOYSA-N 0.000 description 1
• 210000004897 n-terminal region Anatomy 0.000 description 1
• 229940097496 nasal spray Drugs 0.000 description 1
• 239000007922 nasal spray Substances 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 210000003061 neural cell Anatomy 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 210000002445 nipple Anatomy 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 239000000346 nonvolatile oil Substances 0.000 description 1
• 230000037311 normal skin Effects 0.000 description 1
• 239000002777 nucleoside Substances 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 210000002747 omentum Anatomy 0.000 description 1
• 239000003399 opiate peptide Substances 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 210000002220 organoid Anatomy 0.000 description 1
• DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
• 229960001173 oxybenzone Drugs 0.000 description 1
• 206010033675 panniculitis Diseases 0.000 description 1
• 238000004091 panning Methods 0.000 description 1
• 229920002866 paraformaldehyde Polymers 0.000 description 1
• 239000006072 paste Substances 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• LQRJAEQXMSMEDP-XCHBZYMASA-N peptide a Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C/C=1C=CC=CC=1)C(N)=O)C(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C\C1=CC=CC=C1 LQRJAEQXMSMEDP-XCHBZYMASA-N 0.000 description 1
• RJSZPKZQGIKVAU-UXBJKDEOSA-N peptide f Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C(C)C)C(C)C)C1=CC=CC=C1 RJSZPKZQGIKVAU-UXBJKDEOSA-N 0.000 description 1
• 230000035699 permeability Effects 0.000 description 1
• 230000008782 phagocytosis Effects 0.000 description 1
• 239000002831 pharmacologic agent Substances 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
• 239000002644 phorbol ester Substances 0.000 description 1
• 239000008363 phosphate buffer Substances 0.000 description 1
• 150000003016 phosphoric acids Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 230000019612 pigmentation Effects 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• OYEHPCDNVJXUIW-UHFFFAOYSA-N plutonium atom Chemical compound [Pu] OYEHPCDNVJXUIW-UHFFFAOYSA-N 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 239000008389 polyethoxylated castor oil Substances 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 239000004633 polyglycolic acid Substances 0.000 description 1
• 239000004626 polylactic acid Substances 0.000 description 1
• 238000003752 polymerase chain reaction Methods 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 150000004804 polysaccharides Chemical class 0.000 description 1
• 229920001296 polysiloxane Polymers 0.000 description 1
• 230000001124 posttranscriptional effect Effects 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000002028 premature Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 230000000644 propagated effect Effects 0.000 description 1
• 235000019419 proteases Nutrition 0.000 description 1
• 239000003531 protein hydrolysate Substances 0.000 description 1
• 230000004850 protein–protein interaction Effects 0.000 description 1
• 210000001938 protoplast Anatomy 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 230000007420 reactivation Effects 0.000 description 1
• 230000006884 regulation of angiogenesis Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 230000033458 reproduction Effects 0.000 description 1
• 210000005132 reproductive cell Anatomy 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
• 229960001755 resorcinol Drugs 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• 230000002207 retinal effect Effects 0.000 description 1
• 229960003471 retinol Drugs 0.000 description 1
• 235000020944 retinol Nutrition 0.000 description 1
• 239000011607 retinol Substances 0.000 description 1
• 150000003290 ribose derivatives Chemical class 0.000 description 1
• 108091092562 ribozyme Proteins 0.000 description 1
• 235000019204 saccharin Nutrition 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 229940081974 saccharin Drugs 0.000 description 1
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 239000012723 sample buffer Substances 0.000 description 1
• 239000004576 sand Substances 0.000 description 1
• 102000014452 scavenger receptors Human genes 0.000 description 1
• 108010078070 scavenger receptors Proteins 0.000 description 1
• 238000012106 screening analysis Methods 0.000 description 1
• 230000037307 sensitive skin Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 230000008054 signal transmission Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 235000012239 silicon dioxide Nutrition 0.000 description 1
• 230000009759 skin aging Effects 0.000 description 1
• 230000037370 skin discoloration Effects 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 230000037394 skin elasticity Effects 0.000 description 1
• 230000035483 skin reaction Effects 0.000 description 1
• 231100000430 skin reaction Toxicity 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 210000001082 somatic cell Anatomy 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 150000005846 sugar alcohols Polymers 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 239000011593 sulfur Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 239000002344 surface layer Substances 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 238000004114 suspension culture Methods 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 230000002194 synthesizing effect Effects 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
• 210000003813 thumb Anatomy 0.000 description 1
• 230000036962 time dependent Effects 0.000 description 1
• 239000003104 tissue culture media Substances 0.000 description 1
• 230000017423 tissue regeneration Effects 0.000 description 1
• 229960005196 titanium dioxide Drugs 0.000 description 1
• WYKQDEPZMVTTSJ-UHFFFAOYSA-J titanium(4+);tetrabenzoate Chemical compound [Ti+4].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 WYKQDEPZMVTTSJ-UHFFFAOYSA-J 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• 239000013638 trimer Substances 0.000 description 1
• GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
• 239000012588 trypsin Substances 0.000 description 1
• 230000005747 tumor angiogenesis Effects 0.000 description 1
• 230000004614 tumor growth Effects 0.000 description 1
• 238000010396 two-hybrid screening Methods 0.000 description 1
• 229960003732 tyramine Drugs 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• 238000012762 unpaired Student’s t-test Methods 0.000 description 1
• 229940116269 uric acid Drugs 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 238000001291 vacuum drying Methods 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 230000006426 vascular sprouting Effects 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 235000021419 vinegar Nutrition 0.000 description 1
• 230000001018 virulence Effects 0.000 description 1
• 230000009278 visceral effect Effects 0.000 description 1
• 239000008215 water for injection Substances 0.000 description 1
• WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
• 229940075420 xanthine Drugs 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• 238000007805 zymography Methods 0.000 description 1